Asadullah, M (2018) Potensi Terapi Rimpang Pletekan (Ruellia Tuberosa L.) Terhadap Kadar Mda (Malondialdehyde), Insulin, Aktivitas Sod (Superoxide Dismutase) Dan Gambaran Histopalogi Pada Organ Pankreas Tikus Diabetes Hasil Induksi Multiple Low Dose Streptozoticin (Mld-Stz). Magister thesis, Universitas Brawijaya.
Abstract
Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak akar pletekan terhadap kadar MDA (malondialdehyde), insulin, aktivitas SOD (Superoxide Dismutase) dan gambaran histopalogi pada organ pankreas. Pada penelitian ini hewan coba yang digunakan adalah tikus putih strain wistar dengan berat rata-rata 180 gram yang di induksikan dengan Multiple Low Dose Streptozoticin (MLD-STZ) dengan dosis 20 mg/kgBB selama 5 hari berturut-turut. Pengukuran kadar glukosa diukur dengan glucometer digital dan dinyatakan DM apabila kadar glukosa mencapai 200 mg/dL. Ekstrak akar pletekan diberikan dengan dosis 250 mg/kgBB dan dosis 500 mg/kgBB selama 21 hari berturut-turut. Kandungan yang diidentifikasi positif golongan triterpenoid menggunakan uji fitokimia. Hasil penelitian menunjukkan bahwa pemberian terapi ekstrak akar pletekan dengan dosis 250 mg/kgBB dan 500 mg/kgBB pada tikus yang diinduksi MLD-STZ menunjukkan penurunan kadar glukosa darah berturut-turut sebesar 52.95% dan 64.24%. penurunan kadar MDA sebesar 27.27% dan 67.53%. peningkatan aktivitas SOD sebesar 77.85% dan 87.65% dan peningkatan kadar insulin sebesar 13.25% dan 22.69% serta perbaikan kerusakan jaringan pankreas mendekati normal pada dosis 500 mg/kgBB.
English Abstract
This study purpose to determine the effect of R. tuberosa root on MDA (malondialdehyde), insulin, SOD (Superoxide Dismutase) and histopalogical features in pancreatic organs. In this study, the trial used was white rat strain wistar with average weight of 180 gram which was induced with Multiple Low Dose Streptozoticin (MLD-STZ) with dose 20 mg/kgBB for 5 days in a row. Measurement of glucose levels measured with a digital glucometer and expressed DM when glucose levels reach 200 mg/dL. R. tuberosa root extract was given at a dose of 250 mg/kgBW and a dose of 500 mg/kgBB for 21 consecutive days. The content is positively identified by triterpenoid group using phytochemical test. The results showed that the treatment of R. tuberosa root extract at doses of 250 mg/kgBW and 500 mg/kgBW in MLD-STZ induced rats showed a reduce glucose levels of 52.95% and 64.24%. reduce MDA levels by 27.27% and 67.53%. increased SOD activity by 77.85% and 87.65% and increased insulin levels by 13.25% and 22.69% and repair of pancreatic tissue damage near normal at dose 500 mg / kgBB.
| Item Type: | Thesis (Magister) |
|---|---|
| Identification Number: | TES/615.323 95/ASA/p/2018/041802366 |
| Uncontrolled Keywords: | ACANTHACEAE, MALONDIALDEHYDE, INSULIN, SUPEROXIDE DISMUTASE, PANCREAS, DIABETES |
| Subjects: | 600 Technology (Applied sciences) > 615 Pharmacology and therapeutics > 615.3 Organics drugs > 615.32 Drugs derived from plants and mikroorganisms > 615.323 95 Drugs derived from spesific plant (Scrophulariales) |
| Divisions: | S2/S3 > Magister Kimia, Fakultas MIPA |
| Depositing User: | Nur Cholis |
| Date Deposited: | 24 Apr 2018 07:04 |
| Last Modified: | 21 Oct 2021 07:29 |
| URI: | http://repository.ub.ac.id/id/eprint/9848 |
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4. BAB IV.pdf Download (80kB) |
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00. Cover.pdf Download (63kB) |
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1. BAB I.pdf Download (47kB) |
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7. DAFTAR PUSTAKA.pdf Download (88kB) |
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8.1 Data MDA.pdf Download (59kB) |
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8.2 Glukosa dan MDA.pdf Download (70kB) |
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8.3 Data SOD Asadullah.pdf Download (67kB) |
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8.4 Elisa InsulinAsadullah.pdf Download (64kB) |
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BAGIAN DEPAN.pdf Download (164kB) |
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