Atmajawati, SeftriaNurul (2015) Terapi Air Rebusan Kedelai (Glycine Max (L) Merril ) Pada Tikus (Rattus Norvegicus) Model Fibrosis Ginjal Pasca Induksi Streptokinase Terhadap Kadar Malondialdehid (Mda) Ginjal Dan Gambar. Sarjana thesis, Universitas Brawijaya.
Abstract
Fibrosis Ginjal Merupakan Keadaan Dimana Ginjal Mengalami Akumulasi Matriks Ekstra Seluler Yang Berlebih. Air Rebusan Kedelai Mengandung Zat Aktif Yang Berperan Sebagai Antioksidan. Pada Penelitian Ini Penyiapan Hewan Tikus Model Fibrosis Ginjal Dilakukan Dengan Induksi Streptokinase. Pemberian Air Rebusan Kedelai Digunakan Sebagai Terapi Fibrosis Ginjal. Tujuan Penelitian Ini Ialah Mengetahui Penurunan Kadar Mda Ginjal Dan Perbaikan Gambaran Histopatologi Hati Setelah Mendapatkan Terapi Air Rebusan Kedelai Pada Tikus Model Fibrosis Ginjal Yang Diinduksi Streptokinase. Penelitian Ini Terdapat 4 Kelompok Perlakuan Yaitu Kontrol Negatif (A), Kontrol Positif (B), Terapi Dosis 6 G/Ekor (C) Dan Dosis 9 G/Ekor (D). Induksi Streptokinase Secara Intravena Pada Vena Coccygea, Dengan Dosis Streptokinase 6000 Iu/Ekor Tikus Pada Hari 1, 6 Dan 11. Pengukuran Mda Menggunakan Metode Tba (Thiobarbituric Acid) Dan Gambaran Histopatologi Hati Diamati Secara Mikroskopis Dengan Pewarnaan He. Hasil Penelitian Menunjukkan Pemberian Terapi Air Rebusan Kedelai Menurunkan Kadar Mda Dan Memperbaiki Gambaran Histopatologi Hati Secara Signifikan (P<0,05) Antar Perlakuan. Dosis Terapi 9 G/Ekor Merupakan Dosis Efektif Dan Memberikan Hasil Terbaik Terhadap Penurunan Kadar Mda Dan Perbaikan Histopatologi Hat
English Abstract
Renal Fibrosis Is A Condition Where Extra Cellular Matrix On The Kidneys Had An Accumulation Of Excess. Soybean Stewed Water Is Containing An Active Substance That Act As An Antioxidant. Preparation Of Renal Fibrosis Rats Is Done By Streptokinase Induction. The Provision Of Soybean Stewed Water Used As Therapy Of Renal Fibrosis. The Purpose Of This Study Is To Find Out A Decrease In Levels Of Kidney Mda And Increased Liver Histopathology After Soybean Stewed Water Given As Therapy In Rats Models Of Renal Fibrosis Has Been Induced Streptokinase. In This Study, Rats Model Were Divided Into 4 Groups: Negative Control Group (A), Positife Control Group (B), Therapy Group With Dose Of 6 Grams/Rat (C) And 9 Grams/Rat (D). Induction Of Streptokinase Is Done On Intravenous In The Coccygeal Vein, At A Dose Of 6000 Iu/Rat On Days 1, 6 And 11. The Parameters Of Mda Levels Was Observed By Tba (Thiobarbituric Acid) Methods And Histopathological Of Liver Was Observed By Microscopy With He Staining. The Results Showed That Soybean Stewed Water Therapy Is Resulting In A Decreasing Levels Of Mda And Improving Liver Histopathology Was Significantly (P<0.05) Between Treatments. The Therapeutic Dose Of 9 Grams/Rat Is A Dose Of Effective And Gives The Best Result To The Decreased Levels Of Mda And Improvement Of Liver Histopathology.
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FKH/2015/10/051503289 |
| Subjects: | 600 Technology (Applied sciences) > 636 Animal husbandry > 636.08 Specific topics in animal husbandry > 636.089 Veterinary medicine |
| Divisions: | Fakultas Kedokteran Hewan > Kedokteran Hewan |
| Depositing User: | Budi Wahyono Wahyono |
| Date Deposited: | 26 May 2015 07:52 |
| Last Modified: | 19 Oct 2021 07:23 |
| URI: | http://repository.ub.ac.id/id/eprint/126967 |
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