Hubungan Kadar Short Chain Fatty Acid pada Pasien Non Alcoholic Fatty Liver Disease dengan Obesitas Tesis Program Pendidikan Dokter Spesialis I Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Brawijaya, RSUD Dr Saiful Anwar Malang.

Safira, Zahra and Dr. dr. Syifa Mustika, SpPD, K-GEH and dr. Rulli Rosandi, SpPD, K-EMD (2024) Hubungan Kadar Short Chain Fatty Acid pada Pasien Non Alcoholic Fatty Liver Disease dengan Obesitas Tesis Program Pendidikan Dokter Spesialis I Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Brawijaya, RSUD Dr Saiful Anwar Malang. Magister thesis, Universitas Brawijaya.

Abstract

Pendahuluan : Non-Alcoholic Fatty Liver Disease (NAFLD) adalah spektrum penyakit hati yang dapat berkembang menjadi Non-Alcoholic Steatohepatitis (NASH) dan sirosis, sering kali dikaitkan dengan sindroma metabolik utamanya obesitas. Namun, NAFLD juga banyak ditemukan pada individu non-obesitas, yang menimbulkan tantangan dalam diagnosis Short Chain Fatty Acids (SCFA), produk fermentasi serat oleh mikrobiota usus, berperan penting dalam kesehatan metabolik, termasuk dalam pengaturan berat badan dan pencegahan penumpukan lemak di hati. Meski demikian, peran SCFA dalam perkembangan obesitas dan NAFLD masih belum sepenuhnya dipahami. Tujuan: Meneliti hubungan kadar SCFA pada pasien NAFLD obesitas dan nonobesitas, serta hubungannya dengan derajat NAFLD dan fibrosis. Metode: Studi cross-sectional pada 16 pasien NAFLD obesitas dan 11 NAFLD non-obesitas, dengan sampel feses untuk pengukuran SCFA melalui gas chromatography. Obesitas didefinisikan sebagai obesitas sentral yang diukur berdasarkan parameter lingkar perut. Analisis dilakukan menggunakan uji korelasi Spearman, Eta’s correlation test dan Pearson. Hasil: Hasil penelitian menunjukkan adanya hubungan signifikan antara kadar SCFA dan NAFLD pada pasien obesitas dan non-obesitas, baik total maupun masing-masing komposisinya, yaitu asetat, butirat, dan propionat (r = 0.618, p = 0.001; p = 0.012; p = 0.019; p = 0.037). Selain itu, terdapat hubungan positif yang kuat antara obesitas dan derajat NAFLD (r = 0.582, p = 0.001). Namun, hubungan antara pasien NAFLD obesitas dan non-obesitas dengan fibrosis hati tidak signifikan secara statistik (p = 0.351). Kesimpulan: Kadar SCFA signifikan lebih rendah pada pasien NAFLD obesitas dibandingkan non-obesitas. Obesitas sentral berkaitan dengan keparahan NAFLD, namun tidak menunjukkan hubungan signifikan dengan fibrosis. SCFA dan obesitas sentral berperan penting dalam patogenesis NAFLD.

English Abstract

BACKGROUND: Non-Alcoholic Fatty Liver Disease (NAFLD) is a spectrum of liver diseases that can progress to Non-Alcoholic Steatohepatitis (NASH) and cirrhosis, often associated with metabolic syndrome, primarily obesity. However, NAFLD is also frequently observed in non-obese individuals, posing a challenge in diagnosis. Short Chain Fatty Acids (SCFA), which are fermentation products of dietary fiber by gut microbiota, play an important role in metabolic health, including weight regulation and the prevention of fat accumulation in the liver. Nonetheless, the role of SCFA in the development of obesity and NAFLD is still not fully understood. OBJECTIVE: To examine the relationship of SCFA levels in obese and non-obese NAFLD patients, and its association with the degree of NAFLD and fibrosis. METHODS: Cross-sectional study in 16 obese and 11 non-obese NAFLD patients, with stool samples for SCFA measurement via gas chromatography. Obesity was defined by abdominal circumference. Analysis was performed using Spearman's correlation, Eta’s correlation test, and Pearson's test. RESULTS: The results showed a significant relationship between SCFA levels and NAFLD in both obese and non-obese patients, including acetate, butyrate, and propionate (r = 0.618, p = 0.001; p = 0.012; p = 0.019; p = 0.037). A strong positive association was found between obesity and NAFLD severity (r = 0.582, p = 0.001). However, the relationship between obese and non-obese NAFLD patients with liver fibrosis was not significant (p = 0.351). CONCLUSION: SCFA levels were significantly lower in obese than non-obese NAFLD patients. Central obesity was associated with NAFLD severity, but showed no significant association with fibrosis progression. SCFA and central obesity play an important role in the pathogenesis of NAFLD.

Item Type:	Thesis (Magister)
Identification Number:	0424060150
Uncontrolled Keywords:	SCFA, NAFLD, Obesitas Sentral, Mikrobiota Usus
Divisions:	Profesi Kedokteran > Spesialis Ilmu Penyakit Dalam, Fakultas Kedokteran
Depositing User:	Unnamed user with username nova
Date Deposited:	13 Jan 2025 04:18
Last Modified:	13 Jan 2025 04:18
URI:	http://repository.ub.ac.id/id/eprint/234651

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