Kristyanti, Antonia Tita and Dr. dr. Supriono, Sp.PD-KGEH, FINASIM and Dr. dr. Bogi Pratomo Wibowo, Sp.PD, K-GEH, FINASIM (2024) Perbandingan Kadar Immature Platelet Fraction pada Pasien Sirosis Hati dengan Pasien Hepatitis Kronis. Sarjana thesis, Universitas Brawijaya.
Abstract
Pendahuluan: Hepatitis merupakan peradangan hati yang umumnya disebabkan oleh Virus Hepatitis A, B, dan C. Perkembangan dari penyakit hati kronis dapat memicu sirosis yaitu pembentukan jaringan fibrosa dan nodul pada hati. Kejadian trombositopenia seringkali ditemukan pada pasien hepatitis dan sirosis. Immature Platelet Fraction (IPF) dapat menjadi parameter trombositopenia. Adapun studi terkait trombositopenia pada penyakit hati kronis dan sirosis belum sepenuhnya dipahami. Tujuan: Mengetahui perbedaan kadar IPF pada pasien sirosis hati dan pasien hepatitis kronis. Metode: Penelitian dengan desain case-control ini membandingkan kadar IPF antara kelompok kasus (sirosis) dan kontrol (hepatitis kronis). Sebanyak 68 subjek dari RSUD Dr. Saiful Anwar Malang menjadi sampel penelitian berdasarkan kriteria inklusi dan eksklusi. Adapun penelitian ini menggunakan data sekunder yaitu rekam medis pasien dari bulan Januari-Oktober 2023. Analisis data menggunakan uji Independent T-Test dengan software SPSS. Hasil dan Pembahasan: Berdasarkan uji independent sample t-test, ditemukan kadar IPF pada penderita sirosis hati lebih tinggi secara signifikan dibandingkan penderita hepatitis kronis p<0.05 (p=0.004). Adapun uji Chi-square, tidak didapati hubungan signifikan antara splenomegali dengan kadar IPF pada pasien hepatitis kronis dan sirosis hati. Kesimpulan: Terdapat perbedaan signifikan kadar IPF pada pasien sirosis hati dengan kadar IPF pada pasien sirosis hati lebih tinggi daripada pasien hepatitis kronis.
English Abstract
Introduction: Hepatitis is liver inflammation commonly caused by Hepatitis A, B, and C viruses. The progression of chronic liver disease can lead to cirrhosis, characterized by the formation of fibrous tissue and nodules in the liver. Thrombocytopenia is often found in patients with hepatitis and cirrhosis. Immature Platelet Fraction (IPF) can serve as a parameter for thrombocytopenia. However, studies related to thrombocytopenia in chronic liver disease and cirrhosis are not fully understood. Objective: To determine the difference in IPF levels between cirrhosis and chronic hepatitis patients. Methods: This case-control study compared IPF levels between the case group (cirrhosis) and the control group (chronic hepatitis). A total of 68 subjects from Dr. Saiful Anwar Hospital in Malang were selected as research samples based on inclusion and exclusion criteria. This study used secondary data, namely patients' medical records from January to October 2023. Data analysis was performed using Independent T-Test with SPSS software. Results and Discussion: Based on the independent sample t-test, it was found that IPF levels in cirrhosis patients were significantly higher than in chronic hepatitis patients (p<0.05, p=0.004). The Chisquare test did not find a significant relationship between splenomegaly and IPF levels in patients with chronic hepatitis and cirrhosis. Conclusion: There is a significant difference in IPF levels between cirrhosis patients, with IPF levels higher in cirrhosis patients compared to chronic hepatitis patients.
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | 0524060021 |
| Uncontrolled Keywords: | Immature Platelet Fraction, IPF Sirosis Hati, Hepatitis Kronis |
| Divisions: | Fakultas Kedokteran > Pendidikan Dokter |
| Depositing User: | Endang Susworini |
| Date Deposited: | 07 Feb 2024 07:59 |
| Last Modified: | 07 Feb 2024 07:59 |
| URI: | http://repository.ub.ac.id/id/eprint/213816 |
![[thumbnail of DALAM MASA EMBARGO]](http://repository.ub.ac.id/style/images/fileicons/text.png) |
Text (DALAM MASA EMBARGO)
Antonia Tita Kristyanti.pdf Restricted to Registered users only Download (2MB) |
Actions (login required)
 |
View Item |