Setyoningrum, Tiara Widyasworo (2018) Analisis Korelasi Kadar LipoproteinAssociated Phospholipase A2 (Lp-PLA2) dengan Low Density Lipoprotein (LDL) pada Populasi Risiko Aterosklerosis Berdasarkan Kategori Framingham. Sarjana thesis, Universitas Brawijaya.
Abstract
Perkembangan penyakit vaskular karena aterosklerosis selalu dikaitkan dengan lipid dan disertai peradangan vaskular. Terdapat enzim Lp-PLA2 yang dilaporkan menjadi biomarker pada aterosklerosis. Lp-PLA2 diproduksi oleh makrofag pada pembuluh aterosklerotik dan berikatan sebagai kompleks dengan LDL. Lp-PLA2 berhubungan positif dengan tingkat keparahan aterosklerosis karena dua substrat yang dihasilkan, yaitu Lyso-PC dan oxNEFAs. Penelitian ini bertujuan untuk menganalisis korelasi antara kadar Lp-PLA2 dengan LDL pada populasi risiko aterosklerosis berdasarkan katergori Framingham. Penelitian ini menggunakan metode deskriptif analisis korelasi dengan 154 subjek risiko aterosklerosis yang dikelompokkan menjadi kelompok low, intermediate, dan high risk berdasarkan kategori Framingham. Sampel darah vena subjek diambil untuk diukur kadar Lp-PLA2 dan LDL menggunakan metode ELISA dan spektrofotometri. Setiap kelompok dilakukan analisis uji normalitas dan uji korelasi antar variabel. Hasil penelitian menunjukkan rata-rata kadar Lp-PLA2 kelompok low risk 0,10156 ± 0,00948 ng/ml, intermediete risk 0,09937 ± 0,00841 ng/ml, dan high risk 0,09488 ± 0,00945 ng/ml. Rata-rata kadar LDL kelompok low risk 125,15 ± 37,44 mg/dl, intermediete risk 127,92 ± 36,56 mg/dl, dan high risk 120,36 ± 86,56 mg/dl. Korelasi antara kadar Lp-PLA2 dengan LDL tidak signifikan (p>0,05) dan lemah di kelompok low risk (r=0,120), intermediate risk (r=0,201), dan high risk (r=0,161). Dapat disimpulkan, kadar Lp-PLA2 dan LDL pada populasi risiko aterosklerosis pada penelitian ini tidak berkorelasi signifikan.
English Abstract
The development of vascular disease due to atherosclerosis has been associated with lipids and accompanied by vascular inflammation. There is an Lp-PLA2 enzyme that is reported to be a biomarker in atherosclerosis. Lp-PLA2 is produced by macrophages in atherosclerotic vessels and binds as complexes with LDL. Lp-PLA2 is positively related to the severity of atherosclerosis because of two substrate produced, namely Lyso-PC and oxNEFAs. This study aims to analyze the correlation between Lp-PLA2 levels and LDL in the atherosclerotic risk population based on the Framingham category. This study used a descriptive method of correlation analysis with 154 atherosclerosis risk subjects grouped into low, intermediate and high risk groups based on the Framingham category. Subject vein blood samples were taken to measure Lp-PLA2 and LDL levels using ELISA and spectrophotometry methods. Each group carried out a normality test analysis and a correlation test between variables. The results showed that the average level of Lp-PLA2 in the low risk group was 0.10156 ± 0.00948 ng / ml, intermediete risk 0.09937 ± 0.00841 ng / ml, and high risk 0.09488 ± 0.00945 ng / ml . The average level of low risk LDL group 125.15 ± 37.44 mg / dl, intermediete risk 127.92 ± 36.56 mg / dl, and high risk 120.36 ± 86.56 mg / dl. The correlation between Lp-PLA2 and LDL levels was not significant (p> 0.05) and weak in the low risk group (r = 0.120), intermediate risk (r = 0.201), and high risk (r = 0.161). It can be concluded, the levels of Lp-PLA2 and LDL in the population at risk of atherosclerosis in this study did not correlate significantly
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2018/600/051901172 |
| Uncontrolled Keywords: | Aterosklerosis, LDL, Lp-PLA2, Framingham Risk Score, |
| Subjects: | 600 Technology (Applied sciences) > 616 Diseases > 616.1 Diseases of cardiovascular system > 616.13 Diseases of blood vessels > 616.136 Arteriosclerosis |
| Divisions: | Fakultas Kedokteran > Pendidikan Dokter |
| Depositing User: | Nur Cholis |
| Date Deposited: | 21 May 2020 00:29 |
| Last Modified: | 21 Oct 2021 04:26 |
| URI: | http://repository.ub.ac.id/id/eprint/167980 |
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