Falyani, Silvy Amalia and dr. Suryanti Dwi Pratiwi,, Sp.P(K) and dr. Ungky Agus Setyawan,, Sp.P(K) and dr. Dini Rachma Erawati,, Sp.Rad(K) (2023) Analisis Nilai D-dimer dengan Skor Brixia pad Kematian Pasien COVID-19 Rawat Inap di RSUD dr. Saiful Anwar. Magister thesis, Universitas Brawijaya.
Abstract
Latar Belakang : Mortalitas COVID-19 (COVID-19) adalah sindrom pernafasan akut yang parah dan sangat menular yang disebabkan oleh virus SARS-CoV-2. Berbagai faktor dapat meningkatkan risiko kematian pasien, termasuk koagulopati yang ditandai dengan peningkatan kadar D-dimer. D-dimer bisa menjadi salah satu penentu keparahan COVID-19, seperti yang dinilai dari rontgen dada. Penelitian ini bertujuan untuk menganalisis keparahan radiografi toraks berdasarkan skor Brixia pada derajat koagulasi berdasarkan D-dimer pada kematian pasien COVID- 19 yang dirawat di rumah sakit. Metode : Studi retrospektif dilakukan di RS Dr. Saiful Anwar dengan desain observasional cross-sectional yang melibatkan 300 rekam medis pasien COVID- 19 yang meninggal dunia selama dirawat di rumah sakit. Data dianalisis menggunakan uji Wilcoxon, dan hasilnya juga diuji korelasi Spearman untuk mengetahui hubungan antar variabel. Hasil : Perbandingan D-dimer awal dan D-dimer masuk akhir dengan uji Wilcoxon menunjukkan bahwa median D-dimer awal 1,4 (0,24-79,27) lebih rendah daripada median D-dimer akhir 4,33 (0,63-470,6), dengan perbedaan yang signifikan (p=0,000). Perbandingan skor Brixia awal dan akhir menunjukkan bahwa rata-rata skor Brixia awal 15,0 (6,0-18,0) lebih rendah dari skor Brixia akhir 16,0 (6,0-18, 0), meskipun tidak ada perbedaan yang signifikan (p=0,165). Kesimpulan : Peningkatan skor D-dimer dan Brixia berkorelasi signifikan dengan mortalitas pada pasien COVID-19.
English Abstract
Background : Coronavirus disease 2019 (COVID-19) is a severe and highly contagious acute respiratory syndrome caused by SARS-CoV-2 virus. A variety of factors can increase a patient's risk of death, including coagulopathy characterized by increased D-dimer levels. D-dimer could be one of the determinants of COVID- 19 severity, as assessed by chest radiographs. This study aimed to analyze chest radiographic severity based on Brixia score at degree of coagulation based on Ddimer in mortality COVID-19 patients who was hospitalized. Method : The retrospective study was conducted at Dr. Saiful Anwar hospital by an observational cross-sectional design that included of 300 medical records COVID-19 patients who passed away while hospitalized. Data were analyzed using the Wilcoxon test, and the results were also tested for Spearman correlation to determine relationships between variables. Result : A comparison of initial D-dimer and final admission D-dimer by Wilcoxon test showed that the median initial D-dimer of 1.4 (0.24-79.27) was lower than the median final D-dimer of 4.33 (0.63-470.6), with significant difference (p=0.000). Comparison of initial and final Brixia scores showed that mean initial Brixia scores of 15.0 (6.0-18.0) were lower than final Brixia scores of 16.0 (6.0-18, 0), although there was no significant difference (p=0.165). Conclusion : Increased D-dimer and Brixia scores were significantly correlated with mortality in COVID-19 patients.
Item Type: | Thesis (Magister) |
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Identification Number: | 042306 |
Uncontrolled Keywords: | Mortalitas COVID-19, D-dimer, Koagulopati, Skor Brixia COVID-19 mortality, Brixia score |
Divisions: | Profesi Kedokteran > Spesialis Pulmonologi dan Kedokteran Respirasi, Fakultas Kedokteran |
Depositing User: | Unnamed user with username ihwan |
Date Deposited: | 16 Jan 2024 08:36 |
Last Modified: | 16 Jan 2024 08:36 |
URI: | http://repository.ub.ac.id/id/eprint/211139 |
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