Kamaiswara, Anta Seri (2017) Pengaruh Jus Buah Pepaya (Carica Papaya L.) Terhadap Jumlah Fibroblas Pada Penyembuhan Luka Post Gingivektomi Tikus Wistar Jantan (Rattus Norvegicus). Sarjana thesis, Universitas Brawijaya.
Abstract
Gingivektomi adalah salah satu bedah periodontal dengan mengeksisi jaringan gingiva untuk menciptakan bentuk anatomis sehingga mengakibatkan adanya luka terbuka pada gingival. Buah pepaya (Carica papaya L) memiliki kandungan flavonoid, saponin dan vitamin C yang dapat membantu meningkatkan fibroblas sehingga mempercepat proses penyembuhan luka. Tujuan penelitian ini adalah untuk mengetahui pengaruh buah pepaya (Carica papaya L.) terhadap jumlah sel fibroblas pada penyembuhan luka pasca gingivektomi pada Rattus novergicus. Penelitian ini menggunakan metode true eksperimental yang dikerjakan di laboratorium secara in-vivo dengan menggunakan rancangan percobaan Randomized Group Post Test Only Design. Konsentrasi jus yang digunakan adalah 60%, 80%, 100%, kontrol positif tanpa pemberian jus buah pepaya. Pada konsentrasi 60% didapatkan jumlah sel fibroblas paling sedikit sementara pada konsentrasi 100% didapatkan jumlah sel fibroblaspaling banyak. Analisis data menggunakan One-way ANOVA menunjukkan adanya perbedaan yang signifikan pada perubahan konsentrasi jus buah pepaya terhadap jumlah sel fibroblas (p<0,05). Uji korelasi Pearson menunjukkan adanya hubungan yang kuat yang menunjukkan semakin meningkatnya konsentrasi maka jumlah sel fibroblas semakin meningkat atau semakin efektif. Berdasarkan penelitian ini, dapat disimpulkan bahwa jus buah pepaya (Carica papaya L.) efektif dalam meningkatkan jumlah sel fibroblas pada penyembuhan luka.
English Abstract
Gingivectomy is one of periodontal surgery by expelling the gingival tissue to create an anatomical shape resulting in an open wound on the gingiva. Gingival enlargement is one of the common periodontal disease. Papaya (Carica papaya L) contains flavonoids, saponin and vitamin C which can help improve fibroblast, thus speeding up the wound healing process. The purpose of this study was to determine the effect of papaya fruit (Carica papaya L.) to fibroblast cells count in healing process after gingivectomy on a male Rattus norvegicus. This study used true experimental method on laboratory in-vivo with Randomized Group Post Test Only Design. The extract concentrations that were used were 60%, 80%, 100% and positive control without papaya juice. At concentration of 60% weobtained the minimum numbers of fibroblast cells, while at concentration of 100% weobtained the maximum numbers of fibroblast cells. Data analysis using One-way ANOVA showed a significant difference in the change in concentration of papaya juice against the number of fibroblast cells (p <0.05). Pearson correlation test showed a strong relationship that shows the increasing of concentration leads to increased fibroblast cells. Based on this study, it can be concluded that the papaya (Carica papaya L.) juice is effective on increasing the number of fibroblast cells count in healing process.
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FKG/2017/88/051711786 |
| Uncontrolled Keywords: | Gingivektomi, Fibroblas, Buah Pepaya (Carica papaya L.), Gingivectomy, Fibroblast, Papayafruit (Carica papaya L.). |
| Subjects: | 600 Technology (Applied sciences) > 617 Surgery, regional medicine, dentistry, ophthalmology, otology, audiology > 617.6 Dentistry > 617.63 Dental diseases > 617.632 Diseases of gums and tooth sockets / Periodontics > 617.632 06 Periodontics--Treatment / Gingivitis--Treatment |
| Divisions: | Fakultas Kedokteran Gigi > Kedokteran Gigi |
| Depositing User: | Nur Cholis |
| Date Deposited: | 20 Dec 2017 08:07 |
| Last Modified: | 23 Sep 2020 05:16 |
| URI: | http://repository.ub.ac.id/id/eprint/7313 |
![[thumbnail of BAB 1.pdf]](http://repository.ub.ac.id/style/images/fileicons/text.png) |
Text
BAB 1.pdf Restricted to Repository staff only Download (347kB) |
|
Text
BAB 2.pdf Restricted to Repository staff only Download (672kB) |
|
Text
BAB 3.pdf Restricted to Repository staff only Download (568kB) |
|
Text
BAB 4.pdf Restricted to Repository staff only Download (629kB) |
|
Text
BAB 5.pdf Restricted to Repository staff only Download (1MB) |
Actions (login required)
 |
View Item |