Putri, Elita Verina Adikara and Dr. dr. Krisni Subandijah, Sp.A(K) and Dr. dr. Harjoedi Adji Tjahjono, Sp.A(K) (2023) Perbedaan Kadar Vitamin 25-OH-D antara Nefritis Lupus dengan Lupus Eritematosus Sistemik pada Anak. Sarjana thesis, Universitas Brawijaya.
Abstract
Lupus eritematosus sistemik (LES) adalah penyakit autoimun yang bisa berdampak pada manifestasi klinis di beberapa organ tubuh. Nefritis lupus termasuk salah satu konsekuensi manifestasi klinis LES derajat berat pada ginjal. LES dan nefritis lupus dapat menurunkan kadar vitamin D dalam tubuh karena faktor insufisiensi ginjal dan penggunaan obat-obatan kortikosteroid. Di Indonesia belum terdapat penelitian yang melihat perbandingan kadar vitamin D antara nefritis lupus dan LES pada anak. Sehingga, tujuan umum penelitian ini yaitu untuk mengetahui perbedaan kadar vitamin 25-OH-D antara nefritis lupus dengan LES pada anak. Penelitian analitik observasional ini menggunakan metode cross section pada subjek penelitian 17 pasien LES anak dan 17 pasien nefritis lupus anak di RSUD Dr. Saiful Anwar Malang. Data hasil penelitian menunjukkan kadar vitamin 25-OH-D pada pasien LES anak maupun nefritis lupus anak paling banyak tergolong insufisiensi. Analisis data dengan uji komparatif mann whitney menunjukkan terdapat perbedaan signifikan pada kadar vitamin 25-OH-D antara nefritis lupus dengan LES (p=0,004). Analisis data dengan uji korelatif spearmen menunjukkan terdapat hubungan signifikan antara klasifikasi kadar vitamin 25-OHD dengan peningkatan keparahan LES pada terjadinya nefritis lupus (p=0,003). Penelitian ini dapat disimpulkan yaitu kadar vitamin 25-OH-D pasien nefritis lupus anak lebih rendah dibandingkan dengan pasien LES anak, serta klasifikasi kadar vitamin 25-OH-D berkolerasi negatif dengan keparahan penyakit LES pada anak dengan terjadinya nefritis lupus.
English Abstract
Systemic lupus erythematosus (SLE) is an autoimmune disease that can impact clinical manifestations in several organs. Lupus nephritis is one of the consequences of clinical manifestations severe SLE on the kidneys. SLE and lupus nephritis can reduce vitamin D levels in the body due to renal insufficiency and the use of corticosteroid drugs. In Indonesia there is no research that looks at the comparison of vitamin D levels between lupus nephritis and SLE in children. Therefore, this study had general aim to compare vitamin 25-OH-D levels between lupus nephritis and SLE in children. This observational analytic study used cross section method on research subjects is 17 pediatric SLE patients and 17 pediatric lupus nephritis patients at RSUD Dr. Saiful Anwar Malang. The results of the research showed that the levels of vitamin 25-OH-D in both pediatric SLE and lupus nephritis patients were mostly classified as insufficiency. Data analysis using the Mann Whitney comparative test showed that there was a significant difference in 25-OH-D vitamin levels between lupus nephritis and SLE (p=0.004). Data analysis using the Spearmen correlative test showed that there was a significant relationship between the classification of vitamin 25-OH-D levels and the increasing of severity SLE in the occurrence of lupus nephritis (p=0.003). This research can be concluded that vitamin 25-OH-D levels in pediatric lupus nephritis patients are lower than in pediatric SLE patients, and the classification of 25-OHD vitamin levels has a negative correlation with the severity of SLE disease in children with involvement of lupus nephritis.
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | 0523060048 |
| Uncontrolled Keywords: | Nefritis Lupus, Lupus Eritematosus Sistemik, Vitamin D |
| Divisions: | Fakultas Kedokteran > Pendidikan Dokter |
| Depositing User: | Endang Susworini |
| Date Deposited: | 31 Jan 2024 04:47 |
| Last Modified: | 31 Jan 2024 04:47 |
| URI: | http://repository.ub.ac.id/id/eprint/213995 |
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