Pradita, Refeny Meirine (2019) Pengaruh Pemberian Vitamin D terhadap Peningkatan Kadar Hemoglobin pada Mencit Model Ulcerative Colitis (UC). Sarjana thesis, Universitas Brawijaya.
Abstract
Pada penyakit Ulcerative Colitis (UC) terdapat manifestasi klinis anemia yang ditandai dengan penurunan kadar Hemoglobin. Penanganan UC juga masih terbatas pada obat-obatan anti inflamasi. Pada penderita UC sering ditemukan kadar vitamin D dalam tubuh yang menurun dan vitamin D sendiri diketahui memiliki hubungan dengan regulasi sitokin inflamasi dan proses erythropoiesis. Penelitian ini bertujuan membuktikan bahwa pemberian vitamin D dapat meningkatkan kadar hemoglobin pada mencit model UC. Studi eksperimental menggunakan randomized post test only control group design dilakukan terhadap hewan coba mencit BALB/c jantan. Sampel 21 ekor mencit dipilih dengan cara randomized sampling untuk dibagi dalam tiga kelompok, yaitu kelompok kontrol negatif (normal), kelompok kontrol positif (model UC) dan kelompok perlakuan (model UC dan diterapi vitamin D dosis 0,2 μg/25 gBB/hari). Variabel yang diukur adalah kadar hemoglobin dengan menggunakan hematology analyzer. Hasil penelitian menunjukkan kadar hemoglobin kelompok kontrol negatif sebesar 14,13 0,53 g/dL, kelompok kontrol positif sebesar 12,14 1,18 g/dL, kelompok perlakuan sebesar 13,86 0,77 g/dL. Hasil analisis data menunjukkan bahwa ada perbedaan kadar hemoglobin pada kelompok mencit model UC yang diterapi vitamin D dengan kelompok kontrol positif (p = 0.001). Kesimpulan dari penelitian ini adalah terdapat peningkatan kadar hemoglobin pada mencit UC yang diberi terapi vitamin D.
English Abstract
The disease of Ulcerative Colitis (UC) found clinical manifestations of anemia which is signed by the decrease of hemoglobin. Moreover, the management of Ulcerative Colitis is very limited, especially on anti-inflammatory medicine. However, Ulcerative Colitis sufferer are founded that the rate of vitamin D was decreased. Thus, Vitamin D has a relationship with regulation of inflammatory cytokines and the process of erythropoiesis. This research is aimed to prove that vitamin D treatment has an increasing rate of hemoglobin on mice role model of UC. An experimental study using randomizes post-test only control group design was conducted onto male mice (BALB/c). The samples of 21 mice are selected by randomized sampling and divided into three groups, those are negative control group (normal), positive control group (UC model), and treatment group (UC model and treated with vitamin D dose of 0.2 μg / 25 gBB / day). The variable measured was the level of hemoglobin by the blood test. The results showed that the hemoglobin level of the negative control group was 14.13 g / dL, the positive control group was 12.14 g / dL, the treatment group was 13.86 g / dL. Result of this research indicated that the treatment of Vitamin D on the UC model has shown significant different (P= 0,001). The conclusion of this research is that there is an increase in haemoglobin levels in UC that given vitamin D therapy.
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2019/424/052001290 |
| Uncontrolled Keywords: | ulcerative colitis, hemoglobin, vitamin D-ulcerative colitis, hemoglobin, vitamin D |
| Subjects: | 600 Technology (Applied sciences) > 613 Personal health and safety > 613.2 Dietetics > 613.28 Specific nutritive elements > 613.286 Vitamins |
| Divisions: | Fakultas Kedokteran > Pendidikan Dokter |
| Depositing User: | soegeng sugeng |
| Date Deposited: | 10 Aug 2020 07:44 |
| Last Modified: | 22 Oct 2021 06:56 |
| URI: | http://repository.ub.ac.id/id/eprint/179849 |
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