Vijayadas, Dinesh (2018) Analysis Of Correlation Between Concentration Of Lp-Pla2 (Lipoprotein-Associated Phospholipase A2) And The Number And Percentage Of Monocyte On Population With Conditions At Risk Of Atherosclerosis. Sarjana thesis, Universitas Brawijaya.
Abstract
Aterosklerosis merupakan salah satu penyebab utama penyakit vaskular di seluruh dunia dan menyebabkan progresi penyakit klinis seperti serangan jantung, stroke, dan kematian. Lp-PLA2 merupakan enzim yang diproduksi sel-sel inflamasi dan bersifat pro aterogenik pada proses aterosklerosis. Dalam prosesnya, monosit akan menginduksi penghasilan Lp-PLA2. Lp-PLA2 akan menghidrolisi oxLDL dan menghasilkan lysophosphatidylcholine (lysoPC) dan oxidized fatty acids (oxFA) yang memperberatkan aterosklerosis. Penelitian ini bertujuan untuk mengetahui korelasi konsentrasi Lp-PLA2 dengan monosit pada populasi dengan kondisi risiko aterosklerosis. Penelitian ini deskriptif analitik korelasional pada populasi dengan kondisi risiko aterosklerosis. Sampling dilakukan dengan metode total sampling dengan responden sejumlah 86 orang. Lp-PLA2 diukur menggunakan metode ELISA sedangkan monosit diukur menggunkan Hematology Analyzer. Hasil penelitian menunjukkan bahwa terdapat korelasi yang signifikan antara Lp-PLA2 dengan monosit (p=0,028;a<0,050) dan koefisien korelasinya adalah 0,789. Kesimpulan dari penelitian ini adalah peningkatan konsentrasi Lp-PLA2 berkorelasi dengan peningkatan monosit pada populasi dengan resiko aterosklerosis.
English Abstract
Atherosclerosis is one of the main causes of vascular disease throughout the world and cause clinical disease progressions such as heart attack, stroke, and lead to death. Lp-PLA2 is an enzyme produced by inflammatory cells and pro atherogenic in the process of atherosclerosis. In the process, monocytes will produce Lp-PLA2. LpPLA2 will hydrolyze oxLDL into lysophosphatidylcholine (lysoPC) and oxidized fatty acids (oxFA) which are atherogenic. Aim of the research is to determine the correlation of Lp-PLA2 concentration with number and percentages in populations with conditions at risk of atherosclerosis. This study was descriptive correlational analytic on the population with conditions at risk of atherosclerosis. Sampling was done by the total sampling method with 86 respondents. ELISA method used to measure Lp-PLA2 concentration and the Hematology Analyzer method used to measure number and percentage of monocyte. The results showed that at the Lp-PLA2 concentration has a significant correlation with number and percentage of monocyte (p = 0.028;a <0.050) with correlation coefficient 0.789 which shows the relationship is strong. The conclusion of this research is that an increase in the concentration of Lp-PLA2 correlates with an increase in number and percentage of monocyte on population with conditions at risk of atherosclerosis.
Other obstract
-
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2018/625/051901720 |
| Uncontrolled Keywords: | Aterosklerosis, Lp-PLA2, Monosit, Atherosclerosis, Lp-PLA2, Monocytes |
| Subjects: | 600 Technology (Applied sciences) > 616 Diseases > 616.1 Diseases of cardiovascular system > 616.13 Diseases of blood vessels > 616.136 Arteriosclerosis |
| Divisions: | Fakultas Kedokteran > Pendidikan Dokter |
| Depositing User: | Nur Cholis |
| Date Deposited: | 21 May 2020 02:56 |
| Last Modified: | 03 Jan 2023 06:56 |
| URI: | http://repository.ub.ac.id/id/eprint/168015 |
![[thumbnail of MASA EMBARGO]](http://repository.ub.ac.id/style/images/fileicons/text.png) |
Text (MASA EMBARGO)
Dinesh Vijayadas.pdf Restricted to Registered users only until 31 December 2075. Download (28MB) |
Actions (login required)
 |
View Item |