“Korelasi Ferritin dan Vitamin D terhadap Kadar Anti-S-RBD Pasca Vaksinasi CoronaVac pada Individu Dewasa Muda di RSUD Dr. Saiful Anwar Malang”.

Ramawati, Sherly and Prof. Dr. dr. Kusworini, M.Kes, Sp.PK, Subsp.I.K.(K), and dr. Siti Fatonah, Sp.PK, Subsp.B.D.K.T.(K). (2024) “Korelasi Ferritin dan Vitamin D terhadap Kadar Anti-S-RBD Pasca Vaksinasi CoronaVac pada Individu Dewasa Muda di RSUD Dr. Saiful Anwar Malang”. Magister thesis, Universitas Brawijaya.

Abstract

COVID-19 yang disebabkan oleh SARS-CoV-2 telah menjadi pandemi global. Untuk mengontrol pandemi, dikenalkan istilah kekebalan kelompok melalui vaksinasi. Vaksin pertama di Indonesia adalah CoronaVac yang dapat menginduksi produksi antibodi melawan protein spike dari SARS-CoV-2. Vitamin D berperan sebagai imunomodulator. Sebaliknya, feritin merupakan protein penyimpan besi imun dan memiliki efek menghambat proliferasi sel T. Penelitian ini merupakan penelitian deskriptif analitik, pengambilan data secara potong lintang dengan subyek penelitian tenaga kesehatan RSUD dr. Saiful Anwar yang telah menerima vaksinasi CoronaVac 2 kali. Sumber data adalah data primer dari hasil pemeriksaan vitamin D, ferritin dan anti-S-RBD yang diperiksa menggunakan metode Electro-Chemiluminescence Immunoassay (ECLIA). Analisis data menggunakan software IBM SPSS versi 24 Pada penelitian didapatkan total 51 subyek, 19 (37,25%) subyek laki-laki dan 32 (62,74%) perempuan. Kadar antibodi anti-SRBD pada kelompok vitamin D sufisien adalah 30,24 U/L, (10,44- 244,9) dan pada kelompok vitamin D defisien, yaitu 18,41 U/L, (3,89- 36,8); (.p=0,0039, α<0.01). Kadar anti-S-RBD pada kelompok ferritin rendah-normal adalah 22.99 U/L (3,89 - 244,9), dan pada kelompok ferritin tinggi, yaitu 21.6 U/L (10,07 - 37,1). (.p = 0,8284, α<0.01). Individu dengan status vitamin D sufisien memiliki kadar anti-SRBD lebih tinggi. Hal ini dikarenakan peran vitamin D dalam modulasi sistem imun bawaan dan adaptif. Vitamin D dapat mempengaruhi proliferasi dan diferensiasi sel T, yang merupakan komponen penting dalam respons imun adaptif. Tidak ada perbedaan pada kadar antibodi S-RBD antar kelompok ferritin karena kadar ferritin, dalam konteks respons imun memiliki peran yang lebih kompleks. Ferritin lebih dikenal sebagai biomarker inflamasi daripada sebagai faktor yang secara langsung mempengaruhi produksi antibodi. Selain itu, respons imun dipengaruhi oleh banyak faktor, termasuk genetik, usia, komorbiditas, dan status nutrisi. Kadar anti-S-RBD pada individu dewasa muda yang tidak defisiensi vitamin D lebih tinggi. Kadar anti-S-RBD pada individu dewasa muda dengan kadar ferritin yang tinggi tidak berbeda bermakna.

English Abstract

COVID-19 caused by SARS-CoV-2 has become a global pandemic. To control the pandemic, the term herd immunity through vaccination was introduced. The first vaccine in Indonesia is CoronaVac which can induce the production of antibodies against the protein spike from SARS-CoV-2. Vitamin D acts as an immunomodulator. In contrast, ferritin is an immune iron storage protein and has the effect of inhibiting T cell proliferation. This research is to determine the correlation between vitamin D and ferritin and the immune response in young adults after vaccination CoronaVac. This research is a descriptive analytical study, collecting data in a cross-sectional manner with the research subjects being health workers at RSUD dr. Saiful Anwar who has received vaccination CoronaVac 2 times. The data source is primary data from the results of vitamin D, ferritin and anti-S-RBD examinations which were examined using the method Electro-Chemiluminescence Immunoassay (ECLIA). Data analysis used IBM SPSS version 24 software In the study, there were a total of 51 subjects, 19 (37.25%) male subjects and 32 (62.74%) female subjects. The anti-S-RBD antibody level in the vitamin D deficient group was 30.24 U/L, (10.44- 244.9) and in the vitamin D deficient group, namely 18.41 U/L, (3.89- 36 .8); (.p=0.0039, α<0.01). The anti-S-RBD level in the low-normal ferritin group was 22.99 U/L (3.89 - 244.9), and in the high ferritin group, it was 21.6 U/L (10.07 - 37.1). (.p = 0.8284, α<0.01). Individuals with sufficient vitamin D status have higher anti-SRBD levels. This is due to the role of vitamin D in modulating the innate and adaptive immune system. Vitamin D can influence the proliferation and differentiation of T cells, which are important components in the adaptive immune response. There was no difference in S-RBD antibody levels between ferritin groups because ferritin levels, in the context of the immune response, have a more complex role. Ferritin is better known as an inflammatory biomarker than as a factor that directly influences antibody production. Additionally, the immune response is influenced by many factors, including genetics, age, comorbidities, and nutritional status The results of this study indicate that anti-S-RBD levels in young adults who are not vitamin D deficient are higher. Anti-S-RBD levels in young adults with high ferritin levels were not significantly different.

Item Type:	Thesis (Magister)
Identification Number:	0424060166
Uncontrolled Keywords:	SARS-CoV-2, CoronaVac, Anti-S-RBD, Vitamin D, Ferritin
Divisions:	Profesi Kedokteran > Spesialis Patologi Klinik, Fakultas Kedokteran
Depositing User:	Unnamed user with username nova
Date Deposited:	11 Feb 2025 03:02
Last Modified:	11 Feb 2025 03:02
URI:	http://repository.ub.ac.id/id/eprint/236241

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