Seto, Agnes Permata and Dr. dr. Supriono, SpPD, K-GEH; and Dr. dr. Bogi Pratomo, SpPD, K-GEH (2024) Hubungan Malnutrisi Berdasarkan Penilaian SGA dan TLC Terhadap Morbiditas dan Mortalitas Pasien Sirosis Hati. Magister thesis, Universitas Brawijaya.
Abstract
Pendahuluan :Malnutrisi seringkali terjadi pada pasien sirosis dan berdampak buruk pada prognosis. Subjective Global Assessment (SGA) dan Total Lymphocyte Count (TLC) adalah metode penilaian status nutrisi yang mudah dan cepat pada pasien sirosis hati. Penelitian tentang hubungan antara malnutrisi terhadap morbiditas dan mortalitas masih terbatas. Tujuan : Untuk mengevaluasi hubungan antara malnutrisi, yang diukur menggunakan Subjective Global Assessment (SGA) dan Total Lymphocyte Count (TLC), terhadap morbiditas dan mortalitas pada pasien dengan sirosis hati. Metode: Desain penelitian menggunakan observasional analitik dengan pendekatan kohort prospektif yang melibatkan 132 pasien sirosis. Data yang dikumpulkan terdiri dari karakteristik demografis, etiologi, morbiditas, dan mortalitas. Morbiditas seperti asites, perdarahan varises esofagus, ensefalopati hepatikum, dan mortalitas dianalisis. Selanjutnya relative risk (RR) dihitung untuk menentukan risiko yang terkait dengan malnutrisi. Data dianggap signifikan jika pvalue < 0,05. Hasil: Malnutrisi berdasarkan SGA terhadap asites (RR = 5,89, p< 0,001), perdarahan varises esofagus (RR = 6,22, p= < 0,001), ensefalopati hepatikum ( RR=1,72, p=0,02), dan mortalitas (RR=1.57, p=0,10). Malnutrisi berdasarkan TLC terhadap asites (RR =3,48, p=0,03), perdarahan varises esofagus (RR = 2,21, p=0,01), ensefalopati hepatikum ( RR=1,08, p=086), dan mortalitas (RR=1,08, p=0,88). Kesimpulan: Malnutrisi berdasarkan SGA meningkatkan kejadian asites, perdarahan varises esofagus, asites, dan ensefalopati hepatik tapi tidak signifikan meningkatkan mortalitas. Malnutrisi berdasarkan TLC meningkatkan kejadian asites dan perdarahan varises esofagus tapi tidak signifikan meningkatkan kejadian ensefalopati hepatikum dan mortalitas.
English Abstract
BACKGROUND: Malnutrition frequently occurs in patients with cirrhosis and adversely affects prognosis. Subjective Global Assessment (SGA) and Total Lymphocyte Count (TLC) are easy and quick methods for assessing nutritional status in patients with liver cirrhosis. The relationship between malnutrition and morbidity and mortality remains limited. OBJECTIVE: To evaluate the relationship between malnutrition, measured using Subjective Global Assessment (SGA) and Total Lymphocyte Count (TLC), and morbidity and mortality in patients with liver cirrhosis. METHODS: The study design used an analytical observational approach with a prospective cohort involving 132 patients with cirrhosis. The data collected included demographic characteristics, etiology, morbidity, and mortality. Morbidity such as ascites, variceal bleeding, hepatic encephalopathy, and mortality were analyzed. Subsequently, the relative risk (RR) was calculated to determine the risk associated with malnutrition. Data were considered significant if the p-value was < 0.05. RESULTS: Malnutrition based on SGA was associated with ascites (RR = 5.89, p = 0.00), variceal bleeding (RR = 6.22, p = 0.00), hepatic encephalopathy (RR = 1.72, p = 0.02), and mortality (RR = 1.57, p = 0.10). Malnutrition based on TLC was associated with ascites (RR = 3.48, p = 0.03), variceal bleeding (RR = 2.21, p = 0.01), hepatic encephalopathy (RR = 1.08, p = 0.86), and mortality (RR = 1.08, p = 0.88). CONCLUSION: Malnutrition based on SGA increases the incidence of ascites, upper gastrointestinal bleeding, and hepatic encephalopathy, but does not increase mortality. Malnutrition based on TLC increases the incidence of ascites and variceal bleeding, but is not associated with the occurrence of hepatic encephalopathy and mortality.
| Item Type: | Thesis (Magister) |
|---|---|
| Identification Number: | 0424060145 |
| Uncontrolled Keywords: | Malnutrisi, Sirosis Hati, Morbiditas, Mortalitas |
| Divisions: | Profesi Kedokteran > Spesialis Ilmu Penyakit Dalam, Fakultas Kedokteran |
| Depositing User: | Unnamed user with username nova |
| Date Deposited: | 13 Jan 2025 01:38 |
| Last Modified: | 13 Jan 2025 01:38 |
| URI: | http://repository.ub.ac.id/id/eprint/234613 |
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