Arvianti, Militanisa Zamzara (2019) Pengaruh Kombinasi Monosodium Glutamat dan Diet Tinggi Lemak Terhadap Berat Lemak Visceral Pada Tikus Wistar (Rattus novergicus) Dewasa. Sarjana thesis, Universitas Brawijaya.
Abstract
Saat ini, makanan tinggi lemak cenderung seringkali disajikan bersamaan dengan penambahan MonosodiumiGlutamat (MSG). Banyak penelitian yang telah dilakukan mengenai pengaruh pemberian Diet Tinggi Lemak (DTL) maupun MSG terhadap beratibadanihewanicoba. Pemberian DTL meningkatkan beratibadanihewanicoba, sedangkan pada pemberian MSG terdapat kontroversi mengenai pengaruh pemberian MSG terhadap hewan coba. Studi sebelumnya mengklaim bahwa MSG menginduksi obesitas. Namun, penelitian terbaru telah mulai mengubah gambaran ini, dimana hasilnya menunjukkan penurunan berat badan hewan coba. Penelitianiini bertujuaniuntuk mengetahuiipengaruh pemberianikombinasi DTL dan MSG terhadap berat lemak visceral tikus wistar dewasa. Penelitian ini dilakukan selama 56 hari dengan menggunakan 30 tikus Rattus novergicus strainiwistar yangidibagi menjadi 6 kelompokiyaitu kelompokikontrol (-), Kontrol (+) 1 DTL, Kontrol (+) 2 MSG 0,70mg/gBB, Perlakuan 1 (DTL + MSG 0,05mg/gBB), Perlakuan 2 (DTL + MSG 0,20mg/gBB), dan Perlakuan 3 (DTL + MSG 0,35mg/gBB). Hasil penelitian menunjukkan perbedaan berat lemak visceral yang signifikan antara kelompok kombinasi DTL dan MSG dengan kelompok kontrol negatif (p = 0,00). Perbedaan berat lemak visceral terjadi secara signifikan pada kelompok Perlakuan 3 (DTL + MSG 0,35mg/gBB) dengan kelompok kontrol (+) 1 DTL (p = 0,032). Kesimpulan dari penelitian ini adalah pemberian kombinasi DTL dengan MSG meningkatkan berat lemak visceral, namun pemberian MSG cenderung menurunkan berat lemak visceral sebanding dengan dosis MSG yang diberikan.
English Abstract
Nowadays, high-fat diet mostly served together with MonosodiumiGlutamate (MSG). Much research has been done on the High Fat Diet (DTL) and MSG on body weight of experimental animals. The provision of DTL increases the body weight of the trial, whereas in the provision of MSG there is controversy regarding the provision of MSG assistance to experimental animals. Previous studies claim that MSG induces obesity. However, recent research has begun to change this picture, where the results show a decrease in body weight of experimental animals. Thisistudy aimsito determineithe combination of DTL and MSG on the visceral fat weight of adult wistar rats. The research was carried out for 56 days using 30 Rattus novergicus strains of Wistaristrain whichiwereidivided intoi6 groupsinamely control group (-), Control (+) 1 DTL, Control (+) 2 MSG 0.70mg / gBB, Treatment 1 (DTL + MSG 0.05mg / gBB), Treatment 2 (DTL + MSG 0.20 mg / gBB), and Treatment 3 (DTL + MSG 0.35 mg / gBB). The results showedia significantidifference in fat weight betweenithe DTL and MSG combination groups and theinegativeicontrol group (p = 0.00). The difference in fat weight occurred in the Treatment group 3 (DTL + MSG 0.35mg / gBB) with the control group (+) 1 DTL (p = 0.032). Theiconclusion of thisistudyiis that the combination of DTL with MSG increases the visceral fat weight, but the administration of MSG increases the visceral fat weight proportional to the dose of MSG given.
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2019/409/052001254 |
| Uncontrolled Keywords: | Monosodium Glutamat, Diet Tinggi Lemak, Berat Lemak Visceral-Monosodium Glutamate, High Fat Diet, Visceral Fat Weight |
| Subjects: | 600 Technology (Applied sciences) > 613 Personal health and safety > 613.2 Dietetics |
| Divisions: | Fakultas Kedokteran > Pendidikan Dokter |
| Depositing User: | Sugeng Moelyono |
| Date Deposited: | 19 Jul 2020 07:20 |
| Last Modified: | 22 Oct 2021 07:26 |
| URI: | http://repository.ub.ac.id/id/eprint/179990 |
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