Pramitra Permatasari, Adinda and dr. Ungky Agus Setyawan,, Sp.P(K) and dr. Sastia Rakhma,, Sp.P(K) and Prof. Drs. Arinto Yudi Ponco Wardoyo,, M.Sc.,Ph.D (2023) Analisis Volatile Organic Compound (VOC) Dari Pemeriksaan Breath Analyzer dan Serum IL-17 Terhadap Evaluasi Respon Terapi Dengan RECIST Pada Pasien Kanker Paru Di RSUD Dr. Saiful Anwar. Magister thesis, Universitas Brawijaya.
Abstract
PENDAHULUAN: Kanker paru penyebab kematian kedua dunia dikarenakan keterlambatan diagnosis. Metode non invasif Volatile Organic Compound (VOC) untuk mendiagnosis dan monitor perkembangan terapi kanker paru. Interleukin-17 (IL-17) berperan penting dalam progresifitas dan pengobatan kanker paru. Evaluasi objektif kemoterapi menggunakan Response Evaluation Criteria in Solid Tumors (RECIST 1.1). Penelitian ini bertujuan mengetahui hubungan antara VOC, IL-17 terhadap respon kemoterapi kanker paru berdasarkan RECIST di RSUD Saiful Anwar. Metode: Penelitian cohort prospective, 47 pasien kanker paru yang mendapat kemoterapi lini pertama sebelum dan setelah terapi 3 seri. Hembusan napas dikumpulkan dengan Tedlar Bags lalu dianalisa dengan μβreath untuk pemeriksaan VOC. Serum darah untuk pemeriksaan IL-17 dengan Enzyme-linked immunosorbent assay (ELISA). Data dianalisis menggunakan uji Wilcoxon, Mannwitney dan Spearman. HasiI: Terdapat perbedaan signifikan (p<0,05) Formaldehyde (CH2O), Toluene (C7H8), Acetone (C3H6O), Hexane (C6H14), Methane (CH4), RECIST lesi non target dan lesi baru sebelum dan setelah kemoterapi 3 seri tetapi tidak signifikan pada IL-17. Acetone (C3H6O) sebelum dan Methane (CH4), IL-17 setelah kemoterapi 3 seri berdasarkan RECIST Overall Respon (OR) didapatkan perbedaan signifikan (p<0,05). Analisa menunjukkan korelasi positif CH2O sebelum kemoterapi (Sensitivity 60%; Spesifisitas 66,67%; PPV 57,14%; NPV 69,23%) sedangkan Methane (CH4) (Sensitivity 60%; Spesifisitas 70,37%; PPV 60%; NPV 70,37%), IL- 17 (Sensitivity 65%; Spesifisitas 66.67%; PPV 59,09%; NPV 72%) setelah kemoterapi 3 seri berdasarkan RECIST OR tetapi korelasi negatif Acetone (C3H6O) sebelum kemoterapi (Sensitivity 65%, Spesifisitas 62.96%, PPV 56,52%; NPV 70,83%). KESIMPULAN: Formaldehyde (CH2O) dan Acetone (C3H6O) berpotensi sebagai skrining kanker paru sedangkan Methane (CH4), dan IL-17 sebagai diagnostik evaluasi respon kemoterapi yang berkorelasi dengan RECIST OR.
English Abstract
Background: Lung cancer is the second leading cause of death in the world due to delays in diagnosis. Non-invasive Volatile Organic Compound (VOC) method to diagnose and monitor the progressivity of lung cancer. Interleukin-17 (IL-17) has an important role in the progression and treatment of lung cancer. Objective evaluation of chemotherapy using Response Evaluation Criteria in Solid Tumors (RECIST 1.1). This study aims to determine the relationship between VOC, IL-17, and lung cancer chemotherapy response based on RECIST at Saiful Anwar Hospital. Methods:Prospective cohort study, 47 lung cancer patients who received first-line chemotherapy before and after 3 series of therapy. Exhaled breath was collected with Tedlar Bags and then analyzed with μβreath for VOC. IL-17 in blood serum is determined by Enzyme-linked immunosorbent assay (ELISA). Data were analyzed using the Wilcoxon, Mann-Whitney, and Spearman tests. Results:There were significant (p<0.05) Formaldehyde (CH2O), Toluene (C7H8), Acetone (C3H6O), Hexane (C6H14), Methane (CH4), RECIST non-target lesions and new lesions before and after 3 series of chemotherapy but not found in IL-17. C3H6O before and CH4, IL-17 after 3 series of chemotherapy based on RECIST Overall Response (OR) found significant. The analysis showed a positive correlation between CH2O before (Sensitivity 60%; Spesifisitas 66,67%; PPV 57,14%; NPV 69,23%) and CH4 (Sensitivity 60%; Spesifisitas 70,37%; PPV60%; NPV 70,37%), IL-17 (Sensitivity 65%; Spesifisitas 66.67%; PPV 59,09%; NPV 72%) after 3 series of chemotherapy based on RECIST OR, but a negative correlation C3H6O before chemotherapy (Sensitivity 65%; Spesifisitas 62.96%; PPV 56,52%; NPV70,83%). Conclusion: Formaldehyde (CH2O) and Acetone (C3H6O) have the potential to screen for lung cancer, while Methane (CH4), IL-17 are diagnostic evaluations of chemotherapy response that correlate with RECIST OR.
| Item Type: | Thesis (Magister) |
|---|---|
| Identification Number: | 042306 |
| Uncontrolled Keywords: | Volatile Organic Compound, Interleukin-17, RECIST 1.1 |
| Divisions: | Profesi Kedokteran > Spesialis Pulmonologi dan Kedokteran Respirasi, Fakultas Kedokteran |
| Depositing User: | Unnamed user with username ihwan |
| Date Deposited: | 09 Jan 2024 07:57 |
| Last Modified: | 09 Jan 2024 07:57 |
| URI: | http://repository.ub.ac.id/id/eprint/206688 |
![[thumbnail of DALAM MASA EMBARGO]](http://repository.ub.ac.id/style/images/fileicons/text.png) |
Text (DALAM MASA EMBARGO)
Adinda Pramitra Permatasari.pdf Restricted to Registered users only until 31 December 2025. Download (11MB) |
Actions (login required)
 |
View Item |