Irhamsyah, Muchammad Kemal and \ Dr.dr Seskoati Prayitnaningsih, Sp.M(K) and Dr. dr. Agustin Iskandar, M.Kes, Sp.PK(K). (2024) Hubungan Kadar ET-1 dengan Flux Index, Perfusi Kapiler, dan Ketebalan RNFL dari Pemeriksaan OCT pada Individu Obesitas. Magister thesis, Universitas Brawijaya.
Abstract
Untuk mengidentifikasi hubungan antara kadar endothelin-1 (ET-1) dan flux index (FI), perfusi kapiler (PK), dan ketebalan lapisan serat saraf retina (RNFL) di sekitar kepala saraf optik menggunakan Ocular Coherence Tomography Angiography (OCTA). Metode: Studi kasus kontrol prospektif ini dilakukan pada bulan Desember 2022 hingga Maret 2023 di Rumah Sakit Umum Daerah Dr. Saiful Anwar (Malang, Indonesia). Kami memasukkan 40 orang dewasa yang mengalami obesitas dan 40 orang dewasa non-obesitas yang berusia antara 25 dan 54 tahun. Pasien dengan peningkatan tekanan intraokular (TIO >21 mmHg), kelainan segmen posterior, dan penyakit penyerta (penyakit menular, diabetes melitus, dislipidemia) dikeluarkan dari penelitian. Kadar ET-1 dinilai dengan enzim immunosorbent assay (ELISA). FI, CP, dan RNFL diukur menggunakan OCTA. Uji Mann-Whitney U, uji t tidak berpasangan, dan uji peringkat Spearman dilakukan untuk menganalisis data. Hasil: Tidak terdapat perbedaan kadar ET-1 antara kelompok obesitas dan non obesitas (P = 0,216). Rata-rata FI hidung, FI inferior, FI luar, dan CP inferior lebih rendah pada kelompok obesitas dibandingkan dengan kelompok non-obesitas (P = 0,050, P = 0,010, P = 0,015, dan P = 0,017, masing-masing). Rata-rata ketebalan RNFL pada kelompok obesitas juga lebih rendah dibandingkan kelompok kontrol. Namun, perbedaan ini tidak signifikan secara statistik (p >0,102). Kesimpulan: Indeks fluks dan perfusi kapiler di sekitar kepala saraf optik dapat dianggap sebagai prediktor gangguan mikrovaskuler pada individu dengan obesitas. Tanda-tanda gangguan perfusi (diwakili oleh FI dan CP) mungkin mendahului disfungsi endotel (diwakili oleh ET-1).
English Abstract
To identify the association between endothelin-1 (ET-1) levels and flux index (FI), capillary perfusion (CP), and retinal nerve fiber layer (RNFL) thickness around the optic nerve head using optical coherence tomography angiography (OCTA). Methods: This prospective case-control study was carried out from December 2022 to March 2023 at Dr. Saiful Anwar General Hospital (Malang, Indonesia). We included 40 obese and 40 non-obese adults between 25 and 54 years of age. Patients with increased intraocular pressure (IOP >21 mmHg), posterior segment abnormalities, and comorbidities (infectious diseases, diabetes mellitus, dyslipidemia) were excluded. ET-1 levels were assessed by enzyme-linked immunosorbent assay (ELISA). FI, CP, and RNFL were measured using OCTA. Mann-Whitney U test, unpaired t test, and Spearman's rank test were performed to analyze the data. Results: There was no difference between obesity and non-obesity group in ET-1 levels (P = 0.216). The average nasal FI, inferior FI, outer FI, and inferior CP were lower in the obesity group compared to the non-obesity group (P = 0.050, P = 0.010, P = 0.015, and P = 0.017, respectively). The average RNFL thickness in obesity group was also lower compared to the control group. However, this difference was not statistically significant (p >0.102). Conclusion: Flux index and capillary perfusion around the optic nerve head can be considered as predictors of microvascular impairment in individuals with obesity. The signs of impaired perfusion (represented by FI and CP) may precede the endothelial dysfunction (represented by ET-1)
| Item Type: | Thesis (Magister) |
|---|---|
| Identification Number: | 0424060170 |
| Uncontrolled Keywords: | Endothelin-1, Kepala Saraf Optik, Indeks Fluks, Perfusi Kapiler, RNFL, OCT |
| Divisions: | Profesi Kedokteran > Spesialis Ilmu Kesehatan Mata, Fakultas Kedokteran |
| Depositing User: | Unnamed user with username nova |
| Date Deposited: | 19 Feb 2025 03:34 |
| Last Modified: | 19 Feb 2025 03:34 |
| URI: | http://repository.ub.ac.id/id/eprint/236596 |
![[thumbnail of DALAM MASA EMBARGO]](http://repository.ub.ac.id/style/images/fileicons/text.png) |
Text (DALAM MASA EMBARGO)
Muchammad Kemal Irhamsyah.pdf Restricted to Registered users only Download (5MB) |
Actions (login required)
 |
View Item |