Rosalia, Dian and Dr. dr Debby Shintiya D,, Sp M (K and dr. Wino Vrieda Vierlia, Sp M (K) (2023) Efek Pemberian Intravena Methylprednisolone Pulse Therapy (IVMP) Terhadap Derajat Keparahan Thyroid Eye Disease (TED),. Magister thesis, Universitas Brawijaya.
Abstract
Tujuan: Mengetahui efek pemberian Intravena Methylprednisolone Pulse Therapy (IVMP) terhadap derajat keparahan Thyroid Eye Disease (TED), retraksi kelopak mata dan eksoftalmos Metode: Penelitian dengan desain deskriptif analitik dengan pendekatan retrospektif. Dilakukan pengambilan data dari rekam medis pasien TED di klinik mata Divisi Rekonstruksi, Okuloplasti dan Onkologi RSUD Dr.Saiful Anwar Malang bulan Januari 2019 sampai Desember 2022. Data yang diambil adalah data demografi, retraksi kelopak mata, eksoftalmos dan derajat keparahan sebelum pemberian IVMP dan setelah pemberian IVMP. Retraksi kelopak mata dan derajat keparahan TED dianalisis menggunakan uji Chi Square sedangkan eksoftalmos dilakukan uji Wilcoxon. Hasil: Terdapat perbedaan retraksi pre dan post pemberian IVMP yang signifikan dengan p value sebesar 0,020< (=0,05), terdapat perbedaan eksoftalmos pre dan post pemberian IVMP yang signifikan dengan p value sebesar. 0,009< (=0,05). Tidak terdapat perbedaan derajat keparahan TED pre dan post pemberian IVMP yang signifikan dengan p value sebesar 0,352> (=0,05). Kesimpulan: Terdapat penurunan retraksi kelopak mata yang signifikan antara sebelum dan sesudah pemberian Metilprednisolon pulse terapi pada pasien TED. Terdapat penurunan eksoftalmos yang signifikan antara sebelum dan sesudah pemberian Metilprednisolon pulse terapi pada pasien TED. Tidak terdapat perbedaan derajat keparahan yang signifikan antara sebelum dan sesudah pemberian Metilprednisolon pulse terapi pada pasien TED.
English Abstract
Objective: To determine the effect of Intravenous Methylprednisolone Pulse Therapy (IVMP) on the severity of Thyroid Eye Disease (TED), eyelid retraction and exophthalmos. Methods: A descriptive analytical study with retrospective approach. The data collected from TED patients' medical records, from Reconstruction, Oculoplasty and Oncology Division Eye Outpatient clinic of Dr.Saiful Anwar Malang general hospital from January 2019 to December 2022. The data taken were demographic data, eyelid retraction, exophthalmos and degree of severity before IVMP administration and after IVMP administration. Eyelid retraction and degree of severity of TED were analyzed using Chi Square test, eksofthalmos was analyze using Wilcoxon test. Result: there is a significant difference in pre and post ivmp retraction with a p value of 0.020<, there is a significant difference in pre and post exophthalmos with a P value of IVMP. 0,009< (=0,05). There was no significant difference in the severity of TED pre and post ivmp administration with a p value of 0.352> (=0.05). Conclusion: there was a significant decrease in eyelid retraction between before and after administration of IVMP in TED patients. There was a significant reduction in exophthalmos between before and after administration of IVMP in TED patients. There was no significant difference in severity between before and after IVMP in TED patients.
| Item Type: | Thesis (Magister) |
|---|---|
| Identification Number: | 0423060041 |
| Uncontrolled Keywords: | Thyroid Eye Disease, Graves Ophthalmopathy, Pulse Therapy, Methylprednisolone |
| Subjects: | 600 Technology (Applied sciences) > 617 Surgery, regional medicine, dentistry, ophthalmology, otology, audiology > 617.7 Ophthalmology |
| Divisions: | Profesi Kedokteran > Spesialis Ilmu Kesehatan Mata, Fakultas Kedokteran |
| Depositing User: | Endang Susworini |
| Date Deposited: | 15 Nov 2023 06:10 |
| Last Modified: | 15 Nov 2023 06:10 |
| URI: | http://repository.ub.ac.id/id/eprint/204556 |
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