Wahono, TitisTunjungDamanti (2014) Hubungan Persentase Lemak Tubuh (% Body Fat) dengan Kadar Vitamin D pada Pasien Systemic Lupus Erythematosus (SLE) di RSUD dr. Saiful Anwar Malang. Sarjana thesis, Universitas Brawijaya.
Abstract
Vitamin D diketahui dapat berpengaruh terhadap sistem imun dan dapat mencegah autoimun. Total body fat merupakan salah satu variabel yang mempengaruhi level serum calcidiol dengan peningkatan adiposa yang dihubungkan dengan penurunan level serum 25(OH)D. Penelitian ini bertujuan untuk mengetahui hubungan persentase lemak tubuh (% body fat) dengan kadar vitamin D pada pasien Systemic Lupus Erythematosus. Penelitian ini merupakan studi observasional dengan menggunakan metode cross sectional yang dilakukan pada 35 pasien SLE wanita di Poliklinik Rhematologi RSUD dr. Saiful Anwar Malang dengan usia produktif dan belum menopouse. Serum vitamin D (25(OH)D) dianalisa menggunakan metode ELISA. Data persentase lemak tubuh (% body fat) diukur dengan metode Bioelectrical Impedance Analyzer (BIA), dengan alat OMRON Body Fat Analyzer model HBF-306C. Hubungan antara persentase lemak tubuh (% body fat) dengan kadar vitamin D pada pasien SLE diuji dengan uji Pearson. Hasil penelitian sebanyak 60,0% pasien SLE memiliki kadar vitamin D dibawah normal/insufisiensi, dengan rerata ± SD kadar vitamin D 21,73 ± 7,59 ng/ml. Sedangkan pengukuran persentase lemak tubuh (% body fat) didapatkan data rerata ± SD pasien SLE 28,26 ± 8,19%, dengan distribusi kategori rendah 20,0%, normal 45,7%, tinggi 25,7%, dan sangat tinggi 8.6%. Terdapat hubungan yang signifikan antara persentase lemak tubuh (% body fat) dengan kadar vitamin D pada pasien Systemic Lupus Erythematosus (p=0,015), dengan kekuatan korelasi (r=-0,409) sedang. Kesimpulan dari penelitian ini adalah terdapat hubungan yang signifikan antara persentase lemak tubuh (% body fat) dengan kadar vitamin D pada pasien Systemic Lupus Erythematosus, dengan korelasi negatif yaitu semakin tinggi nilai persentase lemak tubuh (% body fat) maka kadar vitamin D semakin rendah. Rendahnya kadar vitamin D pada pasien SLE disebabkan dikarenakan serum 25(OH)D lebih banyak tersimpan di dalam fat mass daripada yang terdistribusi.
English Abstract
Vitamin D is known to affect immune system and prevent autoimmune. Total body fat is one of the variables that affect the level of serum calcidiol with increased adipose associated with decreased levels of serum 25(OH)D. The objective of our study was to prove the relation of body fat percentage (% body fat) and vitamin D levels in Systemic Lupus Erythematosus patients. This observational study used cross-sectional methods performed in 35 female SLE patients at the clinic Rhematologi dr. Saiful Anwar Hospital Malang, productive age and not menopause. Serum vitamin D (25(OH)D) were analyzed using ELISA method. Data body fat percentage (% body fat) was measured by bioelectrical impedance method Analyzer (BIA), measuring instrument used OMRON Body Fat Analyzer HBF-306C models. The relation between body fat percentage (% body fat) with vitamin D level in SLE patients were analyzed with the Pearson test. The results of this study 60,0% of SLE patients had vitamin D level below normal/insufficiency, mean ± SD vitamin D level were 21,73 ± 7,59 ng/ml. Measurement of body fat percentage (% body fat) mean ± SD SLE patients 28,26 ± 8,19%, 20,0 % distribution of the low category, 45,7% normal, 25,7% high, and very high 8.6%. There was significant correlation between of body fat percentage (% body fat) and vitamin D level in Systemic Lupus Erythematosus patients (p=0,015), with medium strength of the correlation (r=-0,409). The conclusion of this study there was significant correlation between body fat percentage (% body fat) with vitamin D level in Systemic Lupus Erythematosus patients with a negative correlation that the higher percentage of body fat (% body fat) then the lower the vitamin D levels. Low levels of vitamin D in SLE patients due to serum 25(OH)D more stored in fat mass rather than distributed.
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2014/452/051403574 |
| Subjects: | 600 Technology (Applied sciences) > 613 Personal health and safety > 613.2 Dietetics |
| Divisions: | Fakultas Kedokteran > Ilmu Gizi |
| Depositing User: | Budi Wahyono Wahyono |
| Date Deposited: | 30 Jun 2014 10:56 |
| Last Modified: | 21 Oct 2021 17:50 |
| URI: | http://repository.ub.ac.id/id/eprint/124448 |
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