Thomassawa, Herryanto and dr. Ovi Sofia, Sp.M (K) and Prof. Dr. dr. Loeki Enggar Fitri, M.Kes., SpParK (2023) Hubungan antara Kadar Interleukin 27 (IL-27) Serum dengan Ukuran Lesi dan Derajat Inflamasi Vitreus pada Toksoplasmosis Okuler. Magister thesis, Universitas Brawijaya.
Abstract
Tujuan: Menilai perbedaan kadar IL-27 serum pada pasien toksoplasmosis okuler (TO) dibandingkan individu seropositif tanpa lesi okuler serta hubungannya dengan ukuran lesi retina dan derajat inflamasi vitreus. Metode: Penelitian ini merupakan studi analitik observasional dengan pendekatan potong lintang. Sampel penelitian merupakan pasien poliklinik mata RSUD Dr. Saiful Anwar Malang yang dibagi menjadi 2 kelompok yaitu kelompok TO dan kelompok seropositif tanpa lesi okuler. Pada setiap kelompok dilakukan pemeriksaan kadar IL-27 serum dengan metode sandwich enzyme linked immunosorbent assay (ELISA) kemudian dilakukan uji statistik untuk menilai perbedaan kadar IL-27 serum pada kedua kelompok. Pada kelompok toksoplasmosis okuler dilakukan pengukuran luas lesi retina dan serta derajat inflamasi vitreus kemudian dilakukan analisa statistik dengan SPSS 26.0 untuk melihat hubungan keduanya dengan kadar IL-27 serum. Hasil: Total sampel pada penelitian ini sebanyak 21 orang yaitu 11 pasien dengan toksoplasmosis okuler dan 10 individu seropositif (tanpa lesi okuler). Uji beda kadar IL-27 serum antara kelompok TO dan kelompok seropositif tanpa lesi okuler menunjukkan tidak ada perbedaan yang signifikan (p=0,360). Uji korelasi kadar IL-27 serum dengan ukuran lesi retina juga menunjukkan tidak terdapat hubungan yang signifikan (p=0,556). Uji korelasi antara kadar IL-27 serum dengan derajat inflamasi vitreus tidak terdapat hubungan yang signifkan (p=0,215). Kesimpulan: Tidak terdapat perbedaan kadar IL-27 serum antara pasien TO dan individu seropositif tanpa lesi okuler dan kadar IL-27 serum pada kelompok TO tidak berhubungan dengan luas lesi retina maupun derajat inflamasi vitreus.
English Abstract
Objective: To investigate the differences in serum IL-27 levels between people with ocular toxoplasmosis (OT) and seropositive individuals without ocular lesions, as well as the correlations between serum IL-27 levels and the size of retinal lesions, and the degree of vitreous inflammation. Method: An observational cross-sectional design is used in this study. The study's sample consisted of two groups of patients from RSUD Dr. Saiful Anwar Malang's Eye Clinic: those who had ocular toxoplasmosis and those who were seropositive without ocular lesions. Using the sandwich ELISA technique, the serum IL-27 levels in each group were assessed, and any differences between the two groups' serum IL-27 levels were statistically examined. The size of the retinal lesion and the degree of vitreous inflammation were assessed in patients with ocular toxoplasmosis, and statistical analysis was performed to determine the relationship between these parameters and serum IL-27 levels. Results: The total sample size for this study was 21 people, consisting of 10 seropositive individuals and 11 patients with ocular toxoplasmosis. There was no significant difference in serum IL-27 levels between the OT group and the seropositive group (p=0.360). There was no significant correlation between serum IL-27 levels and retinal lesion size (p=0.556). Additionally, there was no significant correlation between serum IL-27 levels and the severity of ocular inflammation (p=0.215). Conclusion: There was no difference in serum IL-27 levels between OT patients and seropositive individuals, and serum IL-27 levels in the OT group were not related to the size of retinal lesions or the degree of vitreous inflammation.
| Item Type: | Thesis (Magister) |
|---|---|
| Identification Number: | 0423060058 |
| Uncontrolled Keywords: | Toksoplasmosis okuler, Interleukin 27, Lesi Retinokoroidal, Inflamasi Vitreus, Individu seropositif tanpa lesi okuler. |
| Subjects: | 600 Technology (Applied sciences) > 617 Surgery, regional medicine, dentistry, ophthalmology, otology, audiology > 617.7 Ophthalmology |
| Divisions: | Profesi Kedokteran > Spesialis Ilmu Kesehatan Mata, Fakultas Kedokteran |
| Depositing User: | Endang Susworini |
| Date Deposited: | 05 Dec 2023 06:19 |
| Last Modified: | 05 Dec 2023 06:19 |
| URI: | http://repository.ub.ac.id/id/eprint/204677 |
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