Ardiyanti, Putri and Dr. dr. Supriono, SpPD, K-GEH and Dr. dr. Bogi Pratomo, SpPD, K-GEH (2024) Perbedaan Kadar Vitamin D dan Kepadatan Mineral Tulang pada Hepatitis Kronis dan Sirosis Hati Akibat Infeksi Virus. Magister thesis, Universitas Brawijaya.
Abstract
Pendahuluan : Osteodistrofi hepatik adalah komplikasi penyakit hati kronis seperti hepatitis dan sirosis, yang ditandai gangguan metabolisme vitamin D dan penurunan kepadatan tulang. Disfungsi hati memengaruhi metabolisme vitamin D, meningkatkan risiko osteoporosis. Tujuan : Mengevaluasi perbedaan kadar vitamin D dan kepadatan mineral tulang antara pasien hepatitis kronis dan sirosis hati akibat infeksi virus Metode: Penelitian kasus-kontrol ini melibatkan 64 pasien, terdiri dari pasien sirosis hati sebagai kasus dan hepatitis kronis sebagai kontrol. Kadar vitamin D diukur melalui serum 25-hidroksivitamin D, sedangkan kepadatan tulang dinilai dengan DXA. Data dianalisis menggunakan uji Chi-square, uji t independen, dan regresi logistik multivariat. Hasil: Dari 64 peserta (53,1% laki-laki, 46,9% perempuan), pasien sirosis memiliki kadar vitamin D lebih rendah dibandingkan hepatitis kronis (p = 0,042), dengan kemungkinan defisiensi vitamin D lebih tinggi (OR 3,286). Pasien sirosis juga lebih sering mengalami osteoporosis dibandingkan hepatitis kronis (p = 0,006) dengan risiko lebih besar (OR 12,130). Analisis multivariat menunjukkan sirosis hati (OR 20,143) dan jenis kelamin perempuan (OR 11,270) sebagai faktor risiko signifikan untuk kepadatan tulang abnormal. Kesimpulan: Terdapat perbedaan signifikan kadar vitamin D dan kejadian osteoporosis antara pasien sirosis hati dan hepatitis kronis akibat infeksi virus.
English Abstract
Background: Hepatic osteodystrophy is a serious complication of chronic liver diseases, such as hepatitis and cirrhosis, characterized by impaired vitamin D metabolism and decreased bone mineral density. Liver dysfunction affects vitamin D metabolism, increasing the risk of osteoporosis. Objective: To evaluate the differences in vitamin D levels and bone mineral density between patients with chronic hepatitis and liver cirrhosis due to viral infection. Methods: This case-control study involved 64 patients, comprising liver cirrhosis patients as cases and chronic hepatitis patients as controls. Vitamin D levels were measured using serum 25-hydroxyvitamin D, while bone mineral density was assessed using Dual X-Ray Absorptiometry (DXA). Data were analyzed using Chisquare test, independent t-test, and multivariate logistic regression. Results: Among 64 participants (53.1% male, 46.9% female), liver cirrhosis patients had significantly lower vitamin D levels compared to chronic hepatitis patients (p = 0.042), with a higher likelihood of vitamin D deficiency (OR 3.286). Liver cirrhosis patients also had a higher prevalence of osteoporosis compared to chronic hepatitis patients (p = 0.006), with a greater risk (OR 12.130). Multivariate analysis showed that liver cirrhosis (OR 20.143) and female gender (OR 11.270) were significant risk factors for abnormal bone mineral density. Conclusion: There are significant differences in vitamin D levels and osteoporosis incidence between liver cirrhosis and chronic hepatitis patients due to viral infection.
| Item Type: | Thesis (Magister) |
|---|---|
| Identification Number: | 042406 |
| Uncontrolled Keywords: | Vitamin D, Kepadatan Mineral Tulang, Hepatitis Kronis, Sirosis Hati, Osteoporosis |
| Divisions: | Profesi Kedokteran > Spesialis Ilmu Penyakit Dalam, Fakultas Kedokteran |
| Depositing User: | S Sucipto |
| Date Deposited: | 06 Feb 2025 01:42 |
| Last Modified: | 06 Feb 2025 01:42 |
| URI: | http://repository.ub.ac.id/id/eprint/235929 |
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