Hubungan Antara Faktor Resiko Klinis Dan Komorbid Dengan Tingkat Mortalitas Pasien Kandidiasis Invasifdi Intensive Care Unit Rsud Dr. Saiful Anwar Malang

Sintani, Rinni and dr. Wiwi Jaya, Sp.An-TI., Subsp. TI (K) and dr. Arie Zainul Fatoni, Sp.An-TI., Subsp. TI (K) and dr. Nurima Dyah Puji Hastuti, M. Ked. Klin., Sp. MK (2024) Hubungan Antara Faktor Resiko Klinis Dan Komorbid Dengan Tingkat Mortalitas Pasien Kandidiasis Invasifdi Intensive Care Unit Rsud Dr. Saiful Anwar Malang. Magister thesis, Universitas Brawijaya.

Abstract

Latar belakang: Insiden infeksi jamur dilaporkan semakin meningkat di ICU. Candida adalah jamur yang paling sering menyebabkan kandidiasis invasif. Prevalensi kandidiasis invasif di ICU secara nasional dilaporkan 8%-12,3%. Tujuan: Untuk mengetahui faktor resiko yang berperan terhadap kejadian kandidiasis invasif dan tingkat mortalitas pasien dewasa di ICU. Metode: Studi retrospektif, desain cross sectional berdasarkan data sekunder pasien terdiagnosis kandidiasis invasif di ICU RSUD Dr. Saiful Anwar Malang (RSSA) sejak Januari 2019-Desember 2022 berdasarkan kriteria inklusi dan eksklusi. Dilakukan pencatatan data karakteristik, data faktor resiko pejamu, faktor resiko komorbid, faktor resiko intervensi medis dan dihubungkan dengan kejadian kandidiasis invasif dan tingkat mortalitas pasien. Hasil: Pasien berjumlah 182, hasil uji statistik chi square bermakna terhadap kejadian kandidiasis (pemakaian steroid {p=0,028}), bermakna terhadap tingkat mortalitas (sepsis {p=0,000} dan DM tipe 2 {p=0,016}), uji korelasi spearman bermakna terhadap kejadian kandidiasis invasif (usia {p=0,016;r=0,179} dan pemakaian steroid {p=0,028;r=-0,163}), bermakna terhadap mortalitas (usia {0,040;r=-0,152}, sepsis {p=0,000;r=0,554} dan DM tipe 2 {0,016;r=0,178}), uji multivariat dengan inner model bermakna terhadap kejadian kandidiasis (usia {p=0,021;”p”=0,177}, BMI {p=0,012;”p”=0,178}, steroid {p=0,002;”p”=-0,182} dan keganasan {p=0,002;”p”=-0,202}), bermakna terhadap tingkat mortalitas (sepsis {p=0,000;”p”=0,529}, DM tipe 2 {p=0,032;”p”=0,122}). Kesimpulan: Pada pasien kandidiasis invasif yang dirawat di intensive care unit di RSSA, ditemukan hubungan bermakna antara faktor resiko dengan kejadian kandidiasis invasive, yaitu usia, BMI, pemakaian steroid dan keganasan dan ditemukan hubungan bermakna antara faktor resiko dengan tingkat mortalitas pasien, yaitu usia, sepsis dan DM tipe 2.

English Abstract

Background: The incidence of fungal infection is reported increased in the ICU. Candida is the most common fungus that causes invasive candidiasis. To determine the risk factors contributing to the occurrence of invasive candidiasis and the mortality rate of adult patients in the ICU. Method: A retrospective cross-sectional study design based on data of patients diagnosed with invasive candidiasis in the ICU from January 2019 to December 2022, based on inclusion and exclusion criteria, characteristics, risk factors, comorbid, medical intervention related to invasive candidiasis and patient mortality rate. Results: The study included 182 patients. Statistically significant chi-square test results were found for the occurrence of candidiasis (steroid use {p=0.028}) and for mortality rate (sepsis {p=0.000} and type 2 diabetes {p=0.016}). The Spearman correlation test showed significant correlation with the occurrence of invasive candidiasis (age {p=0.016;r=0.179} and steroid use {p=0.028;r=-0.163}) and for mortality (age {0.040;r=-0.152}, sepsis {p=0.000;r=0.554}, and type 2 diabetes {0.016;r=0.178}). The multivariate test with an inner model showed significant results for the occurrence of candidiasis (age {p=0.021;”p”=0.177}, BMI {p=0.012;”p”=0.178}, steroid use {p=0.002;”p”=-0.182}, and malignancy {p=0.002;”p”=-0.202}), and for the mortality rate (sepsis {p=0.000;”p”=0.529} and type 2 diabetes {p=0.032;”p”=0.122}). Conclusion: Patients with invasive candidiasis treated in the intensive care unit in RSSA, significant correlation we have found between risk factors and the occurrence of invasive candidiasis, such as age, BMI, steroid use, and malignancy. Significant correlation between risk factors and mortality rate of the patient, such as age, sepsis, and diabetes type 2.

Item Type:	Thesis (Magister)
Identification Number:	042406
Uncontrolled Keywords:	Faktor resiko, kejadian kandidiasis invasif, tingkat mortalitas pasien.-Risk factors, invasive candidiasis, patient mortality rate.
Divisions:	Profesi Kedokteran > Spesialis Anestesiologi dan Terapi Intensif, Fakultas Kedokteran
Depositing User:	Unnamed user with username nova
Date Deposited:	12 Sep 2024 05:43
Last Modified:	12 Sep 2024 05:43
URI:	http://repository.ub.ac.id/id/eprint/225343

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