Rachmada, Giriza Sefiardi (2017) Pengaruh Terapi Ekstrak Etanol Daun Kersen (Muntingia calabura) Terhadap Aktivitas SOD Dan Kadar Enzim SGPT-SgOt Pada Serum Tikus (Rattusnorvegicus) Model Fibrosis Hepar Pasca Induksi Ccl4. Sarjana thesis, Universitas Brawijaya.
Abstract
Fibrosis hepar merupakan penyakit hati kronik dan ditandai dengan adanya akumulasi protein ECM (Ekstraceluller Matrix). Kejadian fibrosis hepar dapat disebabkan karena induksi CCl4 yang merupakan senyawa hepatotoksik. Daun kersen (Muntingia calabura) memiliki potensi sebagai antioksidan, antibakteri dan antiinflamasi. Daun kersen mengandung flavonoid yang mampu menghambat efek toksik melalui pengikatan radikal bebas dan dekomposisi peroksida lipid. Penelitian ini mempelajari pengaruh pemberian terapi ekstrak etanol daun kersen (Muntingia Calabura) terhadap aktivitas Superoksida Dismutase (SOD) dan kadar SGPT-SGOT serum tikus (Rattus norvegicus) model fibrosis hepar pasca induksi CCl4. Hewan coba tikus putih (Rattus norvegicus) dibagi menjadi empat kelompok yaitu kontrol negatif, kelompok fibrosis hepar yang diberi induksi karbon tetraklorida (CCl4), kelompok fibrosis hepar dan terapi ekstrak etanol daun kersen dengan dosis 120 mg/180 g BB, dan kelompok fibrosis hepar dan terapi ekstrak etanol daun kersen dengan dosis 360 mg/180 g BB. Data hasil pengamatan aktivitas SOD dan kadar SGPT-SGOT dianalisis dengan uji ANOVA dan dilakuan analisis lebih lanjut dengan uji BNJ (α = 0.05 %) untuk mengetahui perbedaan antar kelompok perlakuan dengan terapi yang diberikan. Hasil penelitian menunjukkan bahwa pemberian terapi ekstrak etanol daun kersen (Muntingia calabura) secara signifikan meningkatkan aktivitas SOD sebesar 27,3 % dan menurunkan kadar SGPT-SGOT masing-masing sebesar 41,85 % dan 39,62 % dengan dosis terbaik 360 mg/180 g BB. Kesimpulan dari penelitian ini menunjukkan bahwa ekstrak etanol daun kersen dapat digunakan sebagai terapi fibrosis hepar.
English Abstract
Liver fibrosis is a chronic liver disease and characterized by accumulation of ECM proteins (Extraceluller Matrix). The incidence of liver fibrosis can be caused by CCl4 induction which is hepatotoxic compound. Leaves of cherry (Muntingia calabura) can be used as an antioxidant, antibacterial and antiinflammatory. Leaves of cherry contains flavonoids that can inhibit the toxic effects by binding free radicals and lipid peroxide decomposition.This research was aimed to study the effect of ethanol extract of cherry leaves therapy (Muntingia calabura) against Superoksida Dismutase activity and levels of SGPT-SGOT serum of rats (Rattus norvegicus) hepatic fibrosis models after CCl4 induction. Rats (Rattus norvegicus) were divided into four groups: group negative control, group fibrosis of the liver by induction of carbon tetrachloride (CCl4), group fibrosis of the liver and therapy ethanol extract of leaves of cherry with a dose of 120 mg / 180 g BW, and the group fibrosis of the liver and therapy ethanol extract of leaves of cherry with a dose of 360 mg / 180 g BW. The data of SOD activity and levels of SGPT-SGOT were analyzed using ANOVA test and further analysis was done with BNJ test (α = 0.05%) to determine the differences between the group treated with therapy given. Results showed the administration of cherry (Muntingia calabura ) leaves ethanolic extract therapy was significantly increase SOD activity 27.3% and lower levels of SGPT-SGOT respectively 41.85% and 39.62% best with dose 360 mg / 180 g BB. Conclution from the research shows that the ethanol extract of leaves of cherry can be used as therapy of liver fibrosis.
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FKH/2017/76/051704888 |
| Uncontrolled Keywords: | Daun Kersen, Fibrosis Hepar, SGPT-SGOT , SOD |
| Subjects: | 600 Technology (Applied sciences) > 615 Pharmacology and therapeutics > 615.3 Organics drugs > 615.32 Drugs derived from plants and mikroorganisms > 615.323 674 Drugs derived from specific plants (sapotaceae) > 615.323 68 Drugs derived from specific plants (elaeocarpaceae) |
| Divisions: | Fakultas Kedokteran Hewan > Kedokteran Hewan |
| Depositing User: | Yusuf Dwi N. |
| Date Deposited: | 20 Jul 2017 03:50 |
| Last Modified: | 25 Nov 2020 04:54 |
| URI: | http://repository.ub.ac.id/id/eprint/423 |
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