Nanda, Britania Laila and dr. Hikmawan Wahyu Sulistomo, PhD and Dr. dr. Sutrisno,, SpOG (K) (2024) Pengaruh Paparan Sub Akut Mikro-nano Plastik Polyethylene (PE) per Inhalasi terhadap Gambaran Histopatologi Kelenjar mammae Tikus Putih (Rattus Norvegicus) strain wistar Betina Usia Produktif. Sarjana thesis, Universitas Brawijaya.
Abstract
Mayoritas barang-barang peralatan rumah tangga berasal dari plastik yang terbuat dari sintetis minyak bumi dan hasil dari proses polimerisasi. Salah satu jenis plastik adalah Polyethylene (PE). Polyetylene (PE) mengandung senyawa antimoni trioksida yang bersifat karsinogenik dalam tubuh jika masuk dalam jumlah berlebih sehingga memicu terjadinya kanker dan terjadi stres oksidatif yang dapat diamati dengan pengukuran kadar malondialdehyde (MDA) dalam tubuh. Penelitian ini bertujuan untuk untuk mengetahui apakah terdapat proliferasi sel abnormal pada duktus laktiferus dan acini kelenjar mammae serta adanya penigkatan kadar MDA. Metode penelitian yang dilakukan yaitu true experimental design dengan rancangan penelitian Randomize Post Test Only Group Design. Penelitian ini menggunakan organ mammae dan darah tikus putih betina yang telah dipapar PE selama 28 hari. Didapatkan hasil penelitian dengan hasil yang berbeda signifikan terhadap gambaran histopatologi dan kadar MDA pada mammae berdasarkan hasil uji Independent T-Test pada jumlah lapisan sel duktus laktiferus, acini, dan jumlah acini (t<0,05) dan uji Mann-Whitney pada kadar MDA (t<0,05). Hasil akhir dari penelitian ini adalah terdapat perubahan yang signfikan terhadap gambaran histopatologi dan kadar MDA pada kelenjar mammae yang dipapar plastik jenis Polyethylene (PE).
English Abstract
The majority of household items are mademade from plastics that are made from synthetic petroleum and result from the process ofpolymerization process. One type of plastic is Polyethylene (PE). Polyethylene (PE) contains an antimony trioxide compound that is carcinogenic in the body if it enters the body in excessive amounts, triggering cancer and cancer the body if it enters in excessive amounts, triggering cancer and oxidative stress that can be observed with the oxidative stress that can be observed by measuring malondialdehyde (MDA) levels in the body. This study aims to determine whether there is abnormal cell proliferation in the lactiferous ducts and acini of the mammary glands and an increase in MDA levels. The research method used was true experimental design with the research design Randomize Post Test Only Group Design. This study used mammary organs and blood of female white rats that have been exposed to PE for 28 days. The results obtained research with significantly different results on the histopathology picture and MDA levels in the mammae based on the results of the and MDA levels in the mammae based on the results of the Independent T-Test test on the number of lactiferous duct cell layers, acini, and the number of acini (t<0.05) and Mann-Whitney test on MDA levels (t<0.05). The final result of this study is that there is a significant change Significant changes to the histopathological picture and MDA levels in the mammary gland exposed to Polyethylene (PE) plastic.
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | 0524060103 |
| Uncontrolled Keywords: | polyethylene, mikro-nano plastik, proliferasi sel, kanker payudara-polyethylene, micro-nano plastic, cell proliferation,breast cancer. |
| Divisions: | Fakultas Kedokteran > Kebidanan |
| Depositing User: | soegeng sugeng |
| Date Deposited: | 15 May 2024 02:47 |
| Last Modified: | 15 May 2024 02:47 |
| URI: | http://repository.ub.ac.id/id/eprint/218768 |
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