Sianturi, Duma Aulia and Prof. Dr. dr. Handono Kalim, Sp.PD, K- R and dr. Perdana Aditya Rahman, Sp.PD, K-R (2023) Korelasi antara Persentase Sel Treg dan Sel B dengan Aktivitas Penyakit pada Pasien Artritis Reumatoid di RSUD Dr. Saiful Anwar Malang. Magister thesis, Universitas Brawijaya.
Abstract
Pendahuluan: Artritis reumatoid (AR) adalah penyakit autoimun kompleks yang melibatkan imunitas seluler dan humoral, yang mengeluarkan berbagai sitokin, kemokin, mediator inflamasi, dengan berbagai jalur patogenik dan mekanisme regulasi. Sel Treg berperan penting dalam menekan respons imun dan mempertahankan hemostasis respons imun. Sel B berperan dalam patogenesis AR melalui produksi autoantibodi, presentasi antigen, dan aktivasi osteoklas. Sel Treg diketahui dapat mempengaruhi sel B dengan menekan respons dan produksi autoantibodi sel B. Disregulasi sel Treg menyebabkan peningkatan respons inflamasi pada AR. Penelitian ini bertujuan untuk mengetahui korelasi antara jumlah sel Treg CD4+CD25+FOXP3+, sel B CD19+CD20+, dan rasio sel Treg/sel B dengan aktivitas penyakit pada pasien artritis reumatoid. Metode: Penelitian ini menggunakan desain studi potong lintang pada 41 subjek pasien yang terdiagnosis artritis reumatoid berdasarkan kriteria ACR/EULAR 2010. Persentase sel Treg CD4+CD25+FOXP3+ dan sel B CD19+CD20+ diukur dari sampel darah tepi dengan menggunakan flowsitometri. Aktivitas penyakit dinilai dengan menggunakan skor DAS28-LED. Hasil: Persentase sel Treg CD4+CD25+FOXP3+, sel B CD19+CD20+, dan rasio sel Treg/sel B tidak berkorelasi dengan aktivitas penyakit (skor DAS28-LED) [(r=-0,198, p=0,214); (r=0,082, p=0,610); (r=-0,209, p=0,191)]. Kesimpulan: Penelitian kami menunjukkan bahwa tidak terdapat korelasi antara sel Treg, sel B, dan rasio sel Treg/sel B dengan aktivitas penyakit pada pasien artritis reumatoid.
English Abstract
Introduction: Rheumatoid arthritis is a complex autoimmune disease involving cellular and humoral immunity, which secretes various cytokines, chemokines, inflammatory mediators, with various pathogenic pathways and regulatory mechanisms. Treg cells play an important role in suppressing the immune response and maintaining immune response homeostasis. B cells play a role in AR pathogenesis through autoantibody production, antigen presentation, and osteoclast activation. Treg cells are known to influence B cells by suppressing the response and production of B cell autoantibodies. Treg cell dysregulation leads to increased inflammatory response in AR. This study aimed to observe the correlation between the number of CD4+CD25+FOXP3+ Treg cells, CD19+CD20+ B cells, and the Treg/B cell ratio with disease activity in rheumatoid arthritis patients. Methods: This was a study with a cross-sectional study design on 41 subjects diagnosed as rheumatoid arthritis based on ACR/EULAR 2010 criteria. The percentages of CD4+CD25+FOXP3+ Treg cells and CD19+CD20+ B cells were measured from peripheral blood samples using flow cytometry. Disease activity was assessed using the DAS28-ESR score. Results: The percentages of CD4+CD25+FOXP3+ Treg cells, CD19+CD20+ B cells, and the Treg/B cell ratio did not correlate with disease acitivity (DAS28-ESR score) [(r=-0.198, p=0.214); (r=0.082, p=0.610); (r=-0.209, p=0.191)]. Conclusions: There was no correlation between Treg cells, B cells and Treg/B cell ratio with disease activity in rheumatoid arthritis patients.
| Item Type: | Thesis (Magister) |
|---|---|
| Identification Number: | 0423060042 |
| Uncontrolled Keywords: | Artritis Reumatoid, sel Treg, sel B, DAS28-LED, aktivitas penyakit |
| Subjects: | 600 Technology (Applied sciences) > 616 Diseases |
| Divisions: | Profesi Kedokteran > Spesialis Ilmu Penyakit Dalam, Fakultas Kedokteran |
| Depositing User: | Endang Susworini |
| Date Deposited: | 27 Nov 2023 01:13 |
| Last Modified: | 27 Nov 2023 01:13 |
| URI: | http://repository.ub.ac.id/id/eprint/204564 |
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