Rizky, Putri Nurhanida (2017) Evaluation of Scutellaria baicalensis root hot water extract effects on Photobacterium damselae subsp. piscicida and Piscicola geometra of cobia (Rachycentron canadum). Magister thesis, Universitas Brawijaya.
Abstract
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English Abstract
The root of Scutellaria baicalensis has been used as a drug for antiinflammatory, antiviral, anticarcinogenic, free-radical scavenging, antioxidant and immunostimulatory effects. The root of S.baicalensis has a high content of flavonoids (over 40%) including baicalin, wogonin, wogonoside, chrysin, oroxylin-A, and skullcap flavones. The aim of this study is to analyze the antibacterial and anti-parasitic activity of S.baicalensis root by water extraction, supplemented in cobia fed and as a bath treatment. S.baicalensis root water extract supplemented in fish feed failed to reduce the number of marine leeches. However, it showed high accuracy to enhance the growth performance, feed utilization, and disease resistance against Photobacterium damselae subsp. piscicida after 30 days of feeding health cobia and 90 days with leech infestation. Cobia fed supplemented S.baicalensis root water extract also showed significant enhancement of myeloperoxidase content, peroxidase VIII content, and lysozyme activity in cobia serum. Moreover, S.baicalensis root water extract up-regulated the expression of TLR-9, IL-1β, IgM, and TNF-α in the spleen. 1% concentration of S.baicalensis root water extract supplemented in feed showed the high accuracy to enhance growth performance, innate immune system and disease resistance of cobia against bacteria infection. Bathing treatment of cobia shows the 60% mortality and detachment of the leeches (Piscicola geometra) after 72 hours exposure with 500X and 1000X dilution of S.baicalensis root water extract. Therefore, there was no significant cell damage, or lesions of the cobia gills, spleen, kidney, and liver. This study proved the use of S.baicalensis root water extract as an immunostimulant in cobia culture industry with significant efficacy, low cost, and ease of practice
| Item Type: | Thesis (Magister) |
|---|---|
| Identification Number: | TES/615.323 96/RIZ/e/2017/041709016 |
| Uncontrolled Keywords: | SCUTELLARIA, COBIA, PHOTOBACTERIUM |
| Subjects: | 600 Technology (Applied sciences) > 615 Pharmacology and therapeutics > 615.3 Organics drugs > 615.32 Drugs derived from plants and mikroorganisms > 615.323 96 Drugs derived from spesific plant (Lamiales) |
| Divisions: | S2/S3 > Magister Budidaya Perairan, Fakultas Perikanan dan Ilmu Kelautan |
| Depositing User: | Nur Cholis |
| Date Deposited: | 03 Oct 2017 07:24 |
| Last Modified: | 30 Dec 2020 14:52 |
| URI: | http://repository.ub.ac.id/id/eprint/3198 |
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