Oktaviani, Diah Novida (2019) Pengaruh Pemberian Diet HFHF (High Fat High Fructose) Terhadap Gambaran Histopatologi Jantung Pada Tikus Sprague Dawley Jantan. Sarjana thesis, Universitas Brawijaya.
Abstract
Obesitas sering dikaitkan dengan kondisi inflamasi kronis yang dapat menyebabkan kerusakan pada jantung. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian diet HFHF (High Fat High Fructose) terhadap gambaran histopatologi Jantung pada Tikus Sprague Dawley Jantan. Penelitian ini adalah studi eksperimental menggunakan randomized control grup posttest design. Subjek penelitian adalah tikus Sprague Dawley yang dipelihara selama 17 minggu di Laboratorium Biosains Universitas Brawijaya yang dibagi menjadi 2 kelompok yaitu kelompok yang diberi diet normal standar AIN-93 dan diet HFHF (High Fat High Fructose) dengan jumlah total 36 tikus. Gambaran histolopatologi jantung meliputi jumlah sel inflamasi mononuklear, hipertrofi dan fibrosis. Analisis data menggunakan Independent T-test. Hasil penelitian menunjukkan terdapat perbedaan jumlah sel inflamasi mononuklear (p=0,00) dan hipertrofi (p=0,00). Jumlah sel inflamasi mononuklear pada diet normal standar AIN-93M sebesar 40,42 ± 4,12 lebih rendah dibandingkan dengan diet HFHF (High Fat High Fructose) sebesar 48,81 ± 5,05. Demikian pula dengan ukuran sel pada diet normal standar AIN-93M sebesar 507,53 ± 37,59 lebih rendah dibandingkan dengan diet HFHF (High Fat High Fructose) sebesar 539,52 ± 23,76. Pada diet HFHF (High Fat High Fructose) didapatkan pula adanya fibrosis. Kesimpulan penelitian ini adalah pemberian diet HFHF mempengaruhi gambaran histopatologi jantung yang ditandai dengan peningkatan sel inflamasi mononuklear, hipertrofi dan adanya fibrosis.
English Abstract
Obesitas is often associated with chronic inflammatory conditions that can cause damage to the cardiac. This research is amed to know the description of effect of HFHF diet (High Fat High Fructose) to cardiac histopathology of male Sprague Dawley rat. Experimental study using randomized control group posttest design was this type. This research is experimental studies using randomized control group posttest design. The subject of research is the rat Sprague Dawley maintained for 17 weeks in the laboratory Bioscience Brawijaya University are divided into 2 groups, the Group given standard normal diet AIN-93 HFHF and diet (High Fat High Fructose) with the total 36 rats. The description of the histolophthology the csrdiac includes the amount of inflammatory cell mononuklear, hypertrophy and fibrosis. Data analysis using Independent T-test. The results showed there is a difference of inflammatory cell number mononuclear (p = 0.00) and hypertrophy (p = 0.00). Inflammatory cell number mononuclear in standard normal diet AIN-93M of 40.42 ± 4.12 lower compared with diet HFHF (High Fat High Fructose) of 48.81 ± 5.05. Similarly, the size of the cells on normal diet 93M-standard AIN of 507.53 ± 37.59 lower compared with diet HFHF (High Fat High Fructose) of 539.52 ± 23.76. HFHF diet (High Fat High Fructose) also brings about the presence of fibrosis. Conclusion of this research is the awarding of HFHF diet affects the image of the histopathology of the heart which is characterized by an increase in inflammatory cell mononuclear, hypertrophy and fibrosis.
Other obstract
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| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2019/280/051909371 |
| Uncontrolled Keywords: | Obesitas, diet HFHF (High Fat High Fructose), Histopatologi Jantung, Obesity, HFHF diet (High Fat High Fructose), Histopathology of the cardiac |
| Subjects: | 600 Technology (Applied sciences) > 616 Diseases > 616.3 Diseases of digestive system > 616.39 Nutritional and metabolic diseases > 616.398 Obesity > 616.398 06 Obesity--Treatment |
| Divisions: | Fakultas Kedokteran > Ilmu Gizi |
| Depositing User: | Budi Wahyono Wahyono |
| Date Deposited: | 19 Jul 2020 05:22 |
| Last Modified: | 22 Oct 2021 03:57 |
| URI: | http://repository.ub.ac.id/id/eprint/176035 |
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