Devy, Fahrisa Riskia and apt. Uswatun Khasanah, M.Farm and apt. Thia Amalia, M.Si. (2023) Optimasi Formula Tablet Ekstrak Batang Songga (Strychnos lucida R. Br.) dengan Modifikasi Bahan Pengisi atau Adsorbent. Sarjana thesis, Universitas Brawijaya.
Abstract
Songga (Strychnos lucida R.Br.) secara empiris digunakan untuk mengobati malaria dengan cara mengambil ekstrak hasil rebusan. Akan tetapi, hal tersebut tidak terstandarisasi dan menyebabkan ketidaktepatan dosis, sehingga dibuat sediaan tablet agar mudah dikonsumsi dengan dosis yang tepat. Peneltian ini bertujuan untuk mengetahui formula tablet yang optimum menggunakan perbedaan bahan pengisi atau adsorbent yaitu aerosil dan avicel. Pengujian tablet pada masing-masing formula dilakukan sesuai dengan Peraturan BPOM Nomor 32 Tahun 2019 tentang Persyaratan Keamanan dan Mutu Obat Tradisional serta Farmakope Indonesia. Sediaan tablet diuji organoleptik, keseragaman bobot, keseragaman ukuran, kekerasan, waktu hancur, serta kerapuhan. Tablet dengan bahan adsorbent aerosil memiliki keseragaman bobot dan keseragaman ukuran yang memenuhi spesifikasi dengan kekerasan 4,61 kg/m2, waktu hancur 20 menit, dan kerapuhan 0,05%. Kesimpulannya adalah bahan adsorbent aerosil mampu menghasilkan Tablet Ekstrak Batang Songga dengan karakteristik yang memenuhi persyaratan mutu obat tradisional.
English Abstract
Songga (Strychnos lucida R.Br.) empirically used to cure malaria by taking the extract from the decoction. However, this preparation is unstandardized and led to dosage inaccuracies, so tablets were made to make them easy to consume at the right dosage. This research is aimed to determine the optimum tablet formulation using different excipient filler or adsorbent namely aerosil and avicel. Quality control of each formulation was guided by BPOM Regulation Number 32 of 2019 concerning Safety and Quality Requirements for Indonesian Traditional Medicines and Indonesian Pharmacopoeia. Tablet preparations were tested for variations in weight, size uniformity, hardness, disintegration time, and friability. Tablets that contain aerosil as an adsorbent exhibited uniform weight and size that meet the specifications. The hardness is 4.61 kg/m2, the disintegration time is 20 minutes, and the friability value is 0.05%. We conclude that the formula with aerosil as an adsorbent capable of producing Tablets Extract Songga Wood with characteristics that fulfill traditional medicine’s quality requirements.
Other obstract
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| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | '0523060004 |
| Uncontrolled Keywords: | Strychnos lucida, malaria, obat tradisional, tablet,-Strychnos lucida, malaria, traditional medicine, tablet |
| Subjects: | 600 Technology (Applied sciences) > 615 Pharmacology and therapeutics > 615.1 Drugs (materia medica) |
| Divisions: | Fakultas Kedokteran > Farmasi |
| Depositing User: | Endang Susworini |
| Date Deposited: | 12 Jul 2023 07:07 |
| Last Modified: | 12 Jul 2023 07:07 |
| URI: | http://repository.ub.ac.id/id/eprint/201789 |
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Text (DALAM MASA EMBARGO)
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