Afifah, Nabilah and Dr. dr. Nina Handayani, Sp.M(K) and Dr. dr. Nadia Artha Dewi, Sp.M(K) (2024) Hubungan Hba1c Dan Retinopati Diabetik Terhadap Ketebalan Kornea Sentral Dan Densitas Sel Endotel Kornea Pada Penderita Diabetes Melitus Tipe Ii. Magister thesis, Universitas Brawijaya.
Abstract
Bertujuan untuk mengetahui hubungan peningkatan HbA1c dan kedaan retinopati diabetik terhadap ketebalan kornea sentral dan densitas sel endotel pada pasien diabetes melitus tipe II. Metode : Merupakan penelitian cross-sectional yang dilakukan dari bulan Juli 2023 sampai Februari 2024 di Rumah Sakit Saiful Anwar Malang. Pemeriksaan ketebalan korena sentral dan densitas sel endotel diakukan dengan spekular mikroskop non kontak merk Nidek tipe CEM-530. Pasien merupakan pasien diabetes melitus tipe II yang dibagi berdasarkan non retinopati diabetik dan retinopati diabetik. Hasil : Hasil penelitian ini terdiri dari 101 pasien dengan diabetes melitus tipe II dimana menunjukkan paling banyak adalah pasien dengan retinopati diabetik (67.3%). Terdapat hubungan yang signifikan antara HbA1c dengan densitas sel endotel (r=-0.340, p=0.000), namun tidak didapatkan hubungan dengan ketebalan kornea sentral. Retinopati diabetik tidak berhubungan dengan ketebalan kornea sentral (p=0.546) maupun dengan densitas sel endotel (p=0.081). Pada analisis sekunder didapatkan hubungan HbA1c dengan hexagonal (r=-0.294, p=0.003) dan hubungan signifikan antara retinopati diabetik dengan sel hexagonal (r=- 0.333, p0.001) dan koefisien variasi (r=-0.324, p=0.001). Kesimpulan : Penelitian ini menunjukkan bahwa semakin tinggi HbA1c mempunyai densitas sel endotel yang lebih rendah, namun tidak berhubungan dengan ketebalan kornea sentral. Retinopati diabetik tidak berjalan dengan peningkatan ketebalan kornea sentral maupun penurunan densitas sel endotel.
English Abstract
To understand the correlation of HbA1c and diabetic retinopathy to central corneal thickness and corneal endothelial cell density in patients with typeII diabetes mellitus. Methods: This cross-sectional study was conducted from July 2023 to February 2024 at Saiful Anwar General Hospital. Central corneal thickness and corneal endothelial cell density were examined using non-contact specular microscope NIDEK CEM-530. Patient groups are diabetic mellitus patients with either diabetic retinopathy or non-diabetic retinopathy. Results: We included 101 patients with type-II diabetes mellitus, most of which (67.3%) had diabetic retinopathy. There is significant correlation between HbA1c and endothelial cell density (r=-0.340,p=0.000), but not between HbA1c and central corneal thickness. Diabetic retinopathy was nor correlated to both central corneal thickness (p=0.546) and endothelial cell density (p=0.081). As secondary results, we found that there were correlation between HbA1c and hexagonal (r=- 0.294,p=0.003) and significant correlation between diabetic retinopathy and hexagonal (r =-0.333,p=0.001) and coefficient variant (r=-0.324,p=0.001). Conclusion: This study found out the the higher the HbA1c, corneal endothelial cell density decreased but no correlation was found to central corneal thickness. Diabetic retinopathy did not correlate to either central corneal thickness or corneal endothelial cell density.
| Item Type: | Thesis (Magister) |
|---|---|
| Identification Number: | 0424060023 |
| Uncontrolled Keywords: | HbA1c, retinopati diabetik, ketebalan kornea sentral, densitas sel endotel kornea, diabetes mellitus tipe II |
| Divisions: | Profesi Kedokteran > Spesialis Ilmu Kesehatan Mata, Fakultas Kedokteran |
| Depositing User: | Unnamed user with username nova |
| Date Deposited: | 13 Jun 2024 07:00 |
| Last Modified: | 13 Jun 2024 07:00 |
| URI: | http://repository.ub.ac.id/id/eprint/220088 |
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