Fitria, Luthfi Rahma (2019) Pengaruh Ekstrak Kopi Amstirdam terhadap Ekspresi NF-. Sarjana thesis, Universitas Brawijaya.
Abstract
Diet tinggi lemak dan fruktosa merupakan pola konsumsi yang dapat mengakibatkan akumulasi lemak dalam tubuh dan memicu aterosklerosis. Aterosklerosis dapat berujung pada berbagai penyakit kardiovaskular seperti serangan jantung dan stroke. Penanganan aterosklerosis umumnya menggunakan obat yang mengandung senyawa statin, akan tetapi senyawa ini dapat menimbulkan efek samping hingga memicu cholestasis dan kerusakan liver akut. Tujuan penelitian ini yaitu mengetahui pengaruh perlakuan kopi Asmtirdam yang diduga dapat berpotensi sebagai obat alternatif untuk aterosklerosis yang ditunjukkan dengan profil lipid serta ekspresi NF-
English Abstract
High fat and fructose diet can lead to fat accumulation in the body and trigger atherosclerosis. Atherosclerosis leads to various cardiovascular diseases such as heart attacks and strokes. Treatment of atherosclerosis generally uses drugs contain statin compounds, but these compounds cause side effects trigger cholestasis and acute liver damage. The aim of this study is to determine the effect of Asmtirdam coffee treatment for atherosclerosis indicated by the lipid profile, NF-danB and TNF-α expression of CD 4+ T cells in High Fat Fructose Diet animal model. This study was conducted for 5 months with the induction method of High Fat Fructose Diet (HFFD) and treatment of coffee extract for 2 weeks which was divided into 3 doses. Spleen was isolated as a sample for analysis of CD 4+, TNF-α, and NF-
Other obstract
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| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/MIPA/2019/470/052001634 |
| Uncontrolled Keywords: | aterosklerosis, High Fat Fructose Diet, Kopi Amstirdam, sel T CD4+. atherosclerosis, High Fat Fructose Diet, NF- |
| Subjects: | 500 Natural sciences and mathematics > 572 Biochemistry > 572.5 Miscellaneous chemicals > 572.57 Lipids |
| Divisions: | Fakultas Matematika dan Ilmu Pengetahuan Alam > Biologi |
| Depositing User: | Budi Wahyono Wahyono |
| Date Deposited: | 02 Oct 2020 02:44 |
| Last Modified: | 02 Oct 2020 02:44 |
| URI: | http://repository.ub.ac.id/id/eprint/179214 |
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