Arinda, May Putri (2018) Pengaruh Kefir Susu Sapi Dalam Mencegah Peningkatan Kadar Malondialdehyde (Mda) Plasenta Pada Tikus (Rattus Novergicus) Bunting Yang Dipapar Asap Rokok. Sarjana thesis, Universitas Brawijaya.
Abstract
Pengaruh ibu selama kehamilan sebagian besar melalui plasenta, organ penting yang melakukan pertukaran nutrisi dan peredaran darah retoplasenter. Lingkungan yang buruk seperti paparan asap rokok sebagai radikal bebas akan meningkatkan ROS (Reactive Oxygen Species). Aktifitas radikal bebas dapat dicegah dan dihambat menggunakan antioksidan dari dalam maupun luar tubuh. Penelitian ini betujuan untuk membuktikan bahwa kefir susu sapi dapat mencegah peningkatan kadar MDA (Malondialdehyde) plasenta tikus bunting yang dipapar asap rokok. Penelitian ini bersifat eksperimental menggunakan rancangan penelitian Randomized Post Test Only Control Group Design. Sampel dibagi kedalam 2 kelompok kontrol dan 3 kelompok perlakuan. Kelompok kontrol negatif (-) adalah tikus bunting yang tidak dipapar asap rokok tanpa pemberian kefir susu sapi. sedangkan Kelompok kontrol positif (+) adalah tikus bunting yang dipapar asap rokok tanpa pemberian kefir susu sapi. Kelompok perlakuan yaitu tikus bunting yang dipapar asap rokok dengan pemberian kefir susu sapi dengan 3 dosis berbeda (P1=2,5; P2=5; P3=10 ml/kgBB/hari) selama 14 hari. Variabel penelitian adalah kadar MDA plasenta. Hasil penelitian secara signifikan menunjukkan kadar MDA plasenta pada kontrol (+) yaitu 0,90 ng/100mg lebih tinggi dibandingkan kontrol negatif (-) yaitu 0,24 ng/100mg (p = 0,000) (p < 0,05). Pada ketiga kelompok perlakuan (P1=0,58; P2=0,45; P3=0,46 ng/100mg) menunjukkan kadar MDA plasenta yang lebih rendah secara signifikan dibandingkan kontrol (+) (p = 0,000) (p < 0,05). Kefir susu sapi terbukti dapat mencegah peningkatan kadar MDA plasenta tikus yang dipapar asap rokok.
English Abstract
Maternal influences during pregnancy are mostly through the placenta, an important organ that performs the exchange of nutrients and blood circulation. Bad environments such as exposure to secondhand smoke as free radicals will increase ROS (Reactive Oxygen Species). Free radical activity can be prevented and inhibited using antioxidants from within and outside the body. This study aims to prove that kefir can prevent elevated levels of MDA (Malondialdehyde) placenta bunting mice exposed to cigarette smoke. This research is experimental using Randomized Post Test Only Control Group Design. Samples were divided into 2 control groups and 3 treatment groups. The negative control group (-) is a rat that is not exposed to cigarette smoke without giving kefir. whereas positive control group (+) is rat exposed to cigarette smoke without giving kefir. The treatment group was rat exposed to cigarette smoke by giving kefir with 3 different doses (P1 = 2.5, P2 = 5, P3 = 10 ml / kg BW / day) during 14 days. The research variable was placental MDA level. The results showed significant placental MDA level at control (+) ie 0.90 ng / 100mg higher than negative control (-) ie 0.24 ng / 100mg (p = 0,000) (p <0.05). Three treatment groups (P1 = 0.58; P2 = 0.45; P3 = 0.46 ng / 100mg) showed significantly lower placental MDA levels than control (+) (p = 0.000) (p <0, 05). Kefir is proven to prevent elevated levels of placental MDA of rat exposed to cigarette smoke
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2018/56/051803479 |
| Uncontrolled Keywords: | MDA, Kefir Susu Sapi, Asap Rokok, Kehamilan, MDA, Kefir, Cigarette Smoke, Pregnancy |
| Subjects: | 600 Technology (Applied sciences) > 641 Food and drink > 641.3 Food > 641.37 Dairy and related products > 641.371 476 Yogurt |
| Divisions: | Fakultas Kedokteran > Kebidanan |
| Depositing User: | Nur Cholis |
| Date Deposited: | 28 Oct 2019 03:41 |
| Last Modified: | 19 Oct 2021 06:08 |
| URI: | http://repository.ub.ac.id/id/eprint/167290 |
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