Amalia, Muna and dr. Ovi Sofia, Sp.M(K) and Prof. Dr. dr. Loeki Enggar Fitri, M.Kes, Sp.ParK (2023) Hubungan antara Jumlah Sel Treg dengan Ukuran Lesi Retina dan Derajat Inflamasi Vitreus pada Toksoplasmosis Okuler. Magister thesis, Universitas Brawijaya.
Abstract
Metode: Penelitian ini menggunakan desain observasional analitik dengan pendekatan cross sectional, dilakukan selama 8 bulan, melibatkan 11 orang pasien TO dan 10 orang individu seropositif tanpa lesi okuler di RSSA Malang. Seluruh subjek penelitian dilakukan pemeriksaan segmen anterior menggunakan slitlamp biomicroscope dan pemeriksaan segmen posterior dengan binocular indirect ophthalmoscopy dan foto fundus. Pengukuran luas lesi retina menggunakan perangkat lunak Digimizer 4.2.2.0. Dilakukan isolasi PBMC (Peripheral Blood Mononuclear Cells) untuk pengukuran jumlah sel Treg dengan flow cytometri. Data dianalisis menggunakan SPSS. Hasil: Rata-rata jumlah sel Treg pada kelompok TO (47.16±15.66%) lebih rendah (p=0.029) dibandingkan kelompok seropositif tanpa lesi okuler (62.86±17.08%). Jumlah sel Treg berhubungan signifikan dengan ukuran lesi retina (p=0.043), dengan koefisien korelasi -0.648 yang menunjukkan hubungan yang kuat dan berbanding terbalik. Jumlah sel Treg tidak berhubungan signifikan dengan derajat inflamasi vitreus (p=0.083). Kesimpulan : Jumlah sel Treg pada pasien TO lebih rendah dibandingkan dengan individu seropositif tanpa lesi okuler. Jumlah sel Treg berbanding terbalik dengan ukuran lesi retina. Tidak terdapat hubungan antara jumlah sel Treg dengan derajat inflamasi vitreus.
English Abstract
Objectives: To determine the difference in the number of Treg cells between Ocular Toxoplasmosis (OT) patients and seropositive individuals without ocular lesion, and to analyze the relationship between the number of Treg cells, retinal lesion size, and degree of vitreous inflammation in OT patients. Methods: This was an analytic observational study with a cross-sectional design. The study was conducted for 8 months, involving 11 OT patients and 10 seropositive individuals without ocular lesion in Dr. Saiful Anwar General Hospital Malang. All subjects underwent anterior segment examination using a slitlamp biomicroscope and posterior segment examination using binocular indirect ophthalmoscopy and fundus photograph. The retinal lesion size was measured using Digimizer 4.2.2.0 software. The number of Treg cells was measured by flow cytometry with PBMC (Peripheral Blood Mononuclear Cells) as a sample. Data were analyzed using SPSS. Results: The average of the number of Treg cells in the OT group (47.16±15.66%) was lower (p=0.029) than the seropositive group without ocular lesion (62.86±17.08%). The number of Treg cells was significantly related to the retinal lesion size (p=0.043), with correlation coefficient -0.648 indicates a strong and reverse relative relationship. The number of Treg cells was not significantly related to the degree of vitreous inflammation (p=0.083). Conclusion: The number of Treg cells in OT patients is lower than the seropositive individuals without ocular lesion. There is an inverse relationship between the number of Treg cells and the retinal lesion size. There is no relationship between the number of Treg cells and the degree of vitreous inflammation.
| Item Type: | Thesis (Magister) |
|---|---|
| Identification Number: | 423060078 |
| Uncontrolled Keywords: | sel Treg, toksoplasmosis okuler, ukuran lesi retina, derajat inflamasi vitreus, seropositif |
| Subjects: | 600 Technology (Applied sciences) > 617 Surgery, regional medicine, dentistry, ophthalmology, otology, audiology > 617.7 Ophthalmology |
| Divisions: | Profesi Kedokteran > Spesialis Ilmu Kesehatan Mata, Fakultas Kedokteran |
| Depositing User: | Endang Susworini |
| Date Deposited: | 08 Dec 2023 08:56 |
| Last Modified: | 08 Dec 2023 08:56 |
| URI: | http://repository.ub.ac.id/id/eprint/205014 |
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