Claudia Herda, Asyari and dr. Suryanti Dwi Pratiwi, Sp.P(K), and dr. Teguh Rahayu Sartono, Sp.P(K) (2024) Efek Pemberian Jinten Hitam (Nigella Sativa) pada HIF-1 (Hypoxia Inducible Factor) dan NLR (Neutrophil Lymphocyte Ratio) Pasien Kanker Paru yang Menjalani Kemoterapi di RSUD Dr. Saiful Anwar Jawa Timur. Magister thesis, Universitas Brawijaya.
Abstract
Latar Belakang: Kanker paru merupakan salah satu jenis kanker dengan progresivitas yang cepat dan prognosis yang buruk. Penelitian ini bertujuan untuk menganalisis kadar HIF-1 dan NLR antara pasien kanker paru yang diberi kemoterapi dan jinten hitam (Nigella sativa) dengan pasien kemoterapi standar. Metode: Penelitian ini menggunakan desain Experimental Nonequivalent Control Group Design dengan melibatkan pasien kanker paru di RSUD dr. Saiful Anwar Jawa Timur yang belum pernah mendapat kemoterapi. Sampel penelitian dipilih menggunakan random sampling, dan jumlah sampel yang diikutsertakan adalah 21 orang. Hasil: Hasil penelitian menunjukkan bahwa pemberian ekstrak jinten hitam secara per oral 2x500mg selama sembilan minggu pada pasien kanker paru yang menjalani kemoterapi dapat menyebabkan penurunan yang signifikan dalam kadar HIF-1 (p=0.009) dan NLR (p=0.009). Kesimpulan: Pemberian ekstrak jinten hitam berpotensi menurunkan kadar HIF- 1 dan NLR pada pasien kanker paru yang menjalani kemoterapi. Kata kunci: Kanker Paru, Nigella sativa, Hypoxia-Inducible Factor, Neutrophil-toLymphocyte Ra
English Abstract
Backgorund: Lung cancer is a type of cancer with rapid progression and poor prognosis. This study aims to analyze HIF-1 and NLR levels between lung cancer patients who received chemotherapy and black cumin (Nigella sativa) and standard chemotherapy patients. Methods: This research used an Experimental Nonequivalent Control Group Design involving lung cancer patients at RSUD dr. Saiful Anwar, East Java, who has never received chemotherapy. The research sample was selected using random sampling, and the number of samples included was 21 people. Results: The results of the study showed that administering 2x500mg of black cumin extract orally for nine weeks to lung cancer patients undergoing chemotherapy could cause a significant reduction in HIF-1 levels (p=0.009) and NLR (p=0.009). Conclusion: The conclusion of this study is that administration of black cumin extract has the potential to reduce HIF-1 and NLR levels in lung cancer patients undergoing chemotherapy.
| Item Type: | Thesis (Magister) |
|---|---|
| Identification Number: | 0424060054 |
| Uncontrolled Keywords: | Kanker Paru, Nigella sativa, Hypoxia-Inducible Factor, Neutrophil-toLymphocyte Ra |
| Divisions: | Profesi Kedokteran > Spesialis Ilmu Penyakit Dalam, Fakultas Kedokteran |
| Depositing User: | Unnamed user with username nova |
| Date Deposited: | 01 Oct 2024 01:27 |
| Last Modified: | 01 Oct 2024 01:27 |
| URI: | http://repository.ub.ac.id/id/eprint/225352 |
![[thumbnail of DALAM MASA EMBARGO]](http://repository.ub.ac.id/style/images/fileicons/text.png) |
Text (DALAM MASA EMBARGO)
Claudia Herda.pdf Restricted to Registered users only Download (4MB) |
Actions (login required)
 |
View Item |