Pratiwi,, Pinandita Annisa (2018) Analisis Korelasi Ekspresi Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) dengan Hypoxia Inducible Factor-1α pada Populasi Risiko Aterosklerosis berdasarkan Kategori Framingham. Sarjana thesis, Universitas Brawijaya.
Abstract
Tujuan: Mengetahui korelasi ekspresi Lp-PLA2 dengan HIF-1α pada populasi risiko aterosklerosis berdasarkan kategori Framingham. Metode: Penelitian analitik korelasional menggunakan teknik total sampling pada responden sebanyak 160 orang. Responden dianalisis faktor risikonya menggunakan Framingham risk score, kemudian dikelompokkan menjadi kelompok risiko low, intermediate, dan high. Dilakukan pengambilan sampel darah vena yang diukur menggunakan metode ELISA dengan parameter Lp-PLA2 dan HIF-1α. Analisis data dilakukan uji normalitas, homogenitas, One Way ANOVA, Post Hoc: Tukey HSD dan korelasi Pearson. Hasil: Terdapat korelasi kuat yang signifikan antara ekspresi Lp-PLA2 dan HIF-1α dengan sig<0,01 baik pada kelompok risiko low (r=0,529), intermediate (r=0,512), dan high (r=0,715). Kesimpulan: Peningkatan ekspresi Lp-PLA2 berkolerasi dengan peningkatan ekspresi HIF-1α pada kondisi aterosklerosis berdasarkan kriteria Framingham
English Abstract
Objective: To determine the correlation between expression of Lp-PLA2 and HIF-1α in atherosclerosis risk population based on the Framingham Category. Method: The study used correlational analysis method with total sampling technique in 160 individuals in the risk population. Atherosclerosis risk group was analyzed using Framingham risk score and categorized into: low, intermediate, and high risk groups. Venous blood samples taken from respondents were measured using the ELISA method with Lp-PLA2 and HIF-1α as parameters. Statistical data analysis was done using normality test, homogeneity test, one-way ANOVA, Post Hoc: Tukey HSD and Pearson correlation. Results: Lp-PLA2 expression were significant correlated with HIF-1α with p=0,000 (p sig<0,001) with coefficient correlation in low risk group (r=0,529), intermediate risk group (r=0,512), and high risk group (r=0,715). Conclusion: Increased Lp-PLA2 expression were correlated with increased HIF-1α expression in atherosclerosis condition based on Framingham category
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2018/551/051901013 |
| Uncontrolled Keywords: | Aterosklerosis, kategori Framingham, Lp-PLA2, HIF-1α, Atherosclerosis, Framingham category, Lp-PLA2, HIF-1α |
| Subjects: | 600 Technology (Applied sciences) > 616 Diseases > 616.1 Diseases of cardiovascular system > 616.13 Diseases of blood vessels > 616.136 Arteriosclerosis > 616.136 07 Arteriosclerosis--Pathogenesis > 616.136 075 61 Arteriosclerosis--Blood--Analysis |
| Divisions: | Fakultas Kedokteran > Pendidikan Dokter |
| Depositing User: | Nur Cholis |
| Date Deposited: | 13 May 2020 06:51 |
| Last Modified: | 21 Oct 2021 03:20 |
| URI: | http://repository.ub.ac.id/id/eprint/167540 |
Preview |
Text
Pinandita Annisa Pratiwi.pdf Download (5MB) | Preview |
Actions (login required)
 |
View Item |