Putra, FreddySagita (2014) Efektivitas Ekstrak Etanol Ketela Rambat (Ipomoea batatas) Dalam Menurunkan Klasifikasi Nefritis Lupus Pada Mencit Model Lupus Eritematosus Sistemik (LES). Sarjana thesis, Universitas Brawijaya.
Abstract
Lupus eritematosus sistemik (LES) adalah penyakit autoimun multisistem yang menyerang berbagai organ dan sistem, diantaranya: sendi, kulit, otak, jantung, paru- paru, pembuluh darah, dan ginjal. Lupus nefritis (LN) merupakan salah satu bentuk komplikasi yang sering dan berbahaya. Ketela rambat kaya vitamin A yang merupakan senyawa antioksidan sehingga diharapkan dapat menghambat progresifitas kerusakan dan meregenerasi sel ginjal. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak etanol ketela rambat pada ginjal mencit model LES, dilihat dari gambaran histologi dengan indikator staging Nefritis Lupus. Penelitian eksperimental laboratoris ini menggunakan 20 ekor mencit yang dikelompokkan menjadi 4 kelompok perlakuan Kontrol dan 3 kelompok perlakuan dengan dosis 175 mg/KgBB, 350 mg/KgBB dan 700 mg/KgBB. Setelah 5 bulan perlakuan, dilakukan pembedahan, dilakukan pengamatan pada sel ginjal dan dilakukan analisis data. Hasil Uji Kruskall Wallis menunjukkan hasil yang signifikan sig. = 0.002 (p<0.05). Kesimpulan penelitian ini, pemberian ekstrak ethanol ketela rambat mampu menurunkan staging Nefritis Lupus
English Abstract
Sistemic Lupus Erythematosus is an autoimmune disease that attacks various organs and systems, joints, skins, brains, heart, lungs, blood vessels, and kidneys. Lupus Nephritis (LN) is one of the most often and dangerous complication of SLE. Purple sweet potatoes rich of Vitamin A, an antioxidant agents, so theoretically, it can inhibit the damage progressivity and regenerates the kidneys cells. This study aims to know the effect of purple sweet potatoes administration in kidneys rats model of SLE, seen from histology in Lupus Nephritis staging criterian. This true experimental study used 20 rats, divide in 5 groups, Positive Control, Negative Control, and 3 groups given Ipomoea batatas extracts in 3 different doses, 175 mg/KgBB, 350 mg/KgBB and 700 mg/KgBB. After 5 months, the rats were secrificed, the kidneys were isolated, then made preparations of kidneys tissue. The statistical result, Kruskall Wallis test showed significant differences, sig. = 0.002 (p<0.05). The conclusion of this study is Ipomoea batatas ethanol extract can reduce the stage of Lupus Nephritis in rats model of SLE.
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2014/434/051403527 |
| Subjects: | 600 Technology (Applied sciences) > 610 Medicine and health > 610.7 Education, research, nursing, services of allied health personnel |
| Divisions: | Fakultas Kedokteran > Pendidikan Dokter |
| Depositing User: | Budi Wahyono Wahyono |
| Date Deposited: | 27 Jun 2014 10:14 |
| Last Modified: | 21 Oct 2021 16:25 |
| URI: | http://repository.ub.ac.id/id/eprint/124428 |
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