Mutiarahmi, Marlina (2019) Pengaruh Diet Tinggi Kolesterol terhadap Kadar Asam Urat Tikus Putih Bunting. Sarjana thesis, Universitas Brawijaya.
Abstract
Kolesterol dari diet tinggi kolesterol dan penambahan lipid selama kehamilan akan meningkatkan kadar lipid dalam darah. Lipid tersebut selanjutnya akan di metabolisme, sementara lipid dalam jumlah yang tinggi akan meningkatkan metabolisme lemak sehingga meningkatkan benda keton (ketosis) yang merupakan hasil samping dari metabolisme lemak. Benda keton dalam jumlah banyak akan menyebabkan inhibisi kompetitif terhadap ekskresi benda keton dan benda lain di ginjal, salah satunya adalah asam urat. Keadaan ini akan menyebabkan hiperurisemia, dimana asam urat darah diatas 6,0 mg/dL (wanita) dan 7,0 mg/dL (pria). Metode penelitian ini menggunakan true experiment dengan 18 tikus putih bunting sebagai sampel. Selanjutnya sampel dibagi menjadi kelompok kontrol dan perlakuan. Kelompok kontrol diberikan pakan standar sementara kelompok perlakuan diberikan pakan tinggi kolesterol selama 18 hari kebuntingan, berat badan tikus putih bunting akan ditimbang setiap hari selama 18 hari kebuntingan. Pada hari ke-19 kebuntingan, tikus dibedah dan diambil darahnya untuk dilakukan pemeriksaan kadar asam urat dan kolesterol. Hasil penelitian menunjukkan bahwa pemberian diet tinggi kolesterol tidak memberikan perbedaan berat badan yang signifikan (p=0,459) namun terdapat perbedaan kadar kolesterol (p=0,014) dan asam urat (p=0,027) yang signifikan diantara kedua kelompok.
English Abstract
Cholesterol from high cholesterol diet and high lipid metabolism during pregnancy will increase lipid level in blood serum. Increased lipid metabolism will produce high amount of ketone. Which will later, cause competitive inhibition between ketone and other substances excretion in the kidney, including uric acid. This condition will lead to hyperuricemia (high uric acid level in blood serum). Normal plasma uric acid level in woman is 6,0 mg/dL and in man 7,0 mg/dL. This study used the method of true experiment with randomized post test only group design. 18 Pregnant white rats used as samples in this study. It was divided into two groups (control and treatment).For 18 days of pregnancy, control group was given standard diet, while treatment group received high cholesterol diet. Body weight was measured every day for those 18 days. On day 19, rats were sacrificed, and their blood was taken for uric acid and cholesterol measurement. This study shows a result that high cholesterol diet made no significant difference in body weight for both groups (p=0,459), but it made a significant difference in cholesterol level (p=0,014) and uric acid level (p=0,027) in both groups.
Other obstract
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| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2019/182/051909349 |
| Uncontrolled Keywords: | diet tinggi kolesterol, kadar asam urat, tikus putih bunting. high cholesterol diet, uric acid level, pregnant white rats |
| Subjects: | 600 Technology (Applied sciences) > 613 Personal health and safety > 613.2 Dietetics |
| Divisions: | Fakultas Kedokteran > Kebidanan |
| Depositing User: | Budi Wahyono Wahyono |
| Date Deposited: | 19 Jul 2020 04:47 |
| Last Modified: | 14 Mar 2022 02:54 |
| URI: | http://repository.ub.ac.id/id/eprint/175334 |
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