Hakkeem, Jafrina Jasmin Binti Abdul (2019) The correlation between the vitamin D level in serum and the percentage of Basophil in children with atopic dermatitis in Saiful Anwar Hospital. Sarjana thesis, Universitas Brawijaya.
Abstract
Vitamin D memiliki kemampuan untuk menekan peradangan dan properti imunomodulatornya memungkinkan ia untuk digunakan sebagai pengobatan untuk dermatitis atopik. Pasien dengan Dermatitis Atopik memiliki jumlah Basofil yang tinggi di dalam lesi kulit mereka. Tujuan dari penelitian ini adalah untuk mengetahui hubungan antara kadar Vitamin D dan persentase Basofil pada anak-anak dengan Dermatitis Atopik di Rumah Sakit Saiful Anwar. Desain penelitian ini adalah analitik observasional dengan pendekatan cross-sectional. Pengukuran kadar Vitamin D pada pasien dilakukan dengan menggunakan metode Enzyme-linked Immunosorbent Assays (ELISA). Nilainya diukur dalam nmol / L. Sementara itu, Basofil diukur dengan Hematology Analyzer menggunakan sampel darah pasien. Ada 12 pasien dalam penelitian ini, lima laki-laki dan tujuh perempuan, berusia 6,33 ± 2,96 bulan. Ada tujuh pasien dengan defisiensi vitamin D (25 (OH) D <20 ng / ml). Tiga pasien memiliki kekurangan vitamin D (25 (OH) D 20-30 ng / ml) dan hanya dua pasien yang memiliki jumlah vitamin D (25 (OH) D> 30 ng / ml) yang cukup. Hubungan antara kadar Vitamin D dan jumlah Basophil dianalisis menggunakan uji Anova satu arah dan korelasi Pearson. Korelasi negatif yang signifikan terdeteksi antara kadar Vitamin D dan jumlah Basofil (p = 0,029, r = -0,626). Kesimpulannya, terdapat korelasi antara kadar vitamin D dan jumlah Basofil pada pasien dengan Dermatitis Atopik. Dimana semakin rendah kadar Vitamin D, semakin tinggi jumlah Basophil.
English Abstract
Vitamin D has the ability to repress inflammation and its immunomodulatory property allows it to be used as a treatment for Atopic Dermatitis. Patients with Atopic Dermatitis have high amounts of Basophils in their skin lesions. The aim of this study was to determine the correlation between the level of Vitamin D and the percentage of Basophils in children with Atopic Dermatitis in Saiful Anwar Hospital. In this crss-sectional study, the measurement of Vitamin D level in patients was conducted using the Enzyme-linked Immunosorbent Assays (ELISA) method. The values were measured in nmol/L. Meanwhile, Basophils were measured using a Hematolgy Analyzer. There were 12 patients in this study, five males and seven females, aged 6.33 ± 2.96 months. There were seven patients with Vitamin D deficiency (25 (OH) D < 20 ng/mL). Three patients had Vitamin D insufficiency (25 (OH) D 20-30 ng/mL) and only two patients had sufficient amount of Vitamin D (25 (OH) D > 30 ng/mL). The relationship between Vitamin D level and Basophil percentage were analysed using the one-way Anova test and Pearson correlation. A significant negative correlation was detected between Vitamin D levels and Basophil percentage (p =0.029, r = -0.626). In conclusion, there is a correlation between Vitamin D levels and Basophil percentage in patients with Atopic Dermatitis. Whereby the lower the Vitamin D level, the higher the Basophil percentage.
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2020/1/052001246 |
| Uncontrolled Keywords: | Dermatitis Atopik, Vitamin D, Basofil-Atopic Dermatitis, Vitamin D, Basophils |
| Subjects: | 600 Technology (Applied sciences) > 613 Personal health and safety > 613.2 Dietetics > 613.28 Specific nutritive elements > 613.286 Vitamins |
| Divisions: | Fakultas Kedokteran > Pendidikan Dokter |
| Depositing User: | soegeng sugeng |
| Date Deposited: | 10 Aug 2020 07:33 |
| Last Modified: | 22 Oct 2021 07:50 |
| URI: | http://repository.ub.ac.id/id/eprint/179979 |
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