Maghfurina, Salis (2018) Pengaruh Pemberian Bawang Hitam terhadap Kadar Kolesterol Total Tikus Putih (Rattus norvegicus strain wistar) Jantan yang Diberi Diet Tinggi Lemak dan Fruktosa. Sarjana thesis, Universitas Brawijaya.
Abstract
Sindrom metabolik menjadi faktor risiko timbulnya penyakit degeneratif. Salah satu komponen terjadinya sindrom metabolik adalah dislipidemia yang ditandai dengan meningkatnya kadar kolesterol total, LDL, dan trigliserida, serta penurunan HDL. Peningkatan kadar kolesterol dapat dicegah dengan penggunaan bawang hitam yang mengandung SAC, polifenol, dan flavonoid. Tujuan dilakukannya penelitian ini untuk mengetahui pengaruh pemberian bawang hitam terhadap kadar kolesterol total tikus putih (Rattus norvegicus strain wistar) jantan yang diberi diet tinggi lemak dan fruktosa. Jenis penelitian yang digunakan adalah penelitian eksperimental menggunakan desain post test only controlled group design. Jumlah sampel sebanyak 25 ekor tikus yang dibagi menjadi 5 kelompok perlakuan, yaitu kelompok K1 (diet normal), kelompok K2 (diet normal dan DTLF), kelompok P1 (diet normal, DTLF, dan bawang hitam 240 mg), kelompok P2 (diet normal, DTLF, dan bawang hitam 480 mg), dan kelompok P3 (diet normal, DTLF, dan bawang hitam 960 mg). Perlakuan dilakukan selama 14 hari. Kadar kolesterol total tikus diukur menggunakan metode Cholesterol Oxidase/ Peroxidase dan hasilnya dianalisa secara statistik menggunakan uji One Way ANOVA. Hasil statistik menunjukkan terdapat perbedaan yang signifikan kadar kolesterol total tikus antar kelompok (p=0,018). Rata-rata kadar kolesterol total paling tinggi terdapat pada kelompok K1= 77,96±15,13 mg/dl, sedangkan kadar kolesterol total terendah terdapat pada kelompok P3= 53,8±5,8 mg/dl. Kesimpulan: pemberian bawang hitam mampu mencegah peningkatan kadar kolesterol total tikus yang diberi diet tinggi lemak dan fruktosa.
English Abstract
Metabolic syndrome is a risk factor for degenerative diseases. One manifestation component of metabolic syndrome is dyslipidemia characterized by elevated total cholesterol, LDL, and triglycerides also decreased levels of HDL. Increased cholesterol levels can be prevented by the use of black garlic containing SAC, polyphenols, and flavonoids. The purpose of this study was to determine the effect of black garlic on total cholesterol level of white male rats (Rattus norvegicus strain wistar) fed a high fat and fructose diet. The research was experimental research using 'post test only controlled group design'. The number of samples were 25 rats divided into 5 groups: K1 (normal diet), K2 (normal diet and high fat and fructose diet), P1 (normal diet, high fat and fructose diet and 240 mg of black garlic), P2 (normal diet, high fat and fructose diet and 480 mg of black garlic), and P3 (normal diet, high fat and fructose diet and 960 mg of black garlic). The treatments were performed for 14 days. Total cholesterol levels of rats were measured by Cholesterol Oxidase/ Peroxidase method and the results were statistically analyzed using One Way ANOVA test. The statistical results showed that there was a significant difference in total cholesterol levels among rats (p=0.018). The highest total cholesterol level was found in K1= 77.96±15.13 mg/dl, while the lowest total cholesterol level was in P3= 53.8±5.8 mg/dl. Conclusion: consumption of black garlic can prevent the increase in total cholesterol levels of rats fed a high fat and fructose diet.
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2018/240/051807267 |
| Uncontrolled Keywords: | bawang hitam, kadar kolesterol total, diet tinggi lemak dan fruktosa-black garlic, total cholesterol level, high fat and fructose diet |
| Subjects: | 600 Technology (Applied sciences) > 641 Food and drink > 641.3 Food > 641.35 Spesific food from plant crops |
| Divisions: | Fakultas Kedokteran > Ilmu Gizi |
| Depositing User: | soegeng sugeng |
| Date Deposited: | 06 May 2020 11:11 |
| Last Modified: | 21 Oct 2021 07:59 |
| URI: | http://repository.ub.ac.id/id/eprint/167328 |
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