Wati, Putri Nabilla and apt. Efta Triastut, S.Si., M.Farm.Klin., Ph.D. and apt. Oktavia Eka Puspita, S.Farm., M.Sc. (2023) Systematic Literature Review: Pengembangan Terapi Berbasis Liposom Untuk Hewan Model Infark Miokard. Sarjana thesis, Universitas Brawijaya.
Abstract
Sistem penghantaran liposom banyak digunakan karena memiliki peran yang penting dalam peningkatan efek terapi dan secara efektif dapat menjadi pengembangan sistem penghantaran obat karena memiliki karakteristik yang menguntungkan. Penghantaran liposom dapat digunakan pada pengobatan yang dapat memberikan strategi terapeutik penting untuk mengurangi kerusakan infark miokard dan dengan meningkatkan fungsi jantung maupun struktur jantung. Pada penelitian ini bertujuan untuk mengetahui pengembangan terapi berbasis liposom untuk hewan model infark miokard. Metode yang digunakan yaitu Systematic Literature Review. Pencarian literatur secara komprehensif dilakukan menggunakan software Harzing’s Publish or Perish dari beberapa database yaitu Scopus, Google Scholar, dan PubMed dengan kata kunci “liposome” OR “drug delivery system” AND “myocardial infarction” AND “animal” AND “cardiac remodeling”. Alur penyeleksian artikel menggunakan protokol Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA). Hasil seleksi data artikel terdapat 13 artikel yang sesuai dengan kriteria inklusi dan ekslusi yang ditetapkan, yaitu artikel yang membahas terapi berbasis liposom pada hewan model infark miokard. Parameter yang dinilai yaitu fungsi jantung berupa ejection fraction dan fractional shortening dan parameter struktur jantung yaitu ukuran infark, hipertrofi, ketebalan dinding posterior jantung dan intraventrikular. Berdasarkan parameter tersebut, pada terapi berbasis liposom beberapa artikel menunjukkan perbaikan terhadap kondisi infark miokard hewan model, sehingga terapi berbasis liposom dapat digunakan pada pengobatan infark miokard.
English Abstract
Liposome delivery systems are widely used because they have an important role in enhancing therapeutic effects and can effectively be the development of drug delivery systems because they have beneficial characteristics. Liposome delivery can be used in medicine which can provide important therapeutic strategies to reduce myocardial infarction damage and by improving cardiac function and cardiac structure. This study aims to determine the development of liposome-based therapy for animal models of myocardial infarction. The method used is Systematic Literature Review. A comprehensive literature search was performed using Harzing's Publish or Perish software from several databases, namely Scopus, Google Scholar, and PubMed with the keywords "liposome" OR "drug delivery system" AND "myocardial infarction" AND "animal" AND "cardiac remodeling". The flow of selecting articles uses the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) protocol. As a result of the selection of article data, 13 articles met the established inclusion and exclusion criteria, namely articles that discussed liposome-based therapy in animal models of myocardial infarction. The parameters assessed were cardiac function in the form of ejection fraction and fractional shortening and structural parameters of the heart, specifically infarct size, hypertrophy, the thickness of the posterior wall of the heart, and intraventricular. Based on these parameters, several articles on liposome-based therapy have shown improvement in animal model myocardial infarction, so that liposome-based therapy can be used in the treatment of myocardial infarction.
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | 0523060150 |
| Uncontrolled Keywords: | Infark miokard, liposom, fungsi jantung, struktur jantung |
| Subjects: | 600 Technology (Applied sciences) > 615 Pharmacology and therapeutics > 615.1 Drugs (materia medica) |
| Divisions: | Fakultas Kedokteran > Farmasi |
| Depositing User: | Endang Susworini |
| Date Deposited: | 13 Dec 2023 07:13 |
| Last Modified: | 13 Dec 2023 07:13 |
| URI: | http://repository.ub.ac.id/id/eprint/205145 |
![[thumbnail of DALAM MASA MEMBARGO]](http://repository.ub.ac.id/style/images/fileicons/text.png) |
Text (DALAM MASA MEMBARGO)
Putri Nabilla Wati.pdf Restricted to Registered users only until 31 December 2025. Download (7MB) |
Actions (login required)
 |
View Item |