Sitinjak, Bagas Parulian and drg. Miftakhul Cahyati, Sp. PM and Prof. Dr. drg. M. Chair Effendi, SU., Sp. KGA. (2024) Nanogel Propolis Dan Asap Cair Terhadap Ekspresi TNF-α Pada Penyembuhan Luka Ulkus Traumatik Rongga Mulut: Studi In Vivo. Sarjana thesis, Universitas Brawijaya.
Abstract
Latar Belakang: Ulkus traumatik banyak ditemukan pada rongga mulut dan disebabkan oleh trauma. Flavonoid, CAPE, dan fenol pada bahan propolis dan asap cair memiliki sifat anti-inflamasi. Penggunaan bahan yang diformulasikan menjadi nanogel dapat meningkatkan proses penetrasi bahan pada kulit. Hal ini dapat mempercepat penyembuhan ulkus traumatik pada rongga mulut. Tujuan: Mengetahui pengaruh nanogel propolis dan asap cair terhadap ekspresi TNF-α pada penyembuhan ulkus traumatik pada rongga mulut. Metode: Tikus dibagi menjadi 3 kelompok; kelompok kontrol positif yang diberi obat triamcinolone 0,1%, kelompok perlakuan 1 yang diberi nanogel propolis, dan kelompok perlakuan 2 yang diberi nanogel propolis dan asap cair. Setiap kelompok dilakukan pengulangan sebanyak 9 kali dan penilaian time series sebanyak 3 kali pada hari ketiga, kelima, dan ketujuh. Dilakukan pengorbanan pada hari ketiga, kelima, dan ketujuh dan dilakukan pengambilan sampel, serta pengamatan histologi untuk menghitung jumlah sel TNF-α. Hasil dan Pembahasan: Terdapat perbedaan yang signifikan jumlah rerata TNF-α pada semua kelompok perlakuan. Hasil statistik menunjukkan perbedaan pada kelompok perlakuan yang dibandingkan pada hari ke-5 (Sig = 0,000) dan hari ke-7 (Sig = 0,017). Kesimpulan: Terdapat perbedaan jumlah ekspresi TNF-α yang signifikan setelah pemberian nanogel ekstrak propolis dan asap cair pada penyembuhan pada ulkus traumatik rongga mulut hewan coba tikus.
English Abstract
Backgorund: Traumatic ulcers are brought on by trauma and are frequently seen in the mouth cavity. Flavonoid, CAPE, and fenol in propolis and liquid smoke have an anti-inflammatory effect. The use of substances formulated into nanogels can increase the penetration process of the active compound into the skin. Both of these substances can be utilized to accelerate up the healing of traumatic oral cavity ulcers. Objective: To determine the effect of propolis and liquid smoke nanogel on TNF-α expression in traumatic ulcers wound healing in the oral cavity. Methods: This study used three groups of male Ratus norvegicus rats, consisting of a positive control group which was given 0.1% triamcinolone, treatment group 1 which was given propolis nanogel, and treatment group 2 which was given propolis and liquid smoke nanogel. Each group was repeated 9 times and the time series was assessed 3 times on the third, fifth and seventh days. Sacrifice was carried out on the third, fifth and seventh days and samples were taken, as well as histological observations to count the number of TNF-α cells. Results and Discussion: There were significant differences in the mean amount of TNF-α in all treatment groups. Statistical results showed differences in the treatment groups compared on day 5 (Sig = 0.000) and day 7 (Sig = 0.017). Conclusion: There are differences in the number of TNF-α expression after administration of propolis and liquid smoke extract nanogel in traumatic ulcers wound healing in the oral cavity of experimental rats.
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | 0524140032 |
| Uncontrolled Keywords: | Nanogel, Propolis, Asap Cair, TNF-α, Ulkus traumatik Nanogel, Propolis, Liquid Smoke, TNF-α, Traumatic Ulcer |
| Divisions: | Fakultas Kedokteran Gigi > Kedokteran Gigi |
| Depositing User: | soegeng sugeng |
| Date Deposited: | 03 Jun 2024 03:56 |
| Last Modified: | 03 Jun 2024 03:56 |
| URI: | http://repository.ub.ac.id/id/eprint/220029 |
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