Febrianto, dr.Aditya Rachmat and dr. Hery Susilo, SpB, Subsp.Onk(K) and r. Kenty Wantri Anita, M.Kes, Sp.PA(K) and Dr. Ir. Solimun, M.S (2024) Perbedaan Ekspresi VEGF Pasien Kanker Payudara Subtipe Human Epidermal Growth Factor Receptor 2 dan Triple Negative Breast Cancer. Sarjana thesis, Universitas Brawijaya.
Abstract
Penelitian ini bertujuan untuk menganalisis perbedaan dalam ekspresi Vascular Endothelial Growth Factor (VEGF) dan reseptor Human Epidermal Growth Factor Receptor 2 (HER2) pada kanker payudara subtipe TripleNegative Breast Cancer (TNBC) dan HER2-positif. Desain penelitian yang digunakan adalah cross-sectional dengan melibatkan 38 pasien kanker payudara, terdiri dari 19 pasien TNBC dan 19 pasien HER2-positif, yang dirawat di RSUD dr. Saiful Anwar Malang. Ekspresi VEGF dievaluasi melalui pewarnaan imunohistokimia dan dibandingkan antara kedua kelompok. Berdasarkan hasil penelitian, terdapat perbedaan signifikan dalam ekspresi Vascular Endothelial Growth Factor (VEGF) antara pasien kanker payudara tipe Triple-Negative Breast Cancer (TNBC) dan Human Epidermal Growth Factor Receptor 2 (HER2). Rata-rata ekspresi VEGF pada pasien TNBC adalah 46,82 dengan standar deviasi 13,22. Hasil uji statistik menunjukkan nilai p-value sebesar 0,004, yang menunjukkan adanya perbedaan yang signifikan dalam ekspresi VEGF antara kedua kelompok. Hasil analisis menunjukkan bahwa ekspresi VEGF pada pasien kanker payudara subtipe HER2 secara signifikan lebih tinggi daripada pada subtipe TNBC. Temuan ini memberikan wawasan tambahan tentang karakteristik biomolekuler kanker payudara yang berbeda, serta potensi implikasi klinis dalam pengembangan strategi diagnosis dan terapi yang lebih terarah.
English Abstract
This study aims to analyze differences in the expression of Vascular Endothelial Growth Factor (VEGF) and Human Epidermal Growth Factor Receptor 2 (HER2) receptors in Triple-Negative Breast Cancer (TNBC) and HER2-positive subtypes of breast cancer. The research design used was cross-sectional, involving 38 breast cancer patients, consisting of 19 TNBC patients and 19 HER2-positive patients, who were treated at RSUD dr. Saiful Anwar Malang. VEGF expression was evaluated via immunohistochemical staining and compared between the two groups. Based on the research results, there are significant differences in the expression of Vascular Endothelial Growth Factor (VEGF) between patients with Triple-Negative Breast Cancer (TNBC) and Human Epidermal Growth Factor Receptor 2 (HER2) breast cancer. The average expression of VEGF in TNBC patients was 46.82 with a standard deviation of 13.22. The statistical test results showed a p-value of 0.004, which indicated a significant difference in VEGF expression between the two groups. The results of the analysis showed that VEGF expression in HER2 subtype breast cancer patients was significantly higher than in TNBC subtype. These findings provide additional insight into the biomolecular characteristics of distinct breast cancers, as well as potential clinical implications in the development of more targeted diagnostic and therapeutic strategies.
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | 0424060051 |
| Uncontrolled Keywords: | Kanker Payudara, VEGF, HER2, TNBC, diagnosa |
| Divisions: | Profesi Kedokteran > Spesialis Ilmu Bedah, Fakultas Kedokteran |
| Depositing User: | Unnamed user with username nova |
| Date Deposited: | 28 Aug 2024 06:54 |
| Last Modified: | 28 Aug 2024 06:54 |
| URI: | http://repository.ub.ac.id/id/eprint/224753 |
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