Putri, Dana Paramitha (2018) Analisis Korelasi Ekspresi Lipoprotein-Associated Phospholipase A2 (Lp-Pla2) Dengan Kadar Adiponectin Pada Populasi Risiko Aterosklerosis Berdasarkan Kategori Framingham. Sarjana thesis, Universitas Brawijaya.
Abstract
Tujuan: Penelitian ini bertujuan untuk mengetahui korelasi ekspresi lipoproteinassociated phospholipase A2 (LP-PLA2) dengan kadar adiponectin pada populasi risiko aterosklerosis berdasarkan kategori Framingham. Metode: Penelitian analitik korelasional menggunakan sampel darah vena manusia yang diambil pada populasi risiko dengan teknik total sampling sebanyak 150 sampel. Kelompok risiko dianalisis menggunakan Framingham Risk Score dan dikelompokkan menjadi kelompok low risk, intermediate risk, dan high risk. Sampel darah vena diukur menggunakan metode ELISA dengan parameter LpPLA2 dan adiponectin. Analisis data Lp-PLA2 dengan adiponectin tiap kelompok dilakukan dengan uji normalitas Kolmogorov-Smirnov dan Shapiro-Wilk Test, oneway ANOVA, uji Post Hoc Least Significance Difference, dan analisa untuk mengetahui hubungan antar variabel dengan uji Pearson. Hasil: Terdapat korelasi berbanding terbalik cukup kuat yang signifikan antara konsentrasi LpPLA2 dengan kadar adiponectin (sig <0.05) dengan koefisien korelasi 0.407, 0.420, dan 0.407 bertanda negatif untuk kelompok low risk, intermediate risk, dan high risk. Kesimpulan: Terdapat korelasi yang berbanding terbalik secara signifikan antara ekspresi Lp-PLA2 dengan kadar adiponectin bila berdasarkan pada kelompok risiko dari kategori Framingham Risk Score (low risk, intermediate risk, dan high risk).
English Abstract
Objective: To determine the correlation of lipoprotein-associated phospholipase A2 (Lp-PLA2) concentration and adiponectin level in the atherosclerosis risk population based on the Framingham Category. Method: The study used correlational analysis method. Venous blood sample was taken from 150 individuals in the risk population with total sampling technique. Atherosclerosis risk group was analyzed using Framingham Risk Score and categorized in 3 groups; low risk, intermediate risk, and high risk. Blood sample was measured by ELISA method with Lp-PLA2 and adiponectin as parameters. Analysis of Lp PLA2 and adiponectin data in every group was done using Kolmogorov-Smirnov and Shapiro-Wilk normality test, one-way ANOVA, Post Hoc Least Significance Difference test, and Pearson test for correlation analysis between the two groups. Results: Lp-PLA2 concentrations have significant inverse correlation with adiponectin level (sig <0.05) with negative correlation coefficient on value of 0.407, 0.420, and 0.407 for low risk, intermediate risk, and high risk group. Conclusion: There was a negative correlation between Lp-PLA2 concentrations and adiponectin levels in the atherosclerosis risk population based on each of the Framingham categories (low risk, intermediate risk, and high risk).
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2018/529/051900991 |
| Uncontrolled Keywords: | Aterosklerosis, Lp-PLA2, Adiponectin, Atherosclerosis, Lp-PLA2, Adiponectin |
| Subjects: | 600 Technology (Applied sciences) > 616 Diseases > 616.1 Diseases of cardiovascular system > 616.13 Diseases of blood vessels > 616.136 Arteriosclerosis |
| Divisions: | Fakultas Kedokteran > Pendidikan Dokter |
| Depositing User: | Nur Cholis |
| Date Deposited: | 05 May 2020 18:05 |
| Last Modified: | 09 Mar 2023 00:36 |
| URI: | http://repository.ub.ac.id/id/eprint/167582 |
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