Izzati, Arina Aftritia and dr. Iin Noor Chozin, Sp.P(K) and dr. Suryanti Dwi Pratiwi, Sp.P(K) (2024) “Efek Jinten Hitam (Nigella sativa) terhadap kadar Hb dan VEGF pasien Kanker Paru yang Menjalani Kemoterapi di RSUD dr. Saiful Anwar Jawa Timur”. Magister thesis, Universitas Brawijaya.
Abstract
Latar Belakang : Studi menunjukkan efek sitotoksik ekstrak dan minyak biji jinten hitam mampu menurunkan viabilitas sel kanker paru termasuk VEGF dan meningkatkan Hb pasien kanker. Penelitian ini bertujuan membandingkan kadar Hb dan VEGF antara pasien kanker paru yang diberi kemoterapi dan jinten hitam (Nigella sativa) dengan kemoterapi sesuai standar. Metode : Pendekatan kuantitatif dengan metode Pre-post test control group Design yang melibatkan 21 pasien kanker paru di RSUD dr. Saiful Anwar Jawa Timur yang diamati selama 9 minggu antara bulan Juni hingga Oktober 2023. Kelompok kontrol adalah pasien dengan kemoterapi standar dan kelompok perlakuan dengan kemoterapi dan pemberian Jinten Hitam. Pemeriksaan kadar Hb dan VEGF dengan ELISA. Hasil : Terdapat perbedaan pre dan post setelah penelitian 9 minggu yang signifikan pada kadar Hb maupun VEGF diantara kelompok kontrol dan perlakuan dengan nilai p=0,021 dan nilai p=0,007. Namun tidak terjadi perbedaan signifikan antara delta Hb dan VEGF pre dan post perlakuan pada kelompok kontrol dan perlakuan dengan masing masing nilai p=0,224 dan p=0,754. Kesimpulan : Penambahan jinten hitam selama 9 Minggu berperan menahan penurunan nilai Hb dan menurunkan kadar VEGF pada pasien kanker yang mendapatkan kemoterapi standar.
English Abstract
Background : Studies show the cytotoxic effect of black cumin seed extract and oil can reduce the viability of lung cancer cells including VEGF and increase the Hb of cancer patients. This study aims to compare Hb and VEGF levels between lung cancer patients who were given chemotherapy and black cumin and those undergoing standard chemotherapy. Method : This study employed a quantitative approach using the pre-post test control group design method involving 21 lung cancer patients at dr. Saiful Anwar General Hospital, East Java, who were observed for 9 weeks between June and October 2023. The control group includes patients undergoing standard chemotherapy and the treatment group includes those undergoing chemotherapy with the addition of black cumin. Hb and VEGF levels were examined using ELISA. Result : There were significant pre and post differences after the 9-week study in Hb and VEGF levels between the control and treatment groups with p-value = 0.021 and p-value = 0.007. However, there was no significant difference between delta Hb and VEGF pre and post treatment in the control and treatment groups with p-value = 0.224 and p-value = 0.754. Conclusion : The addition of black cumin for 9 weeks was able to prevent a decrease in Hb levels and reduce VEGF levels in lung cancer patients with standard chemotherapy.
| Item Type: | Thesis (Magister) |
|---|---|
| Identification Number: | 0424060191 |
| Uncontrolled Keywords: | Kanker paru, Hb, VEGF, dan Nigella Sativa. |
| Divisions: | Profesi Kedokteran > Spesialis Pulmonologi dan Kedokteran Respirasi, Fakultas Kedokteran |
| Depositing User: | Unnamed user with username nova |
| Date Deposited: | 11 Mar 2025 02:06 |
| Last Modified: | 11 Mar 2025 02:06 |
| URI: | http://repository.ub.ac.id/id/eprint/238225 |
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