Hubungan Kadar Short Chain Fatty Acid Dengan Sindrom Metabolik Dan Derajat Fibrosis Hati Pada Pasien Non Alcoholic Fatty Liver Disease.

Faridah, Amirah and dr. Syifa Mustika, SpPD-KGEH and Dr. dr. Bogi Pratomo W., SpPD-KGEH (2023) Hubungan Kadar Short Chain Fatty Acid Dengan Sindrom Metabolik Dan Derajat Fibrosis Hati Pada Pasien Non Alcoholic Fatty Liver Disease. Magister thesis, Universitas Brawijaya.

Abstract

Pendahuluan: Saluran pencernaan dan hati memiliki interaksi anatomis dan fungsional yang kuat, yang disebut dengan gut-liver axis (GLA). GLA terdiri dari komponen-komponen yang kompleks, dimana perubahan pada salah satu komponen seperti disbiosis mikrobiota usus, dapat berpengaruh terhadap fungsi hati. Disbiosis mikrobiota usus dapat dinilai dari perubahan hasil fermentasi mikrobiota usus yaitu asam lemak rantai pendek (SCFA) yang terdiri dari asetat, propionat, dan butirat. Penelitian ini bertujuan untuk mengetahui perbedaan kadar SCFA pada pasien NAFLD dibandingkan kontrol serta hubungan kadar SCFA dengan sindrom metabolik dan derajat fibrosis hati. Tujuan: Mengidentifikasi hubungan kadar SCFA dengan sindrom metabolik, mengidentifikasi hubungan kadar SCFA dengan derajat fibrosis hati, serta mengukur dan membandingkan kadar SCFA pasien NAFLD dengan subjek kontrol. Metode: Studi cross sectional terhadap 27 pasien NAFLD dan 10 subjek kontrol dengan sampel penelitian berupa feses. Derajat fibrosis hati diukur menggunakan Transient Elastography dan kadar SCFA diukur menggunakan teknik pemeriksaan gas chromatography. Analisis data dengan uji Mann-whitney, independent T-test dan uji korelasi Spearman. Hasil: Terdapat hubungan antara kadar SCFA dengan sindrom metabolik dengan korelasi negatif (r=-0,381; p<0,05), terdapat hubungan antara kadar SCFA dengan derajat fibrosis hati pasien NAFLD dengan korelasi negatif (r=-0,665; p<0,05), dan didapatkan penurunan signifikan kadar SCFA pada pasien NAFLD dibandingkan subjek kontrol (total SCFA p=0,001, asam asetat p<0,001, asam propionat p=0,005, asam butirat p<0,001). Kesimpulan: Terdapat penurunan signifikan kadar SCFA pada pasien NAFLD dibandingkan subjek kontrol. Semakin rendah kadar SCFA berhubungan dengan semakin tinggi resiko terjadinya sindrom metabolik dan semakin tinggi derajat fibrosis hati pada pasien NAFLD.

English Abstract

Introduction: The gut-liver axis consists of complex components. Changes in one of the components, such as gut microbiota dysbiosis, can affect liver function. Gut dysbiosis can be assessed by changes in the fermentation products of gut microbiota, namely short-chain fatty acids (SCFA) consisting of acetate, propionate, and butyrate. This study aims to determine the difference in SCFA levels in NAFLD patients compared to controls and the relationship between SCFA levels with metabolic syndrome and the degree of liver fibrosis. Objective: Identify the relationship between SCFA levels and metabolic syndrome, identify the relationship between SCFA levels and the degree of liver fibrosis, and compare SCFA levels in NAFLD patients with control subjects. Methods: Cross-sectional study of 27 NAFLD patients and 10 control subjects with stool samples. The degree of liver fibrosis was measured using Transient Elastography and SCFA levels were measured using the gas chromatography technique. Data were analyzed using the Chi-square test, independent T-test, and Spearman correlation test. Results: There is a negative correlation between SCFA levels with metabolic syndrome (r=-0.381; p<0.05) and with degree of liver fibrosis (r=-0.665; p<0.05), and there was a significant decrease in SCFA levels in NAFLD patients compared to control subjects (total SCFA p=0.001, acetic acid p<0.001, propionic acid p=0.005, butyric acid p<0.001). Conclusion: There was a significant decrease in SCFA levels in NAFLD patients compared to control subjects. The lower SCFA levels are associated with a higher risk of metabolic syndrome and a higher degree of liver fibrosis in NAFLD patients.

Item Type:	Thesis (Magister)
Identification Number:	0423060116
Uncontrolled Keywords:	SCFA, Sindrom Metabolik, Fibrosis Hati, NAFLD
Divisions:	Profesi Kedokteran > Spesialis Ilmu Penyakit Dalam, Fakultas Kedokteran
Depositing User:	Endang Susworini
Date Deposited:	26 Jan 2024 02:36
Last Modified:	26 Jan 2024 02:36
URI:	http://repository.ub.ac.id/id/eprint/214226

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