Ayuningtyas, ImaliaNurrachma (2013) Pembuatan Dan Optimasi Elektroda Selektif Ion Merkuri Berbasis Kitosan Untuk Mengukur Kadar Merkuri Dalam Sediaan Kosmetik. Sarjana thesis, Universitas Brawijaya.
Abstract
Kandungan logam merkuri dalam kosmetik sangat berbahaya bagi kesehatan. Merkuri ditambahkan ke dalam kosmetik supaya kulit tampak lebih cerah. Pengembangan metoda sensor potensiometri menggunakan elektroda selektif ion (ESI) merkuri tipe kawat terlapis diharapkan mampu mendeteksi ion logam merkuri. Tujuan penelitian ini adalah membuat ESI ion merkuri (Hg2+) tipe kawat terlapis bermembran kitosan yang memiliki karakter optimum untuk analisis. ESI dibuat dari kawat platina (Pt) yang dilapisi membran yang terbuat dari campuran bahan aktif kitosan, polimer polivinylchloride (PVC), dan pemlastis dioktilphtalat (DOP) dalam pelarut tetrahidrofuran (THF) dengan perbandingan 1:3 (b/v). Optimasi ESI Hg2+ yang dilakukan meliputi: optimasi perbandingan komposisi membran dan lama waktu perendaman membran dalam larutan HgCl2 0,25 M pada waktu 10; 20; 30; 40; 50; dan 60 menit, serta karakterisasi sifat dasar ESI Hg2+ yang meliputi: faktor Nernst, rentang konsentrasi linier, batas deteksi, dan waktu respon. Hasil penelitian menunjukkan perbandingan komposisi optimum membran ESI Hg2+ adalah 3% kitosan : 39% PVC : 58% DOP dengan waktu perendaman optimum selama 40 menit. ESI Hg2+ yang dibuat bersifat Nernstian dengan nilai faktor Nernst 29,35 mV/dekade konsentrasi dan R2 = 0,923; rentang konsentrasi linier 1x10-1 – 1x10-7 M; batas deteksi 7,99x10-8 M atau 0,022 ppm; dan waktu respon 200 detik
English Abstract
Content of mercury metal in cosmetics is very harmful for human health. Mercury is added to cosmetics for skin looks brighter. Development potentiometric sensor method using a coated wire mercury ion selective electrode (mercury CWE) expected to be able to detect mercury ions. The purpose of this study is to develop mercury ion CWE base on membranous chitosan which has optimum character for analysis. Mercury (Hg2+) CWE is made of platinum wire (Pt) coated by membranes are made from a mixture of the active ingredient chitosan, polyvinylchloride (PVC) polymer, and dioctylphtalate plasticizer (DOP) at various compositions were dissolved in tetrahydrofuran (THF) solvent with a ratio of 1:3 (w/v). The optimized Hg2+ CWE was done included: the effects of membrane composition, the soaking time in mercury chloride 0.25 M solution at time of 10; 20; 30; 40; 50; and 60 minutes, and the basic characteristics of Hg2+ CWE included: Nernst factor, range of linear concentration, detection limits, and response time. The result of this study showed that optimum composition of Hg2+ CWE membrane consist of (% weight) chitosan : PVC : DOP = 3 : 39 : 58, soaking time was 40 minutes, has a Nernstian character (Nernst factor value was 29,35 mV/decade) and R2 = 0,923. The linear concentration range from 1x10-1 – 1x10-7 M. The detection limits concentration was 7,99x10-8 M or 0,022 ppm and the response time of 200 second.
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2013/542/051307473 |
| Subjects: | 600 Technology (Applied sciences) > 615 Pharmacology and therapeutics > 615.1 Drugs (materia medica) |
| Divisions: | Fakultas Kedokteran > Farmasi |
| Depositing User: | Hasbi |
| Date Deposited: | 17 Oct 2013 10:22 |
| Last Modified: | 20 Oct 2021 02:08 |
| URI: | http://repository.ub.ac.id/id/eprint/123830 |
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