Mukarromah, Tsamaroh Azzah and Dr. Nurul Muslihah, SP., M.Kes and Adelya Desi Kurniawati, STP., MP., M.Sc. (2021) Narrative Review: Potensi Daun Sirsak (Annona Muricata L) sebagai Sumber Antioksidan, Antiinflamasi, dan Antidiabetes. Sarjana thesis, Universitas Brawijaya.
Abstract
Daun sirsak (Annona muricata L) merupakan salah satu bagian dari tanaman sirsak yang terkenal kaya akan khasiatnya. Di Indonesia dan negara lain, daun sirsak digunakan sebagai obat herbal untuk pengobatan kanker, rematik, diabetes, hipertensi, dan diare. Penelitian ini bertujuan untuk mengetahui potensi daun sirsak sebagai sumber antioksidan, antiinflamasi, dan antidiabetes berdasarkan tinjauan pustaka. Penelitian ini menggunakan pendekatan narrative review. Penelusuran literatur menggunakan database: EBSCO, Science Direct, PubMed Central, dan ProQuest. Hasil penelitian menunjukkan bahwa daun sirsak berpotensi sebagai antioksidan dengan cara (1) menghambat peroksidasi lipid; (2) menurunkan kadar ROS; dan (3) efek anti-ulcer yang menghambat proses ulserasi. Daun sirsak juga berpotensi sebagai antiinflamasi dengan cara (1) meningkatkan kadar IL-10 sebagai sitokin antiinflamasi; (2) menekan produksi NO dan PLA2; dan (3) melakukan penyembuhan luka melalui peningkatan ekspresi protein Hsp70 dan serat kolagen. Daun sirsak juga berpotensi sebagai antidiabetes dengan cara (1) menghambat aktivitas α-amilase dan α-glukosidase; (2) menurunkan kadar glukosa darah; (3) meningkatkan aktivitas SOD dan katalase; (4) meningkatkan aktivitas anti-glikasi; dan (5) dan menurunkan profil lipid (kolesterol total, LDL, TG, VLDL, HDL). Dapat disimpulkan bahwa daun sirsak berpotensi sebagai sumber antioksidan, anti inflamasi, dan anti diabetes.
English Abstract
Soursop leaf (Annona muricata L) is a part of the soursop plant which is known for its rich benefits. In Indonesia and other countries, soursop leaves are used as herbal medicine for the treatment of cancer, rheumatism, diabetes, hypertension, and diarrhea. This study aimed to examine the potential of soursop leaves as a source of antioxidants, anti-inflammatory, and anti-diabetic based on a literature review. The study used a narrative literature review approach. The literature searching used databases: EBSCO, Science Direct, PubMed Central, and ProQuest. The results showed that soursop leaves have the potential as antioxidants by (1) inhibiting lipid peroxidation; (2) lowering ROS levels, and (3) anti-ulcer effect that inhibiting the ulceration process. Soursop leaves also have the potential as an anti-inflammatory by (1) increasing levels of IL-10 as an anti-inflammatory cytokine; (2) suppressing NO and PLA2 production; and (3) perform wound healing by increasing the expression of Hsp70 protein and collagen fibers. Soursop leaves also have the potential as antidiabetic by (1) inhibiting the activity of α-amylase and α-glucosidase; (2) lowering blood glucose levels; (3) increasing the activity of SOD and catalase; (4) enhancing anti-glycation activity; and (5) and lowering lipid profile (total cholesterol, LDL, TG, VLDL, HDL). It can be concluded that soursop leaves have the potential as a source of antioxidants, anti-inflammatory, and anti-diabetic.
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | 0521060212 |
| Uncontrolled Keywords: | Daun sirsak, antioksidan, antiinflamasi, antidiabetes, Soursop leaves, antioxidant, anti-inflammatory, anti-diabetic |
| Subjects: | 600 Technology (Applied sciences) > 613 Personal health and safety |
| Divisions: | Fakultas Kedokteran > Ilmu Gizi |
| Depositing User: | Budi Wahyono Wahyono |
| Date Deposited: | 27 Dec 2021 07:11 |
| Last Modified: | 25 Sep 2024 01:25 |
| URI: | http://repository.ub.ac.id/id/eprint/187649 |
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