Andriani, Fety (2018) Nanoenkapsulasi 2- Sitronelil Benzimidazol Menggunakan Penyalut Gelatin dan Uji Aktivitasnya sebagai Antibakteri. Sarjana thesis, Universitas Brawijaya.
Abstract
Senyawa 2-sitronelil benzimidazol merupakan senyawa turunan benzimidazol yang bersifat antibakteri. Dalam penelitian ini 2- sitronelil benzimidazol dibuat nanokapsul menggunakan penyalut gelatin-glutaraldehid. Pembuatan nanokapsul dilakukan dengan variasi massa penyalut lalu dihitung % efisiensi nanoenkapsulasi. Produk nanokapsul dengan efisiensi tertinggi yaitu 56,25% pada penggunaan 3 g penyalut gelatin. Produk nanokapsul dikarakterisasi menggunakan Spektrofotometer FT-IR, PSA dan SEM. Pelepasan 2- sitronelil benzimidazol dari nanokapsul pada waktu 15-60 menit cenderung konstan. Produk nanokapsul diuji aktivitas antibakterinya terhadap bakteri EPEC (Enteropathogenic Escherichia coli) dan bakteri Staphylococcus aureus. Zona hambat ditunjukan dengan terbentuknya zona bening dengan rentang diameter 4-12 mm. Zona hambat nanokapsul 2-sitronelil benzimidazol terhadap bakteri digolongkan sedang hingga kuat.
English Abstract
The 2-citronellyl benzimidazole is a compound class of benzimidazole derivatives which has antibacterial activity. This study investigate encapsulation of 2-citronellyl benzimidazole using gelatin-glutaraldehyde. Preparation of nanocapsul done by variation of coating mass then calculated nanoencapsulation efficiency. The result give the highest efficiency in 56.25% by using 3 g of gelatin coating. Nanocapsule product was characterized using FT-IR Spectrophotometer, PSA and SEM. In addition, the release profiles of encapsulated 2-citronellyl benzimidazole is determined based on solvation on methanol solvent. The release of 2-citronellyl benzimidazole at 15-60 min tends to be constant. Nanocapsule product used to determine antibacterial activity against EPEC (Enteropathogenic Escherichia coli) bacteria and Staphylococcus aureus bacteria. The inhibitory zone is indicated by the formation of a clear zone with a 4-12 mm diameter range. The 2-citronellyl benzimidazole nanocapsule inhibition zone of bacteria is classified as moderate to strong.
Other obstract
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| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/MIPA/2018/379/051807954 |
| Uncontrolled Keywords: | nanoenkapsulasi, 2-sitronelil benzimidazol, gelatin, profil pelepasan, antibakteri, nanoencapsulation, 2-citronellyl benzimidazole, gelatin, release profiles, antibacterial. |
| Subjects: | 600 Technology (Applied sciences) > 664 Food technology > 664.2 Starches and jellying agents > 664.26 Gelatin / Gelatin industry |
| Divisions: | Fakultas Matematika dan Ilmu Pengetahuan Alam > Kimia |
| Depositing User: | Nur Cholis |
| Date Deposited: | 21 Jul 2020 03:51 |
| Last Modified: | 22 Oct 2021 22:31 |
| URI: | http://repository.ub.ac.id/id/eprint/168796 |
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