Komala, Anton (2017) Gambaran Kadar Interleukin-18 (Il-18) Serum Pada Pasien Sirosis Hati Dan Hubungannya Dengan Ensefalopati Hepatik. Magister thesis, Universitas Brawijaya.
Abstract
Latar Belakang: Proses inflamasi memiliki peran penting dalam patofisiologi terjadinya ensefalopati hepatik (EH) pada sirosis hati. IL-18 merupakan mediator kunci yang berperan dalam proses neuroinflamasi yang dapat menimbulkan gejala EH. Tujuan: Mengetahui gambaran kadar IL-18 serum pada pasien sirosis hati dan menilai hubungan kadar IL-18 serum dengan EH. Metode: Sebanyak 52 subjek (32 pasien sirosis hati dan 20 subjek sehat sebagai kontrol) terlibat dalam penelitian ini. 32 pasien sirosis hati akan dinilai derajat EH berdasarkan kriteria West-Haven. Seluruh subjek penelitian diperiksa kadar IL-18 serum dengan metode ELISA. Dilakukan analisa perbandingan antara kadar IL-18 serum pasien sirosis hati dengan subjek sehat, analisa korelasi antara kadar IL-18 serum dengan derajat EH, dan analisa perbandingan kadar serum IL-18 antara derajat EH. Hasil: Rata-rata kadar IL-18 serum pada kelompok sirosis hati sebesar 688.5 ± 674.3 pg/ml, dan kelompok kontrol sehat sebesar 163.9 ± 100 pg/ml dengan nilai p sebesar 0.01 (p<0.05). Hasil analisa korelasi antara kadar IL-18 serum dengan EH didapatkan koefisien korelasi sebesar 0.85 dengan nilai p sebesar 0.00 (p < 0.05). Kadar serum IL-18 kelompok EH covert dan EH overt lebih tinggi dan berbeda bermakna dibandingkan dengan tanpa EH (p < 0.05) Kesimpulan: Kadar IL-18 serum pada pasien sirosis hati lebih tinggi bila dibandingkan dengan subjek sehat, terdapat hubungan positif antara kadar IL-18 serum dengan EH pada pasien sirosis hati, dan kadar IL-18 serum pada pasien sirosis hati dengan EH lebih tinggi dibandingkan dengan tanpa EH.
English Abstract
Background: The inflammatory process has an important role in the pathophysiology of hepatic encephalopathy (HE) in liver cirrhosis. IL-18 is a key mediator who plays a role in neuroinflamation processes that can lead to symptoms of HE. Objective: To determine serum IL-18 levels in liver cirrhosis patients and to assess the association of serum IL-18 levels with HE. Methods: A total of 52 subjects (32 patients with liver cirrhosis and 20 healthy controls) were enrolled in this study. 32 patients with liver cirrhosis will be assessed for HE based on West-Haven criteria. All subjects were examined for serum IL-18 levels which is measured by ELISA method. We performed a comparative analysis between serum IL-18 levels of liver cirrhosis patients and healthy controls, a correlation analysis between serum IL-18 levels and HE, and a comparative analysis of serum IL-18 levels among degrees of HE. Results: Mean serum IL-18 levels in the liver cirrhosis group were 688.5 ± 674.3 pg/ml, and in the healthy controls group were 163.9 ± 100 pg/ml with p value = 0.01 (p <0.05). There was a significant correlation between IL-18 and HE (r = 0.85, p = 0.00). Serum IL-18 levels in covert and overt HE groups were significantly higher than those without HE (p <0.05). Conclusions: Serum IL-18 levels were significantly higher in liver cirrhosis patients than in healthy controls. There was a positive correlation between IL-18 and HE. Serum IL-18 levels in liver cirrhosis patients with HE were significantly higher than those without HE.
| Item Type: | Thesis (Magister) |
|---|---|
| Identification Number: | TES/616.362 4/KOM/g/2017/041801071 |
| Uncontrolled Keywords: | LIVER - CIRRHOSIS, INTERKUKIN - 18, HEPATIC ENCEPHALOPATHY |
| Subjects: | 600 Technology (Applied sciences) > 616 Diseases > 616.3 Diseases of digestive system > 616.36 Diseases of biliary tract and liver > 616.362 Diseases of liver /Liver--Diseases |
| Divisions: | S2/S3 > Magister Ilmu Biomedis, Fakultas Kedokteran |
| Depositing User: | Nur Cholis |
| Date Deposited: | 26 Mar 2018 06:27 |
| Last Modified: | 21 Oct 2021 01:07 |
| URI: | http://repository.ub.ac.id/id/eprint/8949 |
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