Imamah, Syarifatul (2014) Pengaruh Penambahan Alpha Lipoic Acid terhadap Stabilitas Asam Askorbat dalam Sediaan Krim dengan Metode Temperature Stress Test. Sarjana thesis, Universitas Brawijaya.
Abstract
Vitamin C merupakan salah satu vitamin dapat diformulasikan dalam produk kecantikan sebagai agen antioksidan topikal. Namun vitamin C tidak stabil dalam larutan berair karena sangat mudah teroksidasi. Stabilitas vitamin C dapat ditingkatkan dengan penambahan antioksidan lain seperti alpha lipoic acid (ALA). ALA dapat meningkatkan stabilitas vitamin C dengan meregenerasi vitamin C. Penelitian ini bertujuan untuk mengetahui pengaruh ALA terhadap stabilitas vitamin C dan konsentrasi optimum yang digunakan dalam krim. Penelitian dilakukan dengan menggunakan metode temperature stress test. Digunakan perhitungan waktu paruh (t1/2) dan waktu kadaluarsa (t90) untuk mengetahui pengaruh ALA terhadap stabilitas vitamin C dalam krim. Hasil penelitian menunjukkan bahwa penambahan ALA sebesar 0,3% memiliki t1/2 ±12 kali dan t90 ±13 kali dibanding kontrol, ALA sebesar 0,5% memiliki t1/2 ±2 kali dan t90 ±2 kali dibanding kontrol, ALA sebesar 0,7% memiliki t1/2 ±0,5 kali dan t90 0,75 kali dibanding kontrol. Kesimpulan dari penelitian ini adalah ALA dapat meningkatkan stabilitas vitamin C dalam sediaan krim dengan konsentrasi optimum sebesar 0,3%.
English Abstract
Vitamin C is one of a vitamin that can be formulated in beauty products as an topical antioxidant. However, vitamin C is unstable in aqueous solution because it easy to oxidized. Stability of vitamin C can be enhanced by addition of other antioxidants such as alpha lipoic acid (ALA). ALA used for regeneration of vitamin C and increased their stability. This research was aimed to determine the effect of ALA in stability of vitamin C and optimum concentration in cream. This research used temperature stress test method. Calculation of the half-life (t1/2) and expired date (t90) used to determine the effect of ALA in the stability of vitamin C in cream. The results showed that addition of 0.3% of ALA had t1/2 ±12 times higher and t90 13 times higher than control, addition of 0.5% ALA had t1/2 ±2 times higher and t90 ±2 times higher than control, addition of 0.7% ALA had t1/2 ±0,5 times and t90 0,75 times than control. The conclusion of this research is ALA can enhance the stability of vitamin C in a cream with an optimum concentration of 0.3%.
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2014/490/051403761 |
| Subjects: | 600 Technology (Applied sciences) > 615 Pharmacology and therapeutics > 615.1 Drugs (materia medica) |
| Divisions: | Fakultas Kedokteran > Farmasi |
| Depositing User: | Budi Wahyono Wahyono |
| Date Deposited: | 11 Jul 2014 10:28 |
| Last Modified: | 22 Oct 2021 01:40 |
| URI: | http://repository.ub.ac.id/id/eprint/124490 |
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