Fariha, Safira and Sp.Perio., Drg. Diah, (2022) Uji Efektivitas Caffeic acid phenethyl ester dari Propolis sebagai Inhibitor Peptidoglycan Glycosyl Transferase untuk Peningkatan Oral Hygiene: Berbasis In Silico. Sarjana thesis, Universitas Brawijaya.
Abstract
Periodontitis merupakan salah satu penyakit gigi dan mulut yang prevalensinya masih tinggi di Indonesia. Penyakit rongga mulut ini disebabkan oleh infeksi campuran bakteri yang mengakibatkan kerusakan jaringan pendukung gigi. Tujuan: Mengetahui efektivitas caffeic acid phenethyl ester (CAPE) dari propolis sebagai inhibitor peptidoglycan glycosyl transferase (PGT) untuk peningkatan oral hygiene: berbasis in silico. Metode: Molecular docking dengan menginteraksikan senyawa CAPE dan chlorhexidine dengan protein peptidoglycan glycosyl transferase. Hasil dan Pembahasan: Interaksi senyawa CAPE dengan protein PGT menunjukkan energi ikatan lebih tinggi dibandingkan energi ikatan dari protein PGT terhadap chlorhexidine sebagai kontrol. Melalui hasil uji prediksi toksisitas, senyawa CAPE mendapatkan hasil skor yang rendah. Skor docking yang rendah akan semakin memperkuat interaksi antara senyawa dan protein, sehingga berpotensi sebagai antibakteri yang hampir sama dengan chlorhexidine. Kesimpulan: Senyawa caffeic acid phenethyl ester (CAPE) dibuktikan secara in silico memiliki potensi sebagai agen antibakteri dengan menghambat proses transferase protein peptidoglycan glycosyl transferase (PGT).
English Abstract
Periodontitis is a dental and oral disease with a high prevalence in Indonesia. This oral cavity disease is caused by a mixed bacterial infection that results in damage to the supporting tissues of the teeth. Objective: To determine the effectiveness of caffeic acid phenethyl ester (CAPE) from propolis as a peptidoglycan glycosyl transferase (PGT) inhibitor to improve oral hygiene: based on in silico. Methods: Molecular docking by interacting CAPE and chlorhexidine compounds with peptidoglycan glycosyl transferase proteins. Results and Discussion: The interaction of CAPE compounds with PGT proteins showed a higher binding energy than the binding energy of PGT proteins to chlorhexidine as a control. Through the results of the toxicity prediction test, the CAPE compound got a low score. A low docking score will further strengthen the interaction between the compound and the protein, giving it the same antibacterial potential as chlorhexidine. Conclusion: Caffeic acid phenethyl ester (CAPE) has been proven in silico to have potential as an antibacterial agent by inhibiting the protein transferase process of peptidoglycan glycosyl transferase (PGT).
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | 0522140033 |
| Uncontrolled Keywords: | In Silico, Propolis, Chlorhexidine, Caffeic Acid Phenethyl Ester, Peptidoglycan Glycosyl Transferase., In Silico, Propolis, Chlorhexidine, Caffeic Acid Phenethyl Ester, Peptidoglycan Glycosyl Transferase. |
| Subjects: | 600 Technology (Applied sciences) > 617 Surgery, regional medicine, dentistry, ophthalmology, otology, audiology > 617.6 Dentistry |
| Divisions: | Fakultas Kedokteran Gigi > Kedokteran Gigi |
| Depositing User: | Sugeng Moelyono |
| Date Deposited: | 15 May 2023 02:55 |
| Last Modified: | 15 May 2023 02:55 |
| URI: | http://repository.ub.ac.id/id/eprint/199529 |
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