Kurniawati, Ika (2018) Efek Pemberian Suplemen Daun Seledri (Apium Graveolens) Terhadap Tekanan Darah Dan Profil Lipid Subyek Wanita Hipertensi. Magister thesis, Universitas Brawijaya.
Abstract
Hipertensi merupakan penyakit penyebab kematian nomor lima tertinggi di Indonesia. Selama ini penanganan hipertensi dilakukan dengan cara memberikan jenis obat seperti ACE Inhibitor, ß-blocker, calcium channel blocker, diuretic, dan α-blocker. Pengobatan tersebut dalam jangka panjang dapat menyebabkan efek samping seperti sakit kepala, batuk kering, kaki bengkak, merasa lelah, dan gangguan disfungsi seksual. Seledri merupakan salah satu jenis tanaman yang berpotensi sebagai penurun tekanan darah tinggi karena mengandung minyak atsiri 3-n-butylphthalide serta flavonoid jenis Apiin dan Apigenin. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh pemberian suplemen serbuk daun seledri terhadap tekanan darah dan profil lipid penderita hipertensi. 39 orang wanita penderita hipertensi tingkat 1 (sistol 140-159 mmHg dan diastole 90-99 mmHg) dengan usia 30-50 tahun direkrut dalam penelitian ini. Subyek dibagi menjadi dua grup secara random sehingga didapatkan 20 orang grup perlakuan (seledri) dan 19 orang grup kontrol (placebo). Setiap kelompok diberi 6 kapsul (@500 mg) per hari selama 7 minggu. Parameter klinik seperti tekanan darah diukur setiap hari, sedangkan profil lipid dan gula darah dianalisa sebelum dan sesudah perlakuan. Pada minggu ke 8 seluruh pelakuan dihentikan dan diukur tekanan darahnya di akhir minggu ke 8. Data yang diperoleh kemudian diuji dengan Statistical Package for the Social Sciences (SPSS) dengan tingkat kepercayaan 5%. Hasil penelitian menunjukkan setelah minggu ke 7, tekanan darah sistole mengalami penurunan sebesar 11,17% pada kelompok perlakuan dan 10,45% pada kelompok kontrol (placebo). Sedangkan tekanan darah diastole mengalami penurunan sebesar 14,91% pada kelompok perlakuan dan 13,74% pada kelompok kontrol. Walaupun terjadi penurunan tekanan darah pada kedua kelompok, akan tetapi penurunan tekanan darah pada kelompok perlakuan menunjukkan efek yang lebih stabil dibandingkan dengan kelompok kontrol. Pada minggu ke 8 (tanpa suplemen seledri) terjadi peningkatan tekanan darah sistol 3,87% pada kelompok perlakuan dan 4,23% pada kelompok kontrol. Penelitian ini belum secara nyata mengindikasikan manfaat suplemen serbuk daun seledri dalam memperbaiki profil lipid, khususnya dalam menurunkan kadar LDL dan kolesterol total. Pada pengujian profil lipid, trigliderida mengalami penurunan secara signifikan (α=0,05) pada kedua kelompok perlakuan. Under-reporting pada penulisan diet harian menyebabkan sulitnya penelusuran dan penjelasan fenomena yang terjadi pada perubahan profil lipid.
English Abstract
Hypertension is the fifth leading cause of death in Indonesia. So far, hypertension was treated by giving drugs such as ACE Inhibitor, ß-blocker, calcium channel blocker, diuretic, and α-blocker. This treatment in the long term can cause side effects such as headaches, dry cough, swollen feet, feeling tired, and sexual dysfunction. Celery is one type of plant that can be used to reduce high blood pressure. Essential oils of 3-n-butylphthalide as well as flavonoid of Apiin and Apigenin are compounds that play a role in decreasing blood pressure. The purpose of this study was to determine the effect of celery leaf supplementation on blood pressure, lipid profile and blood sugar of hypertensive patients. 39 women with hypertension level 1 (systolic blood pressure 140-159 mmHg and diastole blood pressure 90-99 mmHg) with age 30-50 years were recruited in this study. The subjects were divided into two groups randomly so that there were 20 treatment groups (celery) and 19 control groups (placebo). Each group was given 6 capsules (@ 500 mg) per day for 7 weeks. Clinical parameters such as blood pressure were measured daily, while lipid and blood sugar profiles were analyzed before and after treatment. At 8 weeks all treatment was stopped and blood pressure was measured at the end of week 8. The data obtained were then tested using Statistical Package for the Social Sciences (SPSS) with a 5% confidence level. The results showed that after 7 weeks, systolic blood pressure decreased by 11,17% in the treatment group and 10,45% in the control group (placebo). While diastole blood pressure decreased by 14,91% in the treatment group and 13,74% in the control group. Although there was a decrease in blood pressure in both groups, the decrease in blood pressure in the treatment group showed a more stable effect compared to the control group. At week 8 (without celery supplementation) there was an increase in systolic blood pressure of 3,87% in the treatment group and 4,23% in the control group. This study has not clearly indicated the benefits of celery leaf powder supplements in improving lipid profiles, especially in reducing LDL and total cholesterol levels. In testing the lipid profile, trigliderides significantly decreased (α = 0.05) in both treatment groups. Under-reporting on the writing of a daily diet causes difficulty in tracking and explaining the phenomena that occur in changes in lipid profiles.
| Item Type: | Thesis (Magister) |
|---|---|
| Identification Number: | TES/616.132/KUR/e/2018/041810465 |
| Uncontrolled Keywords: | HYPERFENSION |
| Subjects: | 600 Technology (Applied sciences) > 616 Diseases > 616.1 Diseases of cardiovascular system > 616.13 Diseases of blood vessels 600 Technology (Applied sciences) > 616 Diseases > 616.1 Diseases of cardiovascular system > 616.13 Diseases of blood vessels > 616.132 Hypertension |
| Divisions: | S2/S3 > Magister Teknologi Hasil Pertanian, Fakultas Teknologi Pertanian |
| Depositing User: | Sugeng Moelyono |
| Date Deposited: | 23 Jan 2020 02:46 |
| Last Modified: | 28 Dec 2021 07:34 |
| URI: | http://repository.ub.ac.id/id/eprint/178260 |
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