Alkaf, Amalia Istiqamah (2018) Pengaruh Pemberian Peptida Polisakarida (PSP) Ganoderma Lucidum Terhadap Jumlah Vasa Vasorum Pada Tikus (Rattus Norvegicus) Model Diabetes Mellitus Tipe 2. Sarjana thesis, Universitas Brawijaya.
Abstract
Diabetes mellitus ialah kondisi resistensi insulin sehingga terjadi hiperglikemia yang akan menyebabkan terjadinya vascular damage akibat stress oksidatif dan proinflamasi. Proses inflamasi dan stress oksidatif memicu hipoksia sel menghasilkan peningkatan HIF-1α dan VEGF sehingga memicu angiogenesis vasa vasorum. Kandungan Polipeptida Polisakarida pada jamur Ganoderma lucidum memiliki efek antiangiogenesis pada jaringan aorta tikus dengan diabetes sehingga dapat mencegah terjadinya angiogenesi yang patologis. Penelitian dengan menggunakan Randomized Post Test Control Group Design menggunakan 25 tikus Wistar (Rattus Norvegicus) yang terbagi dalam 5 kelompok : kelompok normal, kelompok diet hiperkolesterol, serta 3 kelompok diet hiperkolesterol dengan pemberian dosis PSP yang berbeda-beda yaitu, 50 mg/kgBB, 150 mg/kgBB, 300 mg/kgBB. Hasil penelitian menggunakan ANOVA test (p < 0,05) menunjukkan bahwa terdapat pengaruh yang signifikan polipeptidasakarida terhadap penurunan jumlah vasavasorum (p = 0.00). Kesimpulan dari penelitian ini PSP Ganoderma lucidum adalah agen antiangiogenesis vasa vasorum aterosklerosis pada pasien dengan diabetes mellitus tipe 2.
English Abstract
Diabetes mellitus is a condition of insulin resistance resulting in hyperglycemia that will cause vascular damage due to oxidative stress and proinflammation. Inflammatory processes as well as oxidative stress can cause cell hypoxia resulting in increased expression of HIF-1α and VEGF that will trigger vasa vasorum angiogenesis. Polysaccharide peptide on Ganoderma lucidum has antiangiogenesis effect on rat aortic tissue with diabetes so as to prevent pathologic angiogenesis. True experimental laboratory with randomized post test control group design using 25 Wistar rats (Rattus Norvegicus) divided into 5 groups: normal group, hypercholesterol diet group, and 3 groups of hypercholesterol diet with different doses of PSP that is 50 mg/kgBW, 150 mg/kgBW, 300 mg/kgBW. The results of the study using ANOVA test (p < 0,05) showed that there was significant polysaccharide peptide effect on decreasing vasa vasorum (p = 0.00). The conclusion of this study PSP Ganoderma lucidum is a vasa vasorum antiangiogenesis agent in patients with diabetes mellitus type 2.
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2017/547/051801275 |
| Uncontrolled Keywords: | Aterosklerosis, Diabetes Mellitus, Vasa Vasorum, Angiogenesis, Ganoderma Lucidum |
| Subjects: | 500 Natural sciences and mathematics > 572 Biochemistry > 572.5 Miscellaneous chemicals > 572.56 Carbohydrates > 572.566 Polysaccharides |
| Divisions: | Fakultas Kedokteran > Pendidikan Dokter |
| Depositing User: | Yusuf Dwi N. |
| Date Deposited: | 11 Apr 2018 07:00 |
| Last Modified: | 26 Oct 2021 03:09 |
| URI: | http://repository.ub.ac.id/id/eprint/9367 |
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